메뉴 건너뛰기




Volumn 74, Issue 3, 1997, Pages 317-332

Oligonucleotides as modulators of cancer gene expression

Author keywords

Antisense; Cancer; Oligonucleotide; Review; Ribozyme; Triplex

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; OLIGONUCLEOTIDE; PEPTIDE NUCLEIC ACID; PLATELET DERIVED GROWTH FACTOR B; PLEIOTROPHIN; RIBOZYME;

EID: 0030881290     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(97)00005-3     Document Type: Review
Times cited : (35)

References (157)
  • 1
    • 0022972284 scopus 로고
    • Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribonucleoside methylphosphonates
    • Agris, C. H., Blake, K. R., Miller, P. S., Reddy, M. P. and Ts'o, P. O. P. (1986) Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribonucleoside methylphosphonates. Biochemistry 25: 6268-6275.
    • (1986) Biochemistry , vol.25 , pp. 6268-6275
    • Agris, C.H.1    Blake, K.R.2    Miller, P.S.3    Reddy, M.P.4    Ts'o, P.O.P.5
  • 2
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N. and Perucho, M. (1988) Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53: 549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 3
    • 0024233053 scopus 로고
    • An unwinding activity that covalently modifies its double-stranded RNA substrate
    • Bass, B. L. and Weintraub, H. (1988) An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell 31: 1089-1098.
    • (1988) Cell , vol.31 , pp. 1089-1098
    • Bass, B.L.1    Weintraub, H.2
  • 4
    • 0028275081 scopus 로고
    • Can hammerhead ribozymes be efficient tools to inactivate gene function?
    • Bertrand, E., Pictet, R. and Grange, T. (1994) Can hammerhead ribozymes be efficient tools to inactivate gene function? Nucl. Acids Res. 22: 293-300.
    • (1994) Nucl. Acids Res. , vol.22 , pp. 293-300
    • Bertrand, E.1    Pictet, R.2    Grange, T.3
  • 5
    • 0026083388 scopus 로고
    • Inhibition of translation by antisense oligonucleotides via an RNase-H independent mechanism
    • Boiziau, C., Kufurst, R., Cazenave, C., Roig, V., Thuong, N. T. and Toulme, J.-J. (1991) Inhibition of translation by antisense oligonucleotides via an RNase-H independent mechanism. Nucl. Acids Res. 19: 1113-1119.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 1113-1119
    • Boiziau, C.1    Kufurst, R.2    Cazenave, C.3    Roig, V.4    Thuong, N.T.5    Toulme, J.-J.6
  • 6
    • 0024376173 scopus 로고
    • ras Oncogene in human cancer: A review
    • Bos, J. L. (1989) ras Oncogene in human cancer: a review. Cancer Res. 49: 4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 10
    • 0019856947 scopus 로고
    • In vitro splicing of the ribosomal RNA precursor of Tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence
    • Cech, T. R., Zaug, A. J. and Grabowski, P. J. (1981) In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell 27: 487-496.
    • (1981) Cell , vol.27 , pp. 487-496
    • Cech, T.R.1    Zaug, A.J.2    Grabowski, P.J.3
  • 12
    • 0026651984 scopus 로고
    • Inhibition of leukemic cell proliferation by receptor-mediated uptake of c-myb antisense oligonucleotides
    • Citro, G., Perotti, D., Cuci, C., D'Agnano, I., Sacchi, A., Zupi, G. and Calabretta, B. (1992) Inhibition of leukemic cell proliferation by receptor-mediated uptake of c-myb antisense oligonucleotides. Proc. Natl. Acad. Sci. USA 89: 7031-7035.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7031-7035
    • Citro, G.1    Perotti, D.2    Cuci, C.3    D'Agnano, I.4    Sacchi, A.5    Zupi, G.6    Calabretta, B.7
  • 13
    • 0023802737 scopus 로고
    • Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro
    • Cooney, M., Czernuszewicz, G., Postel, E. H., Flint, S. J. and Hogan, M. E. (1988) Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro. Science 241: 456-459.
