Gene transfer using a novel fusion protein, GAL4/Invasin

Human Gene Therapy

Volumn 8, Issue 10, 1997, Pages 1253-1262

  Paul, Ralph W ^a   Weisser, Karen E ^a   Loomis, Aaron ^a   Sloane, David L ^a   LaFoe, Dan ^a   Atkinson, E Morrey ^a   Overell, Robert W ^a  

^a Targeted Genetics Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; DNA BINDING PROTEIN; HYBRID PROTEIN; INVASIN; POLYLYSINE; TRANSCRIPTION FACTOR;

ARTICLE; CONSENSUS SEQUENCE; ESCHERICHIA COLI; GENE TARGETING; GENE TRANSFER; MOLECULAR RECOGNITION; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEIN PURIFICATION; YERSINIA PSEUDOTUBERCULOSIS;

ESCHERICHIA COLI; FELIS CATUS; YERSINIA PSEUDOTUBERCULOSIS;

EID: 0030881509     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.10-1253     Document Type: Article

References (51)

1. ALI, M., LEMOINE, N.R., and RING, C.J.A. (1994). The use of DNA viruses as vectors for gene therapy. Gene. Ther. 1, 367-384.
2. 1 integrins. Eur. J. Immunol. 23, 1608-1614.
3. BERGELSON, J.M., SHEPLEY, M.P., CHAN, B.M.C., HEMLER, M.E., and FINBERG, R.W. (1992). Identification of the integrin VLA-2 as a receptor for echovirus 1. Science 255, 1718-1720.
4. 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells. J. Virol. 69, 2664-2666.
5. BUCK, C.A., and HORWITZ, A.F. (1987). Cell surface receptors for extracellular matrix molecules. Annu. Rev. Cell Biol. 3, 179-205.
6. CAREY, M., KAKIDANI, H., LEATHERWOOD, J., MOSTASHARI, F., and PTASHNE, M. (1989). An amino-terminal fragment of GAL4 binds DNA as a dimer. J. Mol. Biol. 209, 423-432.
7. CHASMAN, D.I., LEATHERWOOD, J.A., CAREY, M., PTASHNE, M., and KORNBERG, R.D. (1989). Activation of yeast polymerase II transcription by Herpesvirus VP16 and GAL4 derivatives in vitro. Mol. Cell. Biol. 9, 4746-4749.
8. CURIEL, D.T., AGARWAL, S., WAGNER, E., and COTTEN, M. (1991). Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. USA 88, 8850-8854.
9. CURTIS, B.M., WILLIAMS, D.E., BROXMEYER, H.E., DUNN, J., FARRAH, T., JEFFERY, E., CLEVENGER, W., DEROOS, P., MARTIN, U., FRIEND, D., CRAIG, V., GAYLE, R., PRICE, V., COSMAN, D., MARCH, C.J., and PARKS, L.S. (1991). Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein. Proc. Natl. Acad. Sci. USA 88, 5809-5813.
10. 1 integrin ligand invasin. J. Exp. Med. 177, 207-212.
11. FELGNER, P.L., TSAI, Y.J., SUKHU, L., WHEELER, C.J., MANTHROPE, M., MARSHALL, J., and CHENG, S.H. (1995). Improved cationic lipid formulations for in vivo gene therapy. Ann. NY Acad. Sci. 772, 126-139.
12. FLOTTE, T.R., and CARTER, B.J. (1995). Adeno-associated virus vectors for gene therapy. Gene Ther. 2, 357-362.
13. FOMINAYA, J., and WELS, W. (1996). Target cell-specific DNA transfer mediated by a chimeric multidomain protein. J. Biol. Chem. 271, 10560-10568.
14. FRANCIS, C.L., STARNBACH, M.M., and FALKOW, S. (1992). Morphological and cytoskeletal changes in epithelial cells occur immediately upon interaction with Salmonella typhimurium grown under low-oxygen conditions. Mol. Microl. 6, 3077-3078.
15. FRITZ, J.D., HERWEIJER, H., ZHANG, G., and WOLFF, J.A. (1996). Gene transfer into mammalian cells using histone-condensed plasmid DNA. Hum. Gene Ther. 7, 1395-1404.
16. GAO, X., and HUANG, L. (1996). Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry 35, 1027-1036.
17. GINIGER, E., VARNUM, S.M., and PTASHNE, M. (1985). Specific DNA binding of GAL4, a positive regulatory protein of yeast. Cell 40, 767-774.
18. GORMAN, C.M., MOFFAT, L.F., and HOWARD, B.H. (1982). Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
19. GOTTSCHALK, S., SPARROW, J.T., HAUER, J., MIMS, M.P., LELAND, F.E., WOO, S.L.C., and SMITH, L.C. (1996). A novel DNA-peptide complex for efficient gene transfer and expression in mammalian cells. Gene Ther. 3, 448-457.
20. HAENSLER, J., and SZOKA, F.C. JR. (1993). Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconj. Chem. 4, 372-379.
21. HART, S.L., HARBOTTLE, R.P., COPPER, R., MILLER, A., WILLIAMSON, R., and COUTELLE, C. (1996). Gene delivery and expression mediated by an integrin binding peptide. Gene Ther. 2, 552-554.
22. HEMLER, M.E. (1990). VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8, 365-400.
23. ISBERG, R.R., and FALKOW, S. (1985). A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12. Nature 317, 262-264.
