Normal thyroxine and elevated thyrotropin concentrations: Evolving hypothyroidism or persistent euthyroidism with reset thyrostat

Journal of Endocrinological Investigation

Volumn 20, Issue 6, 1997, Pages 319-326

  Kabadi, U M ^a   Cech, R ^b  

^a Jr Hospital of Cook County   (United States)

^b NONE

Author keywords

Pituitary thyroid axis; Reset thyrostat; Subclinical or evolving hypothyroidism

Indexed keywords

IODINE 131; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; EUTHYROIDISM; FEMALE; FOLLOW UP; HUMAN; HYPOPHYSIS THYROID SYSTEM; HYPOTHYROIDISM; LIFESPAN; LIOTHYRONINE BLOOD LEVEL; MALE; RANDOMIZED CONTROLLED TRIAL; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

EID: 0030886363     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03350310     Document Type: Article

References (39)

1. Cooper D.S., Halpern R., Wood L.C., Levin A.A., Ridgway E.C. L-Thyroxine therapy in "subclinical hypothyroidism": A double-blind, placebo-controlled trial. Ann. Intern. Med. 1001: 18, 1984.
2. Nystrom E., Ca K., Fager G., Wikkelso C., Lunberg P.A., Lindstedt G. A double-blind cross-over 12-month study of L-thyroxine treatment of women with "subclinical" hypothyroidism. Clin. Endocrinol. (Oxf.) 29: 63, 1988.
3. Bastenie P.A., Vanhaelst L., Neve P. Coronary artery disease in hypothyroidism: Observation in preclinical myoedema. Lancet 2: 1221, 1967.
4. Fowler R.B.S., Swale J., Andrews H. Hypercholesterolemia in borderline hypothyroidism: Stage of premyxoedema. Lancet 2: 488, 1970.
5. Bastenie P.A., Vanhaelst L., Bonnyns L., Neve P., Staquet M. Preclinical hypothyroidism: A risk factor for coronary-heart disease. Lancet 1: 203, 1971.
6. Evered D.C., Ormston B.J., Smith P.A., Hall R., Bird T. Grades of hypothyroidism. Br. Med. J. 1: 657, 1973.
7. Tunbridge W.M.G., Brewis M., French J.M., Appleton D., Bird T., Clark F., Evered D.C., Evans J.G., Hall R., Smith P., Stephenson J., Young E. Natural history of autoimmune thyroiditis. Br. Med. J. (Clin. Res.) 282: 258, 1981.
8. Gordin A., Lamberg B-A. Spontaneous hypothyroidism in symptomless autoimmune thyroiditis: A long-term follow-up study. Clin. Endocrinol. (Oxf.) 15: 537,1981.
9. Tibaldi J., Barzel U.S. Thyroxine supplementation for the prevention of clinical hypothyroidism. Am. J. Med. 79: 241, 1985.
10. Sawin C.T., Chopra D., Azizi F., Mannix U.E., Bacharach P. The aging thyroid: Increased prevalence of elevated serum thyrotropin levels in the elderly. JAMA 242: 247, 1979.
11. Tunbridge W.M.G., Evered D.C., Hall R., Appleton D., Brewis M., Clark F., Evans J.G., Young E., Bird T., Smith P.A. The spectrum of thyroid disease in a community: The Wickham survey. Clin. Endocrinol. (Oxf.) 7: 481, 197
12. Lipson A., Nickoloff E.L., Hsiung Has T., Kasecamp W.R., Drew H.M., Shakir R., Wagner H.N. Jr. A study of age-dependent changes in thyroid function tests in adults. J. Nucl. Med. 20: 1124, 1979.
13. Rosenthal M.J., Sanchez C.J. Thyroid disease in the elderly-missed diagnosis or over diagnosis? West J. Med. 143: 643, 1985.
14. Bahemuka M., Hodkinson H.M. Screening for hypothyroidism in elderly inpatients. Br. Med. J. 2: 601, 1975.
15. Atkinson R.L., Dahms W.T., Fisher D.A., Nichols A.L. Occult thyroid disease in an elderiy hospitalized population. J. Gerontol. 33: 372, 1978.
16. Falkenberg M., Kagedal B., Norr A. Screening of an elderly female population for hypo-and hyperthyroidism by use of a thyroid hormone panel. Acta Med. Scand. 274: 361, 1983.
17. Rosenthal M.J., Hunt W.C., Garry P.J., Goodwin J.S. Thyroid failure in the elderly: Microsomal antibodies as discriminant for therapy. JAMA 258: 209,1978.
18. Rosenbaum R.L., Barzel U.S. Clinical hypothyroidism in the elderly. A preventable disorder? J. Am. Geriatr. Soc. 29: 221, 1981.