    • (1988) Science , vol.241 , pp. 456-459
    • Cooney, M.1    Czernuszewicz, G.2    Postel, E.H.3    Flint, S.J.4    Hogan, M.E.5
  • 14
    • 0026356572 scopus 로고
    • In vitro toxicology and pharmacokinetics of antisense oligonucleotides
    • Crooke, R. M. (1991) In vitro toxicology and pharmacokinetics of antisense oligonucleotides. Anticancer Drug Des. 6: 609-646.
    • (1991) Anticancer Drug Des. , vol.6 , pp. 609-646
    • Crooke, R.M.1
  • 15
    • 0026721173 scopus 로고
    • Therapeutic applications of oligonucleotides
    • Crooke, S. T. (1992) Therapeutic applications of oligonucleotides. Annu. Rev. Pharmacol. Toxicol. 32: 329-376.
    • (1992) Annu. Rev. Pharmacol. Toxicol. , vol.32 , pp. 329-376
    • Crooke, S.T.1
  • 16
    • 0027481659 scopus 로고
    • Progress toward oligonucleotide therapeutics: Pharmacodynamic properties
    • Crooke, S. T. (1993) Progress toward oligonucleotide therapeutics: pharmacodynamic properties. FASEB J. 7: 533-539.
    • (1993) FASEB J. , vol.7 , pp. 533-539
    • Crooke, S.T.1
  • 17
    • 0028146336 scopus 로고
    • Ribozyme-targeting elucidates a direct role of pleiotropin in tumor growth
    • Czubayko, F., Riegel, A. T. and Wellstein, A. (1994) Ribozyme-targeting elucidates a direct role of pleiotropin in tumor growth. J. Biol. Chem. 269: 21358-21363.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21358-21363
    • Czubayko, F.1    Riegel, A.T.2    Wellstein, A.3
  • 18
    • 0027256844 scopus 로고
    • Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1
    • Demidov, V., Frank-Kamentskii, M. D., Egholm, M., Buchardt, O. and Nielson, P. E. (1993) Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1. Nucl. Acids Res. 21: 2103-2107.
    • (1993) Nucl. Acids Res. , vol.21 , pp. 2103-2107
    • Demidov, V.1    Frank-Kamentskii, M.D.2    Egholm, M.3    Buchardt, O.4    Nielson, P.E.5
  • 19
    • 0028136160 scopus 로고
    • Modulation of platelet-derived growth factor-beta mRNA expression and cell growth in a human mesothelioma cell line by a hammerhead ribozyme
    • Dorai, T., Kobayashi, H., Holland, J. F. and Ohnuma, T. (1994) Modulation of platelet-derived growth factor-beta mRNA expression and cell growth in a human mesothelioma cell line by a hammerhead ribozyme. Mol. Pharmacol. 46: 437-444.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 437-444
    • Dorai, T.1    Kobayashi, H.2    Holland, J.F.3    Ohnuma, T.4
  • 21
    • 0027422247 scopus 로고
    • The pathway to signal achievement
    • Egan, S. E. and Weinberg, R. A. (1993) The pathway to signal achievement. Nature 365: 781-783.
    • (1993) Nature , vol.365 , pp. 781-783
    • Egan, S.E.1    Weinberg, R.A.2
  • 22
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoprotein mediated multidrug resistance
    • Endicott, J. A. and Ling, V. (1989) The biochemistry of P-glycoprotein mediated multidrug resistance. Annu. Rev. Biochem. 58:131-171.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 131-171
    • Endicott, J.A.1    Ling, V.2
  • 23
    • 0024464361 scopus 로고
    • Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA
    • Feldstein, P. A., Buzayan, J. M. and Bruening, G. (1989) Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA. Gene 82: 53-61.
    • (1989) Gene , vol.82 , pp. 53-61
    • Feldstein, P.A.1    Buzayan, J.M.2    Bruening, G.3
  • 24
    • 0000842047 scopus 로고
    • Studies on the formation of two- and three-stranded polyribonucleotides
    • Felsenfeld, G. and Rich, A. (1957) Studies on the formation of two- and three-stranded polyribonucleotides. Biochem. Biophys. Acta 26: 457-468.
