Effect of acute and chronic tramadol on [3H]-5-HT uptake in rat cortical synaptosomes

British Journal of Pharmacology

Volumn 122, Issue 2, 1997, Pages 302-306

  Giusti, Pietro ^a,b   Buriani, Alessandro ^a   Cima, Lorenzo ^a   Lipartiti, Maria ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Department of Pharmacology ^*  (Italy)

Author keywords

3H 5 HT uptake; Antinociception; Methadone; Morphine; Pain; Tramadol

Indexed keywords

DESIPRAMINE; FLUOXETINE; METHADONE; MORPHINE; NARCOTIC ANALGESIC AGENT; SEROTONIN; TRAMADOL;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; HOT PLATE TEST; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN UPTAKE;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; MALE; METHADONE; MORPHINE; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SYNAPTOSOMES; TRAMADOL;

EID: 0030882359     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701374     Document Type: Article

References (25)

1. BARTH, H., DURRA, S., GIERTZ, H., GOROLL, A. & FLOHE, L. (1987). Long-term administration of the centrally acting analgesic tramadol did not induce dependence and tolerance. Pain, 4, S231.
2. CODD, E.E., SHANK, R.P., SCHUPSKY, J.J. & RAFFA, R.B. (1995). Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J. Pharmacol. Exp. Ther., 274, 1263-1270.
3. COLLART, L., LUTHY, C. & DAYER, P. (1993). Partial inhibition of tramadol antinociceptive effect by naloxone in man. Br. J. Clin. Pharmacol., 35, 73P.
4. DRIESSEN, B. & REIMANN, W. (1992). Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. Br. J. Pharmacol., 105, 147-151.
5. EDDY, N.B. & LEINBACH, D. (1953). Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J. Pharmacol. Exp. Ther., 107, 385-393.
6. FINNEY, D.J. (1971). Probit Analysis, 3rd Edition. Cambridge: Cambridge University Press.
7. FRINK, M.C., HENNIES, H.H., ENGLBERGER, W., HAURAND, M. & WILFFERT, B. (1996). Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung/Drug Res., 46, 1029-1036.
8. HENNIES, H.H., FRIDERICHS, E. & SCHNEIDER, J. (1988). Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittelforschung/Drug Res., 38, 877-880.
9. HUBER, H.P. (1978). Examination of psychic effects of a new analgesic agent of the cyclohexanols series. A contribution to a possible psychic dependence potential of tramadol. Arzmeimittelforschung, 28, 189-191.
10. KAYSER, V., BESSON, J.-M. & GUIBAUD, G. (1991). Effects of analgesic agent tramadol in normal and arthritic rats: comparison with the effects of different opioids, including tolerance and cross-tolerance to morphine. Eur. J. Pharmacol., 195, 37-45.
11. KELLER, E.A., CANCELA, L.M., MOLINA, V.A. & ORSINGHER, O.R. (1994). Lack of adaptative changes in 5-HT sites in perinatally undernourished rats after chronic stress: opioid influence. Pharmacol. Biochem. Behav., 47, 789-793.
12. LAGLER, F., HELM, F., ETZEL, V. & KIEL, H. (1978). Toxikologische Untersuchungen mit tramadol, einem neuen analgetikum. Arzneimittelforschung/Drug Res., 28, 164-172.
13. LEE, C.R., MC TAVISH, D. & SORKIN, E.M. (1993). Tramadol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutical potential in acute and chronic pain states. Drugs, 46, 313-340.
14. LEHMANN, K.A., KRATZENBERG, U., SCHROEDER-BARK, B. & HORRICHS-HAERMEYER, G. (1990). Post-operative patient-controlled analgesia with tramadol: analgesia efficacy and minimum effective concentrations. Clin. J. Pain, 6, 212-220.
15. LOWRY, O.H., ROSEBROUGH, N.H., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
16. MAGNI, G. (1991). The use of antidepressants in the treatment of chronic pain. Drugs, 42, 730-748.
17. MAX, M.B., LYNCH, S.A., MUIR, J., SHOAF, S.E., SMOLLER, B. & DUBNER, R. (1992). Effects of desimipramine, amitriptyline and fluoxetine on pain in diabetic neuropathy. N. Engl. J. Med., 326, 1250-1256.
18. MCPHERSON, G.I. (1987). Ligand (Release 2.0). Cambridge: Elsevier Biosoft.
19. 3H]-5-hydroxytryptamine in rat hypothalamus slices. Eur. J. Pharmacol., 35, 289-297.
20. PRESTON, K.L., JASINSKI, D.R. & TESTA, M. (1991). Abuse potential and pharmacological comparison between tramadol and morphine. Drug Alcohol Depend., 27, 7-17.
21. RAFFA, R.B., FRIDERICHS, E., REIMANN, W., SHANK, R.P., CODD, E.E. & VAUGHT, J.L. (1992). Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J. Pharmacol. Exp. Ther., 260, 275-285.
22. SHARAV, Y., SINGER, E., SCHMIDT, E., DIONNE, R.A. & DUBNER, R. (1987). The analgesic effect of amitriptyline on chronic facial pain. Pain, 31, 199-209.
23. VENTAFRIDDA, V., CARACENI, A., SAUTA, L., BONEZZI, C., DE CONNO, F., GUARISE, G., RAMELLA, G., SILVANI, V., TAMBURINI, M. & TOSCANI, F. (1988). Trazodone for deafferentation pain. Comparison with amitriptyline. Psychopharmacology, 95, S44-S49.
24. WHITTAKER, V.P. & BARKER, L.A. (1972). The subcellular fractionation of brain tissue with special reference to the preparation of synaptosomes and their component organelles. In Methods in Neurochemistry, Vol. 2. ed. Fried, R. pp. 1-52. New York: Marcel Dakker, Inc.
25. YASK, T.L. (1985). Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol. Biochem. Behav., 22, 845-858.