Modulation of apolipoprotein gene expression in fatty liver of obese rats: Enhanced APOA-IV, but no APOB expression by a high sucrose diet

International Journal of Obesity

Volumn 21, Issue 3, 1997, Pages 231-238

  Inui, Y ^a   Keno, Y ^a   Fukuda, K ^a   Igura, T ^a   Makamura, T ^a   Tokunaga, K ^a   Kawata, S ^a   Matsuzawa, Y ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Apolipoprotein A IV; Apolipoprotein B; Fatty liver; Obesity; Sucrose

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; APOLIPOPROTEIN A4; APOLIPOPROTEIN B; LIVER ENZYME; MESSENGER RNA; SUCROSE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; FATTY LIVER; FEMALE; GENE EXPRESSION; HYPERLIPIDEMIA; HYPOTHALAMUS LESION; INSULIN BLOOD LEVEL; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ZONA INCERTA;

EID: 0030887338     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800392     Document Type: Article

References (30)

1. Gibbons GF. Assembly and secretion of hepatic very-low-density lipoprotein. Biochem J 1990; 268: 1-13.
2. Vance JE, Vance DE. Lipoprotein assembly and secretion by hepatocytes. Annu Rev Nutr 1990; 10: 337-356.
3. Herbert PN, Assman G, Gotto AM Jr, Fredrickson DS. Familial lipoprotein deficiency: abetalipoprotenemia; hypotalipoprotenemia and Tangier's disease. Stanbury JB, Wyngarden JB, Fredrickson DS, Goldstein JL & Brown MS (eds). In: The Metabolic Basis of Inherited Disease. McGraw-Hill, Inc: New York, 1983, pp 605-607.
4. Tokunaga K, Fukushima M, Kemnitz JW, Bray GA. Comparison of ventromedial and paraventricular lesions in rats that become obese. Am J Physiol 1986; 251: R1221-R1227.
5. Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 1979; 59: 719-809.
6. King BM, Phelps GR, Frohman LA. Hypothalamic obesity in female rats in absence of vagally mediated hyperinsulinemia. Am J Physiol 1981; 239: E437-E441.
7. Inui Y, Kawata S, Matsuzawa Y, Tokunaga K, Tamura S, Fukuda K, Maeda Y, Tarui S. Selective increase in Cytochrome p450 content in hepatic microsomes from rats with ventromedial hypothalamic lesions. Int J Obes 1991; 15: 221-225.
8. Inui Y, Kawata S, Matsuzawa Y, Tokunaga K, Fujioka S, Tamura S, Kobatake T, Tarui S. Increased level of apolipoprotein B mRNA in the liver of ventromedial hypothalamus lesioned obese rats. Biochem Biophys Res Commun 1989; 163: 1107-1112.
9. Inui Y, Nishikawa M, Minami Y, Kawata S, Nozaki S, Fujioka S, Yamada K, Tokunaga K, Matsuzawa Y, Kono N, Tarui S. Morphological study of lipoprotein particles in the livers of ventromedial hypothalamus lesioned rats. Int J Obes 1987; 11: 527-536.
10. Baum CL, Teng B, Davidson NO. Apolipoprotein B messenger RNA editing in rat liver. Modulation by fasting and refeeding a high carbohydrate diet. J Biol Chem 1990; 265: 19263-19270.
11. Elovson J, Huang O, Backer N, Kannan R. Apolipoprotein B is structurally and metabolically heterogenous in the rat. Proc Natl Acad Sci USA 1981; 78: 157-161.
12. Davis RA, Engelhorn SC, Pangburn SH, Weinstein DB, Steinberg D. Very low density lipoprotein synthesis and secretion by cultured rat hepatocytes. J Biol Chem 1979; 254: 2010-2016.
13. Yao Z, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 1988; 263: 2998-3004.
14. Apfelbaum TF, Davidson NO, Glickman RM. Apolipoprotein A-IV synthesis in rat intestine: regulation by dietary triglycerides. Am J Physiol 1987; 252: G662-G666.
15. Black DD, Rohwer-Nutter PL, Davidson NO. Intestinal apolipoprotein gene expression in the piglet. J Lipid Res 1990; 31: 497-505.
16. Lagrost L, Gambert P, Meunier S, Morgado P, Desgres J, d'Athis P, Lallemant C. Correlation between apolipoprotein A-IV and triglycerides concentrations in human sera. J Lipid Res 1989; 30: 701-710.
17. Inui Y, Giannoni F, Funahashi T, Davidson NO. PEPR and complementation factor(s) to modulate rat apolipoprotein B mRNA editing in response to alterations in cellular cholesterol flux. J Lipid Res 1994; 35: 1477-1489.
18. Inui Y, Hausman AML, Nanthakumar N, Henning SJ, Davidson NO. Apolipoprotein B messenger RNA editing in rat liver: Developmental and hormonal modulation is divergent from apolipoprotein A-IV gene expression despite increased hepatic lipogenesis. J Lipid Res 1992; 33: 1843-1856.
19. Eaton RP, Kipnis DM. Effects of high-carbohydrate on lipid and carbohydrate in the rat. Am J Physiol 1969; 217: 1160-1168.
20. Schonfeld G. Changes in the composition of very low density lipoprotein during carbohydrate in man. J Lab Clin Med 1970; 75: 206-211.
21. Ruderman NB, Jones AL, Krauss RM, Shafrir E. A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia. J Clin Invest 1971; 50: 1355-1368.
22. Witztum J, Schonfeld G. Carbohydrate diet-induced changes in very low density lipoprotein composition and structure. Diabetes 1978; 27: 1215-1229.
23. Boogaerts JR, Malone-McNeal M, Archambault-Schexnayder J, Davis R. Dietary carbohydrate induces lipogenesis and very-low-density lipoprotein synthesis. Am J Physiol 1984; 246: E79-E83.
24. Patsch W, Schonfeld G. The degree of sialylation of apoC-III is altered by diet. Diabetes 1981; 30: 530-534.
25. Tokunaga K, Bray GA, Matsuzawa Y. Improved yield of obese rats using a double coordinate system to locate the ventromedial or paraventricular nucleus. Brain Res Bull 1993; 26: 191-194.
26. Pullinger CR, North JD, Teng BB, Rifici VA, Ronhild de Brito AE, Scott J. The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by olic acid, albumin, and insulin, and measurement of mRNA half-life. J Lipid Res 1989; 30: 1065-1078.
27. Davidson NO, Carlos RC, Drewek MJ, Farmer TG. Apolipoprotein gene expression in the rat is regulated in a tissue-specific manner by thyroid hormone. J Lipid Res 1988; 29: 1511-1522.
28. Strobl W, Gorder NL, Fienup GA, Lin-Lee YC, Gotto AM Jr, Patsch W. Effect of sucrose diet on apolipoprotein biosynthesis in rat liver: Increase in apolipoprotein E gene transcription. J Biol Chem 1989; 264: 1190-1194.
29. Cohen AM, Teitebaum A. Effects of dietary sucrose and starch on oral glucose and insulin-like activity. Am J Physiol 1964; 206: 105-108.
30. Elshourbagy NA, Boguski MS, Liao WS, Jefferson LS, Gordon JI, Taylor JM. Expression of rat apolipoprotein A-IV and AI genes: mRNA induction during development and in response to glucocorticoids and insulin. Proc Natl Acad Sci USA 1985; 82: 8242-8246.