Enhanced generation of monocyte tissue factor and increased plasma prothrombin fragment1+2 levels in patients with polycythemia vera: Mechanism of activation of blood coagulation

American Journal of Hematology

Volumn 56, Issue 1, 1997, Pages 5-11

  Kornberg, Abraham ^a,b   Rahimi Levene, Naomi ^a,b   Yona, Rivka ^a,b   Mor, Abraham ^a,b   Rachmilewitz, Eliezer A ^c  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Monocyte; Polycythemia; Polycythemia vera; Thromboplastin (tissue factor); Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; PROTHROMBIN; THROMBOPLASTIN;

ARTICLE; BLOOD CLOTTING; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERCOAGULABILITY; MONOCYTE; POLYCYTHEMIA VERA; PRIORITY JOURNAL; THROMBOGENICITY;

ADULT; AGED; BLOOD COAGULATION; HUMANS; MIDDLE AGED; MONOCYTES; PEPTIDE FRAGMENTS; POLYCYTHEMIA VERA; PROTHROMBIN; THROMBOPLASTIN;

EID: 0030883109     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199709)56:1<5::AID-AJH2>3.0.CO;2-U     Document Type: Article

References (37)

1. Anger B, Haug U, Seidler R, Heimpel H: Polycythemia vera. A clinical study of 141 patients. Blut 59:493-500, 1989.
2. Perkins J, Israels MC, Wilkinson JF: Polycythemia vera. Clinical studies on a series of 127 patients managed without radiation therapy. Q J Med 33:499-518, 1964.
3. Gruppo Italiano Studio Policitemia: Polycytemia vera. The natural history of 1,213 patients followed for 20 years. Ann Intern Med 123: 656-664, 1995.
4. Burge PS, Johnson WS, Prankland TAJ: Morbidity and mortality in pseudopolycythaemia. Lancet 1:1266-1269, 1975.
5. Messinezy M, Pearson TC: Apparent polycythemia: Diagnosis, pathogenesis and management. Eur J Haematol 51:125-131, 1993.
6. Pearson TC, Wetherly-Mein G: Vascular occlusive episodes and venous haematocrit in primary proliferative polycytaemia. Lancet 2: 1219-1222, 1978.
7. Pearson TC: Rheology of the absolute polycythaemias. In Lowe GPO (ed): "Blood Rheology and Hyperviscosity Syndromes." Bailliere Tidwell, London 1987, pp 637-664.
8. Wehmeier A, Fricke S, Scharf RE, Schneider W: A prospective study of haemostatic parameters in relation to the clinical course of myeloproliferative disorders. Eur J Hematol 45:191-197, 1990.
9. Angelina C, Ellman L: Activation of the coagulation system in polycythemia vera. Blood 47:669-678, 1996.
10. Edwards RL, Rickles FR: Macrophage procoagulant. Prog Haemost Throm 7:183-199, 1984.
11. Edwards RL, Rickles FR: The role of leukocytes in the activation of blood coagulation. Sem Hematol 29:202-212, 1992.
12. 1+2 fragment and thrombin antithrombin complex. Blood 59:1086-1097, 1982.
13. Bauer KA, Rosenberg RD: The pathophysiology of the prethrombitic state in humans: Insights gained from studies using markers of hemostatic system activation. Blood 70:343-350, 1987.
14. Mannucci PM, Giangrande PLF: Detection of the prethrombotic state due to procoagulent imbalance. Eur J Haematol 48:65-69, 1982.
15. Wasserman LR: The management of polycythaemia vera. Br J Haematol 21:371-376, 1971.
16. Kornberg A, Treves A, Rachmilewitz EA, Fibach E: Generation of procoagulation activity (PCA) by phorbolesters-induced macrophages derived from a leukemic promelocytic cell line (HL-60). Blood 59: 1061-1065, 1982.
17. Kornberg A, Treves A, Rachmilewitz EA, Fibach E: Generation of procoagulant activity (PCA) by macrophage-like cells derived from acute and chronic myeloid leukemia cells in response to phorbol esters. Scand J Haematol 31:102-108, 1983.
18. Kornberg A, Catane R, Peller S, Kaufman S, Fridkin M: Tuftsin induces tissue factor-like activity in human mononuclear cells and in monocytic cell lines. Blood 76:814-819, 1990.
