메뉴 건너뛰기




Volumn 3, Issue 3, 1997, Pages 401-407

Phase I and pharmacological study of CI-980, a novel synthetic antimicrotubule agent

Author keywords

[No Author keywords available]

Indexed keywords

MIVOBULIN ISETHIONATE;

EID: 0030887268     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (19)
  • 1
    • 0020612067 scopus 로고
    • New anticancer agents: Synthesis of 1,2-dihydropyrido[3,4-b]pyrazines: structure-activity relationships
    • Temple, C., Jr., Wheeler, G. P., Elliot, R. D., Rose, J. D., Comber, R. N., and Montgomery, J. A. New anticancer agents: synthesis of 1,2-dihydropyrido[3,4-b]pyrazines: structure-activity relationships. J. Med. Chem., 26: 91-95, 1992.
    • (1992) J. Med. Chem. , vol.26 , pp. 91-95
    • Temple Jr., C.1    Wheeler, G.P.2    Elliot, R.D.3    Rose, J.D.4    Comber, R.N.5    Montgomery, J.A.6
  • 2
    • 0020079714 scopus 로고
    • Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihdryo-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7- ylcarbamate (NSC 181928)
    • Wheeler, G. P., Bowdon, B. J., Werline, J. A., Adamson, D. J., and Temple, C. G. Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihdryo-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7- ylcarbamate (NSC 181928). Cancer Res., 42: 791-798, 1982.
    • (1982) Cancer Res. , vol.42 , pp. 791-798
    • Wheeler, G.P.1    Bowdon, B.J.2    Werline, J.A.3    Adamson, D.J.4    Temple, C.G.5
  • 3
    • 0020624384 scopus 로고
    • Biological effects and structure-activity relationships of l,2-dihydropyrido[3,4-b]pyrazines
    • Wheeler, G. P., Bowdon, B. J., Temple, C., Jr., Adamson, D. J., and Webster, J. Biological effects and structure-activity relationships of l,2-dihydropyrido[3,4-b]pyrazines. Cancer Res., 43: 3567-3575, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 3567-3575
    • Wheeler, G.P.1    Bowdon, B.J.2    Temple Jr., C.3    Adamson, D.J.4    Webster, J.5
  • 4
    • 0023139279 scopus 로고
    • Comparison of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis
    • Bowdon, B. J., Waud, W. R., Wheeler, G. P., Hain, R. H., Dansby, L., and Temple, C. G. Comparison of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis. Cancer Res., 47: 1621-1626, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 1621-1626
    • Bowdon, B.J.1    Waud, W.R.2    Wheeler, G.P.3    Hain, R.H.4    Dansby, L.5    Temple, C.G.6
  • 5
    • 0024422754 scopus 로고
    • New anticancer agents: Chiral isomers of ethyl (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido-[3,4-b]pyrazin-7-yl)-carbamate
    • Temple, C., Jr., and Rener, G. A. New anticancer agents: chiral isomers of ethyl (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido-[3,4-b]pyrazin-7-yl)-carbamate. J. Med. Chem., 32: 2089-2092, 1989.
    • (1989) J. Med. Chem. , vol.32 , pp. 2089-2092
    • Temple Jr., C.1    Rener, G.A.2
  • 6
    • 0028044792 scopus 로고
    • Inhibition of microtubules and cell cycle arrest by a new l-deaza-7,8-dihydropteridine antitumor drug CI-980, and by its chiral isomer, NSC 613863
    • de Ines, C., Leynadier, D., Barasoain, I., Peyrot, V., Garcia, P., Briand, C., Rener, G. A., and Temple, C., Jr. Inhibition of microtubules and cell cycle arrest by a new l-deaza-7,8-dihydropteridine antitumor drug CI-980, and by its chiral isomer, NSC 613863. Cancer Res., 54: 75-84, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 75-84
    • De Ines, C.1    Leynadier, D.2    Barasoain, I.3    Peyrot, V.4    Garcia, P.5    Briand, C.6    Rener, G.A.7    Temple Jr., C.8
  • 7
    • 0025297395 scopus 로고
