Concurrent radio-chemotherapy in N2 non small cell lung cancer: Interim analysis

European Journal of Cardio-thoracic Surgery

Volumn 12, Issue 3, 1997, Pages 366-371

  Granone, Pierluigi ^a   Margaritora, Stefano ^a   Cesario, Alfredo ^a   Bonatti, Pierluigi ^a   Galetta, Domenico ^a   Picciocchi, Aurelio ^a  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Induction therapy; Lung cancer; Radio chemotherapy

Indexed keywords

CARBOPLATIN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE RADIOTHERAPY; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; TREATMENT OUTCOME;

ACTUARIAL ANALYSIS; ADULT; AGED; ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARCINOMA, NON-SMALL-CELL LUNG; CHEMOTHERAPY, ADJUVANT; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PNEUMONECTOMY; PREOPERATIVE CARE; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; SURVIVAL ANALYSIS;

EID: 0030883471     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1010-7940(97)00206-6     Document Type: Article

References (20)

1. Bonomi P. Combined modality treatment for non small cell lung cancer. Presented at the Thoracic Postgraduate Course. 74th Congress of the American College of Surgeons Clinical Congress, Chicago, October 24, 1988.
2. Burkes RL, Ginsberg RJ, Shepherd FA, Blackstein ME, Goldberg ME, Waters P, Patterson A, Todd T, Pearson FG, Cooper J, Jones D, Lockwood G. Induction chemotherapy with mitomycin, vindesine and cisplatin for stage III unresectable non small cell lung cancer: Results of the Toronto Phase II trial. J Clin Oncol 1992;10:580-6.
3. Faber LP, Kittle CF, Warren WH, Bonomi PD, Taylor IV S, Reddy S, Lee MS. Preoperative chemotherapy and irradiation for stage III non small cell lung cancer. Ann Thorac Surg 1988;45:370-9.
4. Fischer JR, Manegold C, Bulzebruck H, Vogt Moykopf I, Drings P. Induction chemotherapy with and without recombinant human granulocyte colony stimulating factor support in locally advanced stage III A/B Non Small Cell Lung Cancer. Semin Oncol 1994;21(3):20-7.
5. Goldstraw P, Mannam GC, Kaplan DK, Michail P. Surgical management of non small cell lung cancer with ipsilateral mediastinal node metastasis (N2 disease). J Thorac Cardiovasc Surg 1994;107:19-28.
6. Green MR. Sequential chemotherapy and radiotherapy for initial management of stage IIIa and stage IIIb non small cell lung cancer-induction therapy. Lung Cancer 1991;7:77-84.
7. Kirn DH, Lynch TJ, Mentzer SJ, Lee TH, Strauss GM, Elias AD, Skarin AT, Sugarbaker DJ. Multimodality therapy of patients with stage IIIa N2 non small cell lung cancer. Impact of preoperative chemotherapy on resectability and downstaging. J Thorac Cardiovasc Surg 1993;106:696-702.
8. Le Chevalier T, Arrigada R, Quoix E. Impact of chemotherapy (CT) on survival of locally advanced non small cell lung cancer: results of a randomized study of 353 patients. Lung Cancer 1991;7:159.
9. Martini N, Flehinger BJ. The role of surgery in N2 lung cancer. Surg Clin North Am 1987;67:37-49.
10. Martini N, Kris MG, Flehinger BJ, Gralla RJ, Bains MS, Burt ME, Heelan R, McCormack P, Pisters KMW, Rigas J, Rusch VW, Ginsberg RJ. Preoperative chemotherapy for stage IIIa (N2) lung cancer: the Sloan Kettering experience with 136 patients. Ann Thorac Surg 1993;55:1365-74.
11. Mathisen DJ, Wain JC, Wright C, Choi N, Carey R, Hilgenber A, Grossbard M, Lynch T, Grillo H. Assessment of preoperative accelerated radiotherapy and chemotherapy in stage IIIa (N2) non small cell lung cancer. J Thorac Cardiovasc Surg 1996;111(1):123-33.
12. Pass HI, Pogrebniak HW, Steinberg SM, Mulshine J, Minna J. Randomized trial of neoadjuvant therapy for lung cancer: interim analisys. Ann Thorac Surg 1992;53:992-8.
13. Patterson GA, Piazza D, Pearson FG. Significance of metastatic disease in subaortic lymph nodes. Ann Thorac Surg 1987;43:155.
14. Pearson F.G. Management of Stage III disease. Mediastinal adenopathy: the N2 lesion. In: Delane NC, Eschapasse H, editors. International trends in general thoracic surgery, vol 1: Lung Cancer. Philadelphia: WB Saunders, 1985.
15. Rosell R, Gomez-codina J, Camps C, Maestre J, Padille J, Canto' A, Mate JL, Li S, Roig J. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non small cell lung cancer. N Engl J Med 1994;330:153-8.
16. Roth JA, Fosella F, Komaki R. A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIa non small cell lung cancer. J Natl Cancer Inst 1994;86:673-80.
17. Rusch VW, Albain KS, Crowley JJ, Rice TW, Lonchyna V, Mckenna R, Livingston RB, Griffin BR, Benfield JR. Surgical resection of stage IIIa and Stage IIIb non small cell lung cancer after concurrent induction chemoradiotherapy. J Thorac Cardiovasc Surg 1993;105:97-103.
18. Shields T. The significance of ipsilateral mediastinal lymph node metastasis (N2 disease) in non small cell carcinoma of the lung. J Thorac Cardiovasc Surg 1990;99:48-53.
19. Sugarbaker DJ, Herndon J, Kohman LJ. Results of cancer and leukemia group B protocol 3935. J Thorac Cardiovasc Surg 1991;109:473-85.
20. Watanabe Y, Shimizu J, Oda M. Aggressive surgical intervention in N2 non-small cell carcinoma of lung with mediastinal lymph node metastases. Ann Thorac Surg 1991;51:253-61.