Effects of the glucocorticoid II receptor antagonist mifepristone on hypertension in the obese Zucker rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1503-1508

  Clapham, John C ^a   Turner, Nicholas C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; CORTICOSTERONE; CORTICOSTERONE 21 ACETATE; GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; INSULIN; MIFEPRISTONE; RENIN;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG EFFECT; HYPERTENSION; INSULIN BLOOD LEVEL; MALE; NONHUMAN; OBESITY; ORAL DRUG ADMINISTRATION; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ALDOSTERONE; ANIMALS; BLOOD PRESSURE; CORTICOSTERONE; HYPERTENSION; MALE; MIFEPRISTONE; OBESITY; RATS; RATS, ZUCKER; RECEPTORS, GLUCOCORTICOID;

EID: 0030886983     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. AGARWAL, M. K., HAINQUE, B., MOUSTAID, N. AND LAZER, G.: Glucocorticoid antagonists. FEBS Lett. 217: 221-226, 1987.
2. ALARRAYED, F., HARTMAN, A. D. AND PORTER, J. R.: Is there a role for the adrenals in the development of hypercholesterolemia in Zucker fatty rats. Am. J. Physiol. 263: E287-E295, 1992.
3. BRAY, G. A. AND YORK, D. A.: Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 59: 719-809, 1979.
4. BRAY, G. A., FISLER, J. AND YORK, D. A.: Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Front. Neuroendocrinol. 11: 128-181, 1990.
5. BROGDEN, R. N., GOA, K. L. AND FAULDS, D.: Mifepristone. Drugs 45: 384-409, 1993.
6. BUNAG, R. D. AND BUTTERFIELD, J.: Tail-cuff blood pressure measurement without preheating in awake rats. Hypertension 4: 898-903, 1984.
7. BUNAG, R. D.: Measurement of blood pressure in rats. In Handbook of Hypertension Volume 4, ed. by W. deJong W, pp 1-11, Elsevier, Amsterdam, 1984.
8. CASTTONGUAY, T. W.: Glucocorticoids as modulators in the control of feeding. Brain. Res. Bull. 27: 423-428, 1991.
9. CORRY, D. B. ANB TUCK, M. L.: Pathogenesis of hypertension in diabetes. J. Cardiovascular Pharmacol. 28: S6-S15, 1996.
10. CRARY, G. S., SWAN, S. K., O'DONNELL, M. P., KASISKE, B. L., KATZ, S. A. AND KEANE, W. F.: The angiotensin II receptor antagonist losartin reduces blood pressure but not renal injury in obese Zucker rats. J. Am. Soc. Nephrol 6: 1295-1299, 1995.
11. DALY, P. A. AND LANDSBERG, L.: Hypertension in obesity and NIDDM. Role of insulin and sympathetic nervous system. Diabetes Care 14: 240-248, 1991.
12. DEFRONZO, R. A.: Insulin resistance: The metabolic link between non-insulin-dependent diabetes mellitus, obesity, hypertension, dyslipidaemia and atherosclerotic cardiovascular disease. Curr. Opin. Cardiol. 5: 586-593, 1990.
13. FERRANNINI, E., HAFFNER, S. M. AND STERN, M. P.: Essential hypertension and insulin-resistant state. J. Cardiovasc. Pharmacol. 15: S18-S25, 1990.
14. FLETCHER, J. M.: Effects of adrenalectomy before weanling and short- or long-term glucocorticoid administration on the genetically obese Zucker rat. Biochem. J. 238: 459-463, 1986.
15. FREEDMAN, M. R., HORWITZ, B. A. AND STERN, J. S.: Effect of adrenalectomy and glucocorticoid replacement on development of obesity. Am. J. Physiol. 250: R595-R607, 1986.
16. GRUNFELD, J. P., ELOY, L., MOURA, A. M., GANEVAL, D., RAMOS-FRENDO, B. AND WORCEL, M.: Effects of antiglucocorticoids on glucocorticoid hypertension in the rat. Hypertension 7: 292-299, 1985.
17. GUPTA, P., FRANCO-SAENZ, R. AND MULROW, P. J.: Locally generated angiotensin II in the adrenal gland regulates basal, corticotropin and potassium stimulated aldosterone secretion. Hypertension 25: 443-448, 1995.
18. HAFFNER, S. M., VALDEZ, R. A., HAZUDA, H. P., MITCHELL, B. D., MORALES, P. A. AND STERN, M. P.: Prospective analysis of the insulin-resistance syndrome (Syndrome X). Diabetes 41: 715-722, 1992.
19. HARKER, C. T., O'DONNELL, M. P., KASISKE, B. L., KEANE, W. F. AND KATZ, S. A.: The renin-angiotensin system in the type II diabetic obese Zucker rat. J. Am. Soc. Nephrol. 4: 1354-1361, 1993.
20. INIGAMI, T., MIZUNO, K., NARUSE, M., NAKAMURA, M., NARUSE, K. AND HOFMANN, L. H.: Active and inactive renin in the adrenal. Am. J. Hypertens. 2: 311-319, 1989.
21. KASISKE, B. L., O'DONNELL, M. P. AND KEANE, W. F.: The Zucker rat model of obesity, Insulin resistance, hyperlipidaemia and renal injury. Hypertension 19: I-110-I-115, 1992.
