Pharmacokinetics and pharmacodynamics of 4-aminopyridine in awake guinea pigs

Drug and Chemical Toxicology

Volumn 20, Issue 3, 1997, Pages 151-172

  Capacio, B R ^a   Chang, F C T ^a   Spriggs, D ^a   Byers, C E ^a   Matthews, R L ^a   Benton, B J ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; POTASSIUM CHANNEL; SAXITOXIN; TETRODOTOXIN;

ANIMAL MODEL; ARTICLE; BREATHING RATE; CARDIOTOXICITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; ELECTROCARDIOGRAM; ELECTROCORTICOGRAPHY; ELECTROMYOGRAM; ELECTROPHYSIOLOGY; EXCITABLE MEMBRANE; GUINEA PIG; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NEUROTRANSMITTER RELEASE; NONHUMAN;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0030885343     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.3109/01480549709003876     Document Type: Article

References (22)

1. Glover, W.E. (1982). The aminopyridines. Gen. Pharmacol., 13, 259-285.
2. Lundh, H., Nilsson, O., Rosen, I. (1990). Current therapy of the Lambert-Eaton myasthenic syndrome. Prog. Brain Res., 84, 163-170.
3. Ball, A.P., Hopkinson, R.B., Farrell, I.D., Hutchison, J.G.P., Paul, R., Watson, R.D.S., Page, A.J.F., Parker, R.G.F., Edwards, C.W., Snow, M., Scott, D.K., Leone-Ganado, A., Hastings, A., Ghosh, A.C., Gilbert, R.J. (1979). Human botulism caused by Clostridium botulinum type E: The Birmingham outbreak. Quarterly Journal of Medicine, New Series XLVIII, 191 473-491.
4. Simpson, L.L. (1986). A preclinical evaluation of aminopyridines as putative therapeutic agents in the treatment of botulism. Infect. Immun., 52, 858-862.
5. Van Diemen, H.A.M., Polman, C.H., Koetsier, J.C., Van Loenen, A.C., Nauta, J.J.P., Bertelsmann, F.W. (1993). 4-Aminopyridine in patients with multiple sclerosis: Dosage and serum levels related to efficacy and safety. Clin. Neuropharmacol. 16, 195-204.
6. Bever, C. T. (1994). The current status of studies of aminopyridines in patients with multiple sclerosis. Ann. Neurol. 36(suppl), S118-S121.
7. Bever, C. T., Young, D., Anderson, P.A., Krumholz, A., Conway, K., Leslie, J., Eddington, N., Plaisance, K.I., Panitch, H.S., Dhib-Jalbut, S., Fossler, M.J., Devane, J., Johnson, K.P. (1994). The effects of 4-aminopyridine in multiple sclerosis patients: Results of a randomized, placebo-controlled, double-blind, concentration-controlled, crossover trial. Neurology, 44, 1054-1059.
8. Santamaria, D., Rios, C., Kravzov, J. Altagracia, M. (1993). 4-Aminopyridine antagonizes lethality induced by saxitoxin in mice. Proc. West Pharmacol Soc. 36, 193-195.
9. Benton, B.J., Spriggs, D., Capacio, B.R., Chang, F.-C.T. (1995). 4-Aminopyridine Antagonizes the Lethal Effects of Saxitoxin (STX) and Tetrodotoxin (TTX). International Society on Toxicology (5th Pan American Symposium on Animal, Plant and Microbial Toxins. Frederick, MD July-August 1995, p 217.
10. Chang, F.-C. T, Benton, B.J., Capacio, B.R., Spriggs, D. (1995). 4-Aminopyridine (4-AP) reverses the sublethal effects of saxitoxin (TTX) and tetrodotoxin (TTX). FASEB J. 9(4), A3853.
11. Chang, F.-C. T, Harper, R.M. (1989). A procedure for chronic recording of diaphragmatic electromyographic activity. Brain Res. Bull., 22(3), 561-563.
12. Capacio, B.R., Byers, C.E., Matthews, R.L., Chang, F.-C.T. A method for determining 4-aminopyridine in plasma: Pharmacokinetics in anesthetized guinea pigs after intravenous administration. Biomedical Chromatography, 10, 111-116, (1996).
13. Childers, D.G. (1978). Modern Spectrum Analysis, IEEE, New York.
14. Fastier, F.N., McDowall, M.A. (1958). A comparison of the pharmacological properties of the three isomeric aminopyridines. Aust. J. Exp. Biol. 36, 365-372.
15. Shaw, F.H , Bentley, G. (1952). Morphine antagonism. Nature 169, 712-713.
16. Shaw, F.H , Bentley, G. (1955). Morphine antagonism. Aust. J. Exp. Biol. 33, 143-151.
17. Sia, R.L., Salt, P.J., Langreher, D., Agoston, S., Erdmann, W. (1979). Effects of the analeptic drug, 4-aminopyridine, upon post-operative respiratory depression in patients. Acta Anaesth. Belg. (suppl.) 30, 195-199.
18. Folgering, H., Rutten, J., Agoston, S. (1979). Stimulation of phrenic nerve activity by an acetylcholine releasing drug: 4-aminopyridine. Pflügers Arch. 379, 181-185.
19. Bowman, W.C., Marshall, R.J., Rodger, I.W., Savage, A.O. (1981). Actions of 4-aminopyridine on the cardiovascular systems of anaesthetized cats and dogs. Br. J. Anaesth., 53, 555-565.
20. Foldes, F.F., Braak, G., Van Wezel H., Huynen, R., Agoston, S., Crul, J. (1976). The interaction of 4-aminopyridine with neuromuscular blocking agents in the rat. Proc. Am Soc. Anesth. 561-562.
21. Yanagisawa, T., Satoh, K., Taira, N. (1978). Excitation of autonomic nerves by 4-aminopyridine in the isolated blood-perfused sino-atrial node preparation of the dog. Eur. J. Pharmac. 49, 189-192.
22. Lemeignan, M , Millart, H., Lamiable, D., Molgo, J., Lechat, P. (1984). Evaluation of 4-aminopyridine and 3,4-diaminopyridine penetrability into cerebralspinal fluid in anesthetized rats. Brain Res. 304, 166-169.