Effects of iontophoretic current flow on hairless rat skin in vivo

Journal of Controlled Release

Volumn 49, Issue 1, 1997, Pages 89-94

  Fouchard, Delphine ^a   Hueber, Frédérique ^b   Teillaud, Eric ^b   Marty, Jean Paul ^a  

^a Res U Dermopharmacology C   (France)

^b Laboratoires Fournier Tilderm S   (France)

Author keywords

Hairless rat; Iiontophoresis; In vivo; Non invasive methodologies; Skin tolerance

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLORIMETRY; DIRECT CURRENT; ELECTRIC CURRENT; ERYTHEMA; HYDRATION; IONTOPHORESIS; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SKIN SURFACE; SKIN WATER LOSS; TECHNIQUE;

EID: 0030882166     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00077-1     Document Type: Article

References (14)

1. P.G. Green, M. Flanagan, B.Shroot, R.H. Guy, Iontophoretic drug delivery, in: K.A. Walters, J. Hadgraft (Eds.), Pharmaceutical Skin Penetration Enhancement. Marcel Dekker, New York, 1993, pp. 311-333.
2. Pikal H.J. Transport mechanisms in iontophoresis. I. A theoretical model for the effect of electroosmotic on flux enhancement in transdermal iontophoresis. Pharm. Res. 7(2):1990;118-126.
3. Pikal H.J., Shah S. Transport mechanisms in iontophoresis. III. An experimental study of the contributions of electroosmotic flow and permeability change in transport of low and high molecular weight solutes. Pharm. Res. 7(3):1990;222-229.
4. Diffey B.L., Olivier R.J., Farr P.M. A portable instrument for quantifying erythema induced by ultraviolet radiation. Br. J. Dermatol. 3:1984;663-672.
5. Gicquel M., Millot P., Hueber F., Teillaud E. Human skin tolerance study of 4 different iontophoretic currents: Effects of waveforms and frequency. Proc. Int. Symp. Rel. Bioact. Mater. 21:1994;363-364.
6. Van der Geest R., Elshove D.A.R., Lavrijsen A.P.M., Boddé H.E. Non-invasive assessment of skin barrier integrity and skin irritation following iontophoretic current application in humans. Proc. Int. Symp. Rel. Bioact. Mater. 21:1994;726-727.
7. V. Préat, S. Thysman, D. Van Neste, Evaluation of human skin after iontophoresis with non invasive methods, in: K.R. Brain, V.J. James, K.A. Walters (Eds.), Prediction of percutaneous penetration, Vol 3b. 1993, pp. 406-409.
8. Singh J., Gross M., O'Connell M., Sage B., Maibach H.I. Effect of skin preparation and iontophoresis on skin functions and irritation in human volunteers. Pharm. Res. 11:1994;S-101.
9. Thysman S., Van Neste D., Préat V. Non invasive investigation of human skin after in vivo iontophoresis. Skin Pharmacol. 8:1995;229-236.
10. Green P., Shroot B., Bernerd F., Pilgrim W.R., Guy R.H. In vitro and in vivo iontophoresis of a tripeptide across nude rat skin. J. Control. Release. 20:1992;209-218.
11. Monteiro-Rivière N.A. Altered epidermal morphology secondary to lidocaine iontophoresis: in vivo and in vitro studies in porcine skin. Fund. Appl. Toxicol. 15:1990;174-185.
12. Ledger P.W. Skin biological issues in electrically enhanced transdermal delivery. Adv. Drug Deliv. Rev. 9:1992;289-307.
13. R.D. Green, J. Hadgraft, FTIR investigations into the effect of iontophoresis on the skin, in: K.R. Brain, V.J. James, K.A. Walters (Eds.), Prediction of percutaneous penetration, Vol 3b. 1993, pp. 37-43.
14. Clancy M.J., Corish J., Corrigan O.I. A comparison of the effects of electrical current and penetration enhancers on the properties of human skin using spectroscopic (FTIR) and calorimetric (DSC) methods. Int. J. Pharm. 105:1994;47-56.