22. KISSEBAH, A. H. AND KRAKOWER, G. R.: Regional adiposity and morbidity. Physiol. Rev. 74: 761-811, 1994.
23. KURTZ, T. W., MORRIS, R. C. AND PERSHADSINGH, H. A.: The Zucker fatty rat as a genetic model of obesity and hypertension. Hypertension 13: 896-901, 1989.
24. LANGLEY, S. C. AND YORK, D. A.: Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats. Am. J. Physiol. 259: R539-R544, 1990.
25. LEVIN, B. E., TRISCARI, J. AND SULLIVAN, A. C.: Studies on the origins of abnormal sympathetic function in obese Zucker rats. Am. J. Physiol. 245: E87-E93, 1983.
26. LJUTIC, D., RAOS, V. AND BIOCIC, M.: Aldosterone and blood pressure in obese subjects during short term starvation. Acta Med. Croatica 49: 165-168, 1995.
27. MANTERO, F. AND BOSCARO, M.: Glucocortcoid-dependent hypertension. J. Steroid Biochem. Mol. Biol. 43: 409-413, 1992.
28. MARIN, P., DARIN, N., AMEMIYA, T., ANDERSONN, B., JERN, S. AND BJORNTORP, P.: Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 41: 882-886, 1992.
29. MULROW, P. J. AND FRANCO-SAENZ, R.: The adrenal renin-angiotensin system: A local hormonal regulator of aldosterone production. J. Hypertens. 14: 173-176, 1996.
30. OKADA, S., YORK, D. A. AND BRAY, G. A.: Mifepristone (RU486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity. Am. J. Physiol. 262: R1106-R1110, 1992.
31. PASQUALI, R., CANTOBELLI, S., CASIMIRRI, F., CAPELLI, M., BORTOLUZZI, L., FLAMIA, R., LABATE, A. M. M. AND BARBARA, L.: The hypothalamic-pituitary-adrenal axis in obese women with different pattern of body fat distribution. J. Clin. Endocrinol. Metab. 77: 341-346, 1993.
32. PERSHADSINGH, H. A., SZOLLOSI, J., BENSON, S., HYUN, W. C., FEUERSTEIN, B. G. AND KURTZ, T. W.: Effects of ciglitazone on blood pressure and intracellular calcium metabolism. Hypertension 21: 1020-1023, 1993.
33. PHILIPS, M. I., SPEAKMAN, E. A. AND KIMURA, B.: Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Regul. Peptides 43: 1-20, 1993.
34. PHILIPS, M. S., LIU, Q., HAMMOND, H. A., DUGAN, V., HEY, P. J., CASKEY, C. T. AND HESS, J. F.: Leptin receptor missense mutation in the fatty Zucker rat. Nature Genet. 13: 18-19, 1996.
35. PKOVENCHER, P. H., SALTIS, J. AND FUNDER, J. W.: Glucocorticoids but not mineralocorticoids modulate endothelin-1 and angiotensin II binding in SHR vascular smooth muscle cells. J. Steroid Biochem. Mol. Biol. 52: 219-225, 1995.
36. RAMIREZ, G., GANGULY, A. AND BRUGGEMYER, C. D.: Acute effect of captopril on aldosterone secretory responses to endogenous or exogenous adrenocorticotropin. J. Clin. Endocrinol. Metab. 66: 46-50, 1988.
37. REAVEN, G. M.: Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
38. ROCCHINI, A. P., MOOREHEAD, C. P., DEREMER, S. AND BONDIE, D.: Pathogenesis of weight-related changes in blood pressure in dogs. Hypertension 13:922-928, 1989.
39. SCHMITZ, P. G., O'DONNELL, M. P., KASISKE, B. L., KATZ, S. A. AND KEANE, W. F.: Renal injury in obese Zucker rats: Glomerular hemodynamic alterations and effects of enalapril. Am. J. Physiol. 263: F496-F502, 1992.
40. TURNER, N. C., GUDGEON, C. AND TOSELAND, N.: Effects of genetic hyperinsulinaemia on vascular reactivity, blood pressure and renal structure in the Zucker rat. J. Cardiovasc. Pharmacol. 26: 714-720, 1995.
41. WAJCHENBERG, L. B., MALERBIT, D. A., ROCHA, M. S., LERARIO, A. C. AND SANTOMAURO, A. T. M. G.: Syndrome X: A syndrome of insulin resistance. Epidemiological and clinical evidence. Diab. Metab. Rev. 10: 19-29, 1994.
42. WALKER, B. R. AND EDWARDS, C. R.: New mechanisms for corticosteroid-induced hypertension. Br. Med. Bull. 50: 342-355, 1994.
43. WALLENSTEIN, S., ZUCKER, C. L. AND FLEISS, J. L.: Some statistical methods useful in circulation research. Circ. Res. 47: 1-8, 1980.
44. YOSHIOKA, S., NISHINO, H., SHIRAKI, T., IKEDA, K., KOIKE, H., OKUNO, A., WADA, M., FUJIWARA, T. AND HORIKOSHI, H.: Antihypertensive effects of CS-045 treatment in obese Zucker rats. Metabolism 42: 75-80, 1993.