    • Antitumor activity of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate, 2-hydroxyethanesulfonate hydrate (NSC 370147) against selected tumor systems in culture and in mice
    • Waud, W. R., Leopold, W. R., Elliot, W. L., Dykes, D. J., Laster, W. R., Jr., Temple, C. G., Jr., Harrison, S. D., Jr., and Griswold, D. P., Jr. Antitumor activity of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate, 2-hydroxyethanesulfonate hydrate (NSC 370147) against selected tumor systems in culture and in mice. Cancer Res., 50: 3239-3244, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 3239-3244
    • Waud, W.R.1    Leopold, W.R.2    Elliot, W.L.3    Dykes, D.J.4    Laster Jr., W.R.5    Temple Jr., C.G.6    Harrison Jr., S.D.7    Griswold Jr., D.P.8
  • 8
    • 1842283694 scopus 로고    scopus 로고
    • Park-Davis Pharmaceutical Research Division, Warner-Lambert Company. Investigator's Brochure. 1990
    • Park-Davis Pharmaceutical Research Division, Warner-Lambert Company. Investigator's Brochure. 1990.
  • 11
    • 0003506753 scopus 로고
    • Bethesda, MD: National Cancer Institute
    • Division of Cancer Treatment, National Cancer Institute. Guidelines for Reporting of Adverse Drug Reactions. Bethesda, MD: National Cancer Institute, 1988.
    • (1988) Guidelines for Reporting of Adverse Drug Reactions
  • 12
    • 0016823810 scopus 로고
    • "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician
    • Folstein, M. F., Folstein, S. E., and McHugh, P. R. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res., 12: 189-198, 1975.
    • (1975) J. Psychiatr. Res. , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 13
    • 0029013554 scopus 로고
    • High-performance liquid Chromatographic assay for CI-980, a novel 1-deaza-7,8-dihydropteridine anticancer agent, in human plasma and urine
    • Bullen, W. W., Whitfield, L. R., Walter, G. A., and Brodfuehrer, J. I. High-performance liquid Chromatographic assay for CI-980, a novel 1-deaza-7,8-dihydropteridine anticancer agent, in human plasma and urine. J. Chromatogr. B. Biomed. Appl., 668: 141-151, 1995.
    • (1995) J. Chromatogr. B. Biomed. Appl. , vol.668 , pp. 141-151
    • Bullen, W.W.1    Whitfield, L.R.2    Walter, G.A.3    Brodfuehrer, J.I.4
  • 14
    • 0027330403 scopus 로고
    • Podophyllotoxin, steganacin, and combrestatin: Natural products that bind at the colchicine binding site of tubulin
    • Sacken, D. L. Podophyllotoxin, steganacin, and combrestatin: natural products that bind at the colchicine binding site of tubulin. Pharmacol. & Ther., 59: 163-228, 1993.
    • (1993) Pharmacol. & Ther. , vol.59 , pp. 163-228
    • Sacken, D.L.1
  • 15
    • 0003931347 scopus 로고
    • Antitumor activity of a novel 1,2-dihydropyrido[3,4-b]pyrazine in preclinical drug-sensitive and -resistant tumors
    • Griswold, D. P., Temple, C. G., Trader, M. W., Leopold, W. R., Laster, W. R., and Dykes, D. J. Antitumor activity of a novel 1,2-dihydropyrido[3,4-b]pyrazine in preclinical drug-sensitive and -resistant tumors. Proc. Am. Assoc. Cancer Res., 27: 306, 1986.
    • (1986) Proc. Am. Assoc. Cancer Res. , vol.27 , pp. 306
    • Griswold, D.P.1    Temple, C.G.2    Trader, M.W.3    Leopold, W.R.4    Laster, W.R.5    Dykes, D.J.6
  • 19
    • 0027303694 scopus 로고
    • Extravasation injury potential of CI-980, a novel synthetic mitotic inhibitor
    • MacDonald, J. R., and Pegg, D. G. Extravasation injury potential of CI-980, a novel synthetic mitotic inhibitor. Cancer Chemother. Pharmacol., 32: 365-367, 1993.
    • (1993) Cancer Chemother. Pharmacol. , vol.32 , pp. 365-367
    • MacDonald, J.R.1    Pegg, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.