24. ISBERG, R.R., and LEONG, J.M. (1990). Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell 60, 861-871.
25. ISBERG, R.R., VOORHIS, D.L., and FALKOW, S. (1987). Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell 50, 769-778.
26. JOLLY, D. (1994). Viral vector systems for gene therapy. Cancer Gene Ther. 1, 51-64.
27. LAUGHON, A., and GESTELAND, R.F. (1984). Primary structure of the Saccharomyces cerevisiae GAL4 gene. Mol. Cell. Biol. 4, 260-267.
28. LEONG, J.M., FOURNIER, R.S., and ISBERG, R.R. (1990). Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. EMBO J. 9, 1979-1989.
29. MELLMAN, L., FUCHS, R., and HELENIUS, A. (1986). Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem. 55, 663-700.
30. MOSLEY, B., BACKMANN, P.M., MARCH, C.J., IDZERDA, R.L., GIMPEL, S.D., VANDENBOS, T., FRIEND, D., ALPERT, A., ANDERSON, D., JACKSON, J., WIGNALL, J.M., SMITH, C., GALLIS, B., SIMS, J.E., URDAL, D., WIDMER, M.B., COSMAN, D., and PARK, L.S. (1989). The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 59, 335-348.
31. PLANK, C., MECHTLER, K., SZOKA, F.C.JR., and WAGNER, E. (1996). Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum. Gene Ther. 7, 1437-1446.
32. PYTELA, R., PIERSCHBACHER, M.D., and ROUSLAHTI, E. (1985). Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell 40, 191-198.
33. RANKIN, S., ISBERG, R.R., and LEONG, J.M. (1992). The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells. Infect. Immun. 60, 3909-3912.
34. RANKIN, S., TRAN VAN NHIEU, G., and ISBERG, R.R. (1994). Use of staphylococcus aureus coated with invasin derivatives to assay invasin function. Methods Enzymol 236, 566-577.
35. REECE, R.J., RICKLES, R.R., and PTASHNE, M. (1993). Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli. Gene 126, 105-107.
36. ROSENSHINE, I., DURUNIO, V., and FINLAY. (1992). Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells. Infect. Immun. 60, 2211-2217.
37. SANGER, F., NICKLEN, S., and COULSON, A.R. (1977). DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci., USA 74, 5463-5467.
38. SCHMITZ, M.L., and BAEUERLE, P.A., (1994). A vector, pHisGal allowing bacterial production of proteins fused to a hexahistidine tagged GAL4 DNA-binding domain. BioTechniques 17, 714-717.
39. 1 integrins during human melanoma cell invasion. Cancer Res. 53, 3411-3415.
40. SILVER, P.A., KEEGAN, L.P., and PTASHNE, M. (1984). Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proc. Natl. Acad. Sci. USA 81, 5951-5955.
41. SOSNOWSKI, B.A., GONZALEZ, A.M., CHANDLER, L.A., BUECHLER, Y.J., PIERCE, G.F., and BAIRD, A. (1996). Targeting DNA to cells with basic fibroblast growth factor (FGF2). J. Biol. Chem. 271, 33647-33653.
42. 1 integrin receptor. J. Biol. Chem. 266, 24367-24375.
43. TRAN VAN NHIEU, G., and ISBERG, R.R. (1993). Bacterial internalization mediated by β1 integrins is determined by ligand affinity and receptor density. EMBO J. 12, 1887-1895.
44. 6" proteins distinguish between similar upstream activation sites? J. Biol. Chem. 268, 24699-24706.
45. VERDAGUER, N., MATEU, M.G., ANDREU, D., GIRALT, E., DOMINGO, E., and FITA I. (1995). Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: Direct involvement of the Arg-Gly-Asp motif in the interaction. EMBO J. 14, 1690-1696.
46. VITIELLO, L., CHONN, A., WASSERMAN, J.D., DUFF, C., and WORTON, R.G. (1996). Condensation of plasmid DNA with polylysine improves liposome-mediated gene transfer into established and primary muscle cells. Gene Ther. 3, 396-404.
47. WAGNER, E., COTTEN, M., MECHTLER, K., KIRLAPPOS, H., and BIRNSTIEL, M.L. (1991). DNA-binding transferrin conjugates as functional gene-delivery agents-Synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety. Bioconj. Chem. 2, 226-131.
48. 5 promote adenovirus internalization, but not virus attachment. Cell 73, 309-319.
49. WOLFF, J.A., MALONE, R.W., WILLIAMS, P., CHONG, W., ACSADI, G., JANI, A., and FELGNER, P.L. (1990). Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468.
50. YANG, J-P., and HUANG, L. (1996). Direct gene transfer to mouse melanoma by intratumoral injection of free DNA. Gene Ther. 3, 542-548.
51. YANG, N.-S., BURHOLDER, J.K., ROBERTS, B., MARTINELL, B., and McCABE, D. (1990). In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc. Natl. Acad. Sci. USA 87, 9568-9572.