A convenient synthesis of R-(-)-carnitine from R-(-)-epichlorohydrin

Tetrahedron Asymmetry

Volumn 8, Issue 16, 1997, Pages 2663-2665

  Kabat, Marek M ^a   Daniewski, Andrzej R ^a   Burger, Walter ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; EPICHLOROHYDRIN;

ARTICLE; DRUG SYNTHESIS; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030886437     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00324-8     Document Type: Article

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28. 3): 38.7, 49.4, 70.7, 118.6, 133.3.
29. 18NO (M-Cl) calcd 144.1388, observed 144.1390.
30. 18NO (M-OH) calcd 144.1388, observed 144.1391.
31. 2O), was obtained from 2-propane/acetone (1:1).
32. The optical rotation of carnitine (1) as function of its concentration and temperature has previously been reported; cf. Ref. 7b.