Glutamate excitation of oxytocin neurones in vitro involves predominantly non-NMDA receptors

Brain Research

Volumn 767, Issue 1, 1997, Pages 158-161

  Richardson, C M ^a   Wakerley, J B ^a  

^a Dept Anat Sch Med Sci U   (United Kingdom)

Author keywords

AMPA; Glutamate receptor; NMDA; Oxytocin neuron; Supraoptic nucleus; Vasopressin neuron

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMIC ACID; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXYTOCIN; VASOPRESSIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; NERVE CELL EXCITABILITY; NEUROTRANSMITTER RELEASE; NONHUMAN; OXYTOCIN RELEASE; PRIORITY JOURNAL; RAT; SUPRAOPTIC NUCLEUS; SYNAPSE;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; ENKEPHALIN, LEUCINE-2-ALANINE; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLUTAMIC ACID; NEURONS; OXYTOCIN; QUINOXALINES; RATS; RATS, WISTAR;

EID: 0030882273     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00728-2     Document Type: Article

References (20)

1. Armstrong W.E. Morphological and electrophysiological classification of hypothalamic supraoptic neurons. Prog. Neurobiol. 47:1995;291-339.
2. Ginsberg S.D., Price D.L., Blackstone C.D., Huganir R.L., Martin L.J. The AMPA glutamate receptor GluR3 is enriched in oxytocinergic magnocellular neurons and is located at synapses. Neuroscience. 65:1995;563-575.
3. Gribkoff V.K. Electrophysiological evidence for N-methyl-D-aspartate excitatory amino acid receptors in the rat supraoptic nucleus in vitro. Neurosci. Lett. 131:1991;260-262.
4. Haller E.W., Wakerley J.B. Electrophysiological studies of paraventricular and supraoptic neurones recorded in vitro from slices of rat hypothalamus. J. Physiol. 302:1980;347-362.
5. Hu B., Bourque C.W. Functional N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors are expressed by rat supraoptic neurosecretory cells in vitro. J. Neuroendocrinol. 3:1991;509-514.
6. Hu B., Bourque C.W. NMDA receptor-mediated rhythmic bursting activity in rat supraoptic nucleus neurones in vitro. J. Physiol. 458:1992;667-687.
7. Lincoln D.W., Wakerley J.B. Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin. J. Physiol. 242:1974;533-554.
8. Meeker R.B., Swanson D.J., Greenwood R.S., Hayward J.N. Quantitative mapping of glutamate presynaptic terminals in the supraoptic nucleus and surrounding hypothalamus. Brain Res. 600:1993;112-122.
9. F.C. Moos, K. Rossi, Ph. Richard, Activation of N-methyl-D-aspartate receptors regulates basal electrical activity of oxytocin and vasopressin neurons in lactating rats, Neuroscience (1997) in press.
10. Nissen R., Hu B., Renaud L.P. N-Methyl-D-aspartate receptor antagonist ketamine selectively attenuates spontaneous phasic activity of supraoptic vasopressin neurons in vivo. Neuroscience. 59:1994;115-120.
11. Nissen R., Hu B., Renaud L.P. Regulation of spontaneous phasic firing of rat supraoptic vasopressin neurones in vivo by glutamate receptors. J. Physiol. 484:1995;415-424.
12. Nowak L., Bregestovski P., Ascher P., Herbert A., Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature. 307:1984;462-465.
13. Palkovits M., Lang T., Patthy A., Elekes I. Distribution and stress-induced increase in glutamate and aspartate levels in discrete brain nuclei of rats. Brain Res. 373:1986;252-257.
14. Parker S.L., Crowley W.R. Stimulation of oxytocin release in the lactating rat by central excitatory amino acid mechanisms: evidence for specific involvement of R,S-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-sensitive glutamate receptors. Endocrinology. 133:1993;2847-2854.
15. Smith S.S. Female sex steroid hormones: from receptors to networks to performance - actions on the sensorimotor system. Prog. Neurobiol. 44:1994;55-86.
16. van den Pol A.N., Hermans-Borgmeyer I., Hofer M., Ghosh P., Heinemann S. Ionotropic glutamate-receptor gene expression in hypothalamus: localization of AMPA, kainate, and NMDA receptor RNA with in situ hybridization. J. Comp. Neurol. 343:1994;428-444.
17. van den Pol A.N., Wuarin J.P., Dudek F.E. Glutamate, the dominant excitatory transmitter in neuroendocrine regulation. Science. 250:1990;1276-1277.
18. Wakerley J.B., Nobel R., Clark G. Effects of morphine and D-Ala,D-Leu enkephalin on the electrical activity of supraoptic neurosecretory cells in vitro. Neuroscience. 10:1983;73-81.
19. Wong M., Moss R.L. Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels. J. Neuroendocrinol. 6:1994;347-355.
20. Yang Q.Z., Smithson K.G., Hatton G.I. NMDA and non-NMDA receptors on rat supraoptic nucleus neurons activated monosynaptically by olfactory afferents. Brain Res. 680:1995;207-216.