19. Caren P.H., Calazel C., Parra H.J., Hoff M., Loavet J.P. Decreased HDL cholesterol in "subclinical hypothyroidism": The effect of L-thyroxine therapy. Clin. Endocrinol. (Oxf.) 33: 519, 1990.
20. Arem R., Patsch W. Lipoprotein and apolipoprotein levels in "subclinical hypothyroidism". Effect of levothyroxine therapy. Arch. Intern. Med. 150: 2097, 1990.
21. Kung A.W.C., Pang R.W., Janus E.D. Elevated lipoprotein (a) in patients with subclinical hypothyroidism. Clin. Endocrinol. (Oxf.), 43: 445, 1995.
22. Kabadi U.M. "Subclinical hypothyroidismn": Natural course of the syndrome during a prolonged follow-up study. Arch. Intern. Med. 153: 957,1993.
23. Kabadi U.M. Normal thyrotrophin response to intravenous thyrotrophin releasing hormone administration: The best index of optimal L-thyroxine therapy in primary hypothyroidism. Postgrad. Med. J. 61: 685, 1985.
24. Kabadi U.M., Rosman P.M. Lack of influence of aging on hypothalamic pituitary thyroid axis in normal subjects. J. Clin. Exper. Gerontol., 9: 189, 1987.
25. Wartofsky L., Burman K. Alteration in thyroid function in patients with systemic illness: The "euthyroid sick syndrome". Endocr. Rev. 3: 164, 1982.
26. Helfand M., Crapo L.M. Screening for thyroid disease. Ann. Intern. Med. 112: 840, 1990.
27. Parle J.V., Franklyn J.A., Cross K.W., Jones S.C., Sheppard M.C. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin. Endocrinol. (Oxf.) 34: 77, 1991.
28. Wood J.M., Gordon D.L., Rudinger A.N., Brooks M.M. Artifactual elevation of thyroid-stimulating hormone. Am. J. Med. 90: 261, 1991.
29. Helfand M., Crapo L.M. Screening for thyroid disease. Ann. Intern. Med. 112: 840, 1990.
30. Kabadi U.M., Rosman P.M. Thyroid hormone indices in adult healthy subjects: No influence of aging. J. Am. Geriatr. Soc. 36: 312, 1988.
31. Vanderpump M.P.J., Tunbridge W.M.G., French J.M., Appleton D., Bates D., Clarks F., Evans J.G., Hasan D.M., Rodgers H., Tunbridges F., Young E.T. The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham Survey. Clin. Endocrinol. (Oxf.) 43: 55, 1995.
32. Mandel S.J., Brent G.A., Larsen P.P. Levothyroxine therapy in patients with thyroid disease. Ann. Intern. Med. 119: 492, 1993.
33. Roti E., Minelli R., Gardini E., Braverman L.E. The use and misuse of thyroid hormone. Endocr. Rev. 14: 401, 1993.
34. Baker B.A., Hossen G., Markowitz H. Correlation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease. Ann. J. Med. 74: 941, 1983.
35. Wilson R., McKillop J.H., Crocket G.T., Pearson C., Jenkins C., Burns F., Burnett A.K., Thomson J.A. The effect of lithium therapy on parameters thought to be involved in the development of autoimmune thyroid disease. Clin. Endocrinol. (Oxf.), 34: 357, 1991.
36. Peterson V.B., Mcgregor A.M., Belchetz P.E., Elkeles R.S., Hall R. The secretion of thyrotropin with impaired biological activity in patients with hypothalamic-pituitary disease. Clin. Endocrinol. (Oxf.) 8: 397, 1978.
37. Faglia G., Bitensky L., Pinchera A., Ferrari C., Paracchi A., Beck-Peccoz P., Ambrosi B., Spada A. Thyrotropin secretion in patients with central hypothyroidism: Evidence for reduced biological activity of immunoreactive thyrotropin. J. Clin. Endocrinol. Metab. 6: 989, 1979.
38. Beck-Peccoz P., Amr S., Menezes-Ferreira M., Faglia G., Weintraub B.D. Decreased receptor binding of biologically inactive thyrotropin in central hypothyroidism. N. Engl. J. Med. 312: 1085, 1985.
39. Horimoto M., Nishikawa M., Ishihara T., Yoshikawa N., Yoshimura M., Inada M. Bioactivity of thyrotropin (TSH) in patients with central hypothyroidism: Comparison between in vivo 3,5,3'-Triiodothyronine response to TSH and in vivo bioactivity of TSH. J. Clin. Endocrinol. Metab. 80: 1124, 1995.