99mTc-HMPAO as a tracer of cerebral blood flow in newborn infants

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 4, 1997, Pages 448-454

  Børch, Klaus ^a   Greisen, Gorm ^a  

^a Rigshospitalet   (Denmark)

Author keywords

HMPAO; Infants; Kinetics; Regional cerebral blood flow; SPECT

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; DIAGNOSTIC AGENT; OXIME; TECHNETIUM COMPLEX;

ARTICLE; BLADDER WALL; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; CLINICAL ARTICLE; FEMALE; HUMAN; IMAGE RECONSTRUCTION; INFANT; ISOTOPE LABELING; MALE; PREMATURITY; PRIORITY JOURNAL; RADIATION DOSE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; URINARY EXCRETION; BIOLOGICAL MODEL; BRAIN; BRAIN CIRCULATION; METABOLISM; NEWBORN; PHYSIOLOGY; URINE;

BRAIN; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; INFANT, NEWBORN; MALE; MODELS, CARDIOVASCULAR; ORGANOTECHNETIUM COMPOUNDS; OXIMES; TECHNETIUM TC 99M EXAMETAZIME;

EID: 0030887702     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199704000-00010     Document Type: Article

References (21)

1. 99mTc-HMPAO): basic kinetic studies of a tracer of cerebral blood flow. Cerebrovasc Brain Metab Rev 1:288-318
2. Andersen AR, Friberg H, Schmidt JF, Hasselbalch SG (1988a) Quantitative measurements of cerebral blood flow using SPECT and Tc99m-D,L-HMPAO compared to xenon-133. J Cereb Blood Flow Metab 8:S69-S81
3. 99mTc]-d,l-MH-PAO Across the blood-brain barrier. J Cereb Blood Flow Metab 8:S44-S51
4. 99mTc]-d,l-HM-PAO by rapid octanol extraction. J Cereb Blood Flow Metab 8:S32-S30
5. Celsis P, Goldman T, Henriksen L, Lassen NA (1981) A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations. J Comp Assist Tomogr 5:641-645
6. Fockele DS, Baumann RJ, Shih W, Ryo U (1989) Tc-99m HMPAO SPECT of the brain in the neonate. Clin Nucl Med 15:175-177
7. Greisen G (1986) Cerebral blood flow in preterm infants during the first week of life. Acta Paediatr Scand 75:43-51
8. 133Xe clearance in preterm neonates with respiratory distress. Internal validation of CBF as a measure of global cerebral blood flow. Scand J Clin Lab Invest 48:673-678
9. Greisen G, Frederiksen PS, Mali J, Friis-Hansen B (1984) Analysis of cranial 133-xenon clearance in the newborn infant by the two-compartment model. Scand J Clin Lab Invest 44:239-250
10. Gruenwald P, Minh HN (1960) Evaluation of body and organ weights in perinatal pathology. 1. Normal standards derived from autopsies. Am J Clin Pathol 34:247-253
11. Holm S (1988) Dynamic SPECT of the Human Brain for Measurement of Regional Cerebral Blood Flow (Dissertation), Physics Laboratory, University of Copenhagen, Denmark
12. Kanno I, Lassen NA (1979) Two methods for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations. J Comp Assist Tomogr 3:71-76
13. Kanno I, Uemura K, Miura S, Miura Y (1981) Headtome: a hybrid emission tomograph for single photon and positron emission imaging of the brain. J Comp Assist Tomogr 5:216-226
14. Larsson SA (1980) Gamma camera emission tomography. Acta Radiol Suppl 363:54
15. 99mTc]-d,l-HM-PAO in the human brain after intracarotid bolus injection: a kinetic analysis. J Cereb Blood Flow Metab 8:S13-S22
16. 99mTc]-hexamethyl-propylene amine oxime in the human brain. J Cereb Blood Flow Metab 8:S61-S68
17. Modi N (1988) Development of renal function. Br Med Bull 44:925-956
18. Neirinx RD, Burke JF, Harrison RC, Forster AM, Andersen AR, Lassen NA (1988) The retention mechanism of technetium-99m-HM-PAO: intracellular reaction with glutathione. J Cereb Blood Flow Metab 8:S4-S12
19. Sharp PF, Smith FW, Gemell HG, et al. (1986) Technetium-88m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies. J Nucl Med 27:171-7
20. m-HMPAO and SPECT: choice of reference region. Nucl Med Comm 13:811-816
21. Vestergren E, Jacobsson L, Mattson S, et al. (1992) Biokinetics and dosimetry of Tc-99m HM-PAO in children. In: Proceedings of Fifth International Radiopharmaceutical Symposium (Watson EE, Schlafkestelson AT eds) US Dept Commerce Natl Tech Information Service, Washington DC, p 443