    • (1957) Biochem. Biophys. Acta , vol.26 , pp. 457-468
    • Felsenfeld, G.1    Rich, A.2
  • 25
    • 33947470407 scopus 로고
    • Formation of a three-stranded polynucleotide molecule
    • Felsenfeld, G., Davies, D. R. and Rich, A. (1957) Formation of a three-stranded polynucleotide molecule. J. Am. Chem. Soc. 79: 2023-2024.
    • (1957) J. Am. Chem. Soc. , vol.79 , pp. 2023-2024
    • Felsenfeld, G.1    Davies, D.R.2    Rich, A.3
  • 26
    • 0029069106 scopus 로고
    • Neoplastic reversion accomplished by high efficiency adenoviral mediated delivery of anti-ras ribozymes
    • Feng, M., Cabrera, G., Deshane, J., Scanlon, K. J. and Curiel, D. T. (1995) Neoplastic reversion accomplished by high efficiency adenoviral mediated delivery of anti-ras ribozymes. Cancer Res. 55: 2024-2028.
    • (1995) Cancer Res. , vol.55 , pp. 2024-2028
    • Feng, M.1    Cabrera, G.2    Deshane, J.3    Scanlon, K.J.4    Curiel, D.T.5
  • 28
    • 0027714411 scopus 로고
    • Pharmacologic circumvention of multidrug resistance
    • Ford, J. M. and Hait, W. N. (1993) Pharmacologic circumvention of multidrug resistance. Cytotechnology 12: 171-212.
    • (1993) Cytotechnology , vol.12 , pp. 171-212
    • Ford, J.M.1    Hait, W.N.2
  • 29
    • 0011086492 scopus 로고
    • Sequence-specific recognition of duplex DNA via triple-helix formation for oligonucleotides covalently linked to a phenanthroline-copper chelate
    • Francois, J.-C., Saison-Behmoaras, T., Barbier, C., Chassignal, M., Thuong, N. T. and Hélène, C. (1989) Sequence-specific recognition of duplex DNA via triple-helix formation for oligonucleotides covalently linked to a phenanthroline-copper chelate. Proc. Natl. Acad. Sci. USA 87: 9858-9862.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9858-9862
    • Francois, J.-C.1    Saison-Behmoaras, T.2    Barbier, C.3    Chassignal, M.4    Thuong, N.T.5    Hélène, C.6
  • 32
    • 0026770099 scopus 로고
    • Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter
    • Gee, J. E, Blume, S., Snyder, R. C., Ray, R. and Miller, D. M. (1992) Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter. J. Biol. Chem. 267: 11163-11167.
    • (1992) J. Biol. Chem. , vol.267 , pp. 11163-11167
    • Gee, J.E.1    Blume, S.2    Snyder, R.C.3    Ray, R.4    Miller, D.M.5
  • 33
    • 0027175360 scopus 로고
    • Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct
    • Georges, R. N., Mukhopadhyay, T., Zhang, Y., Yen, N. and Roth, J. A. (1993) Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct. Cancer Res. 53: 1743-1746.
    • (1993) Cancer Res. , vol.53 , pp. 1743-1746
    • Georges, R.N.1    Mukhopadhyay, T.2    Zhang, Y.3    Yen, N.4    Roth, J.A.5
  • 34
    • 0024270537 scopus 로고
    • A c-myb antisense oligonucleotide inhibits normal human hematopoiesis in vitro
    • Gewirtz, A. M. and Calabretta, B. (1988) A c-myb antisense oligonucleotide inhibits normal human hematopoiesis in vitro. Science 242: 1303-1306.
    • (1988) Science , vol.242 , pp. 1303-1306
    • Gewirtz, A.M.1    Calabretta, B.2
  • 36
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman, M. M. and Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62: 385-427.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 37
    • 0022515908 scopus 로고
    • Isolation and characterization of DNA sequences amplified in multidrug resistant hamster cells
    • Gros, P., Croop, J., Roninson, I., Varshavsky, A. and Housman, D. E. (1986) Isolation and characterization of DNA sequences amplified in multidrug resistant hamster cells. Proc. Natl. Acad. Sci. USA 83: 337-341.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 337-341
    • Gros, P.1    Croop, J.2    Roninson, I.3    Varshavsky, A.4    Housman, D.E.5
  • 39
    • 0021013526 scopus 로고
    • The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
    • Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N. and Altman, S. (1983) The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme. Cell 35: 849-857.