19. Kornberg A, Blank M, Kaufman S, Shoenfeld Y: Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J Immunol 153:1328-1332, 1994.
20. Wieczorek I, MacGregor IR, Prescott RJ, Lulan CA: The fibrinolytic system and protein C and S in treated polycythaemia rubera vera. Blood Coag Fibrinol 3:823-826, 1992.
21. Bucalossi A, Marotta G, Bigazzi C, Galieni P, Dispensa E: Reduction of antithrombin III, protein C, and protein S levels and activated protein C resistance in polycythemia vera and essential thrombocythemic patients with thrombosis. Am J Hematol 52:14-20, 1996.
22. Rickles FR, Levin J, Hardin JA, Barr CF, Conrad ME Jr: Tissue factor generation by human mononuclear cells. Effects of endotoxin and dissociation of tissue factor generation from mitogenic response. J Lab Clin Med 89:792-803, 1977.
23. Conkling PR, Greenberg CS, Weinberg JB: Tumor necrosis factor induces tissue factor-like activity in human leukemic cell line U937 and peripheral blood monocytes. Blood 72:128-133, 1988.
24. Muhlfelder TW, Niemetz J, Kreutzer D, Deebe D, Ward FA, Rosenfeld SI: C5 chemotactic fragment induces leukocyte production of tissue factor activity. J Clin Invest 63:147-150, 1979.
25. Rothberger H, Zimmerman TS, Spiegelberg HL, Vaughan JH: Leucocyte procoagulant activity. Enhancement of production in vitro by IgG and antigen-antibody complexes. J Clin Invest 59:549-557, 1977.
26. Edwards RL, Rickles FR, Cronlund M: Abnormalities of blood coagulation in patients with cancer. Mononuclear cell tissue factor generation. J Lab Clin Med 98:917-928, 1981.
27. Edwards RL, Levine JR, Green R, Duffy M, Mathews E, Brande W, Rickles FR: Activation of blood coagulation in Crohn's disease. Increased plasma fibrinopepsitide A levels and enhanced generation of monocytes tissue factor activity. Gastroenterology 92:329-337, 1987.
28. Miller CL, Graziano C, Lim RC, Chin M: Generation of tissue factor by patients monocytes. Correlation to thromboembolic complications. Throm Haemost 489-493, 1981.
29. Hogg N: Human monocytes are associated with the formation of fibrin. 157:473-485, 1983.
30. Muller-Berghaus G, Bohn E, Hobel W: Activation of intra-vascular coagulation by endotoxin: The significance of granulocytes and platelets. Br J Haematol 33:213-220, 1976.
31. Viero P, Cortellazza S, Casarotto C, Barbini T, Colueci M, Semeraro N: Increased production of mononuclear cell procoagulant activity in Hodgkin's disease. Eur J Cancer Clin Oncol 19:1539-1543, 1983.
32. Oian P, Omsjo I, Martin Maltan J, Osternd B: Increased sensitivity to thromboplastin synthesis in blood monocytes from pre-eclamptic patients. J Obstet Gynecol 92:511-517, 1985.
33. Cohen AM, Gelran A, Kadouri A, Creter D, Djaldetti M: Tissue plasminogen activator levels in different types of polycythemia. Eur J Haematol 45:48-51, 1980.
34. Finelli C, Palareti G, Poggi M, Torricelli P, Vianelli M, Fiacchini M, Zuffa E, Ricci P, Gugliotta L, Coccheri S, Tura S: Ticlopidine lowers plasma fibrinogen in patients with polycythaemia rubra vera and additional thrombotic risk factors. Acta Haematol 85:113-118, 1991.
35. Pinder PB, Hunt JA, Zacharski LR: In vitro stimulation of monocyte tissue factor activity by autologous platelets. Am J Hematol 19:317-325, 1985.
36. Edwards RL, Rickles FR, Bobrove AM: Mononuclear cell tissue factor. Cell of origin and requirements for activation. Blood 54:359-370, 1979.
37. Kornberg A, Fibach E, Treves A, Rachmilewitz EA: Circulating erythroid progenitors in patients with spent polycythaemia vera and myelofibrosis with myeloid metaplasia. Br J Haematol 52:573-578, 1982.