Synthesis and structures of isomerically pure bis-(alkylbenzo) crown ethers

Tetrahedron

Volumn 53, Issue 40, 1997, Pages 13567-13582

  Sachleben, Richard A ^a   Bryan, Jeffrey C ^a   Lavis, Jerome M ^a   Starks, Courtney M ^a   Burns, John H ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROWN ETHER DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS; X RAY DIFFRACTION;

EID: 0030886716     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)00932-0     Document Type: Article

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36. c2)/3.
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41. Addition of sodium hydroxide pellets at ∼100 °C results in rapid dissolution of the base without excessive heating of the reaction mixture. Addition at lower temperatures (<100°C) requires more time for the sodium hydroxide to dissolve, while addition at higher temperature (∼150°C) results in violent reaction of the base and overheating of the reaction mixture
42. The bis-formyl ester hydrolized sufficiently upon work-up and chromatography to preclude obtaining good spectral data or elemental analysis. The NMR spectra of the crude product were consistant with the proposed structure.