    • (1983) Cell , vol.35 , pp. 849-857
    • Guerrier-Takada, C.1    Gardiner, K.2    Marsh, T.3    Pace, N.4    Altman, S.5
  • 40
    • 0000046089 scopus 로고
    • A human beta-actin expression vector system directs high-level accumulation of antisense transcripts
    • Gunning, P., Leavitt, J., Muscat, G., Ng, S. and Kedes, L. (1987) A human beta-actin expression vector system directs high-level accumulation of antisense transcripts. Proc. Natl. Acad. Sci. USA 84: 4831-4835.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 4831-4835
    • Gunning, P.1    Leavitt, J.2    Muscat, G.3    Ng, S.4    Kedes, L.5
  • 41
    • 0024340908 scopus 로고
    • RNA catalytic properties of the minimum (-)sTRSV sequence
    • Hampel, A. and Tritz, R. (1989) RNA catalytic properties of the minimum (-)sTRSV sequence. Biochemistry 28: 4929-4933.
    • (1989) Biochemistry , vol.28 , pp. 4929-4933
    • Hampel, A.1    Tritz, R.2
  • 42
    • 0025021952 scopus 로고
    • "Hairpin" catalytic RNA model: Evidence for helices and sequence requirement for substrate RNA
    • Hampel, A., Tritz, R., Hicks, M. and Cruz, P. (1990) "Hairpin" catalytic RNA model: evidence for helices and sequence requirement for substrate RNA. Nucl. Acids Res. 18: 299-304.
    • (1990) Nucl. Acids Res. , vol.18 , pp. 299-304
    • Hampel, A.1    Tritz, R.2    Hicks, M.3    Cruz, P.4
  • 43
    • 0025823653 scopus 로고
    • Polyamines favor DNA triplex formation at neutral pH
    • Hampel, K. J., Crosson, P. and Lee, J. S. (1991) Polyamines favor DNA triplex formation at neutral pH. Biochemistry 30: 4455-4459.
    • (1991) Biochemistry , vol.30 , pp. 4455-4459
    • Hampel, K.J.1    Crosson, P.2    Lee, J.S.3
  • 44
    • 0027405575 scopus 로고
    • Plasmid dimerization mediated by triplex formation between polypyrimidine-polypurine repeats
    • Hampel, K. J., Burkholder, G. D. and Lee, J. S. (1993) Plasmid dimerization mediated by triplex formation between polypyrimidine-polypurine repeats. Biochemistry 32: 1072-1077.
    • (1993) Biochemistry , vol.32 , pp. 1072-1077
    • Hampel, K.J.1    Burkholder, G.D.2    Lee, J.S.3
  • 45
    • 0027460804 scopus 로고
    • In vitro cleavage of HPV16 E6 and E7 RNA fragments by synthetic ribozymes and transcribed ribozymes from RNA-trimming plasmids
    • He, Y.-K., Lu, C. D. and Qi, G. (1993) In vitro cleavage of HPV16 E6 and E7 RNA fragments by synthetic ribozymes and transcribed ribozymes from RNA-trimming plasmids. FEBS Lett. 322: 21-24.
    • (1993) FEBS Lett. , vol.322 , pp. 21-24
    • He, Y.-K.1    Lu, C.D.2    Qi, G.3
  • 46
    • 0026053099 scopus 로고
    • Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides
    • Hélène, C. (1991) Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides. Eur. J. Cancer 27: 1466-1471.
    • (1991) Eur. J. Cancer , vol.27 , pp. 1466-1471
    • Hélène, C.1
  • 47
    • 0027300762 scopus 로고
    • A unique c-myc-targeted triplex-forming oligonucleotide inhibits the growth of ovarian and cervical carcinomas in vitro
    • Helm, C. W., Shrestha, K., Thomas, S., Shingleton, H. M. and Miller, D. M. (1993) A unique c-myc-targeted triplex-forming oligonucleotide inhibits the growth of ovarian and cervical carcinomas in vitro. Gynecol. Oncol. 49: 339-343.
    • (1993) Gynecol. Oncol. , vol.49 , pp. 339-343
    • Helm, C.W.1    Shrestha, K.2    Thomas, S.3    Shingleton, H.M.4    Miller, D.M.5
  • 48
    • 0025850802 scopus 로고
    • Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: More isn't always better
    • Herschlag, D. (1991) Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better. Proc. Natl. Acad. Sci. USA 88: 6921-6925.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6921-6925
    • Herschlag, D.1
  • 50
    • 0028169597 scopus 로고
    • Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme
    • Holm, P. S., Scanlon, K. J. and Dietel, M. (1994) Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme. Br. J. Cancer 70: 239-243.
    • (1994) Br. J. Cancer , vol.70 , pp. 239-243
    • Holm, P.S.1    Scanlon, K.J.2    Dietel, M.3
  • 51
    • 0029565726 scopus 로고    scopus 로고
    • Similar cleavage efficiencies of an oligoribonucleotide substrate and an mdr1 mRNA segment by a hammerhead ribozyme
    • Holm, P. S., Dietel, M. and Krupp, G. (1996) Similar cleavage efficiencies of an oligoribonucleotide substrate and an mdr1 mRNA segment by a hammerhead ribozyme. Gene 167: 221-225.
    • (1996) Gene , vol.167 , pp. 221-225
    • Holm, P.S.1    Dietel, M.2    Krupp, G.3
  • 52
    • 0026074818 scopus 로고
    • Cooperation between oncogenes
    • Hunter, T. (1991) Cooperation between oncogenes. Cell 64: 249-270.
    • (1991) Cell , vol.64 , pp. 249-270
    • Hunter, T.1
  • 53
    • 0024211331 scopus 로고
    • Antisense RNA: Its functions and applications in gene regulation-a review
    • Inouye, M. (1988) Antisense RNA: its functions and applications in gene regulation-a review. Gene 72: 25-34.
    • (1988) Gene , vol.72 , pp. 25-34
    • Inouye, M.1
  • 54
    • 0021229867 scopus 로고
    • Inhibition of thymidine kinase gene expression by antisense RNA: A molecular approach to genetic analysis
    • Izant, J. G. and Weintraub, H. (1984) Inhibition of thymidine kinase gene expression by antisense RNA: a molecular approach to genetic analysis. Cell 36: 1007-1010.
    • (1984) Cell , vol.36 , pp. 1007-1010
    • Izant, J.G.1    Weintraub, H.2
  • 55
    • 0026617011 scopus 로고
    • Oligonucleotide-directed triple helix formation at adjacent oligopurine and oligopyrimidine DNA tracts by alternate strand recognition
    • Jayasena, S. D. and Johnston, B. H. (1992) Oligonucleotide-directed triple helix formation at adjacent oligopurine and oligopyrimidine DNA tracts by alternate strand recognition. Nucl. Acids Res. 20: 5279-5288.
    • (1992) Nucl. Acids Res. , vol.20 , pp. 5279-5288
    • Jayasena, S.D.1    Johnston, B.H.2
  • 56
    • 0027245412 scopus 로고
    • 7,8-Dihydro-8-oxoademne as a replacement for cytosine in the third strand of triple helices. Triplex formation without hypochromicity
    • Jetter, M. C. and Hobbs, F. W. (1993) 7,8-Dihydro-8-oxoademne as a replacement for cytosine in the third strand of triple helices. Triplex formation without hypochromicity. Biochemistry 32: 3249-3254.
    • (1993) Biochemistry , vol.32 , pp. 3249-3254
    • Jetter, M.C.1    Hobbs, F.W.2
  • 57
    • 0024300366 scopus 로고
    • n: Chemical evidence for a three-stranded structure in plasmids
    • n: chemical evidence for a three-stranded structure in plasmids. Science 241: 1800-1804.
    • (1988) Science , vol.241 , pp. 1800-1804
    • Johnston, B.H.1
  • 58
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano, R. L. and Ling, V. (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochem. Biophys. Acta 455: 152-162.
    • (1976) Biochem. Biophys. Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 59
    • 0020578356 scopus 로고
    • Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines
    • Kartner, N., Riordan, J. R. and Ling, V. (1983) Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 221: 1285-1288.
    • (1983) Science , vol.221 , pp. 1285-1288
    • Kartner, N.1    Riordan, J.R.2    Ling, V.3
  • 60
    • 0021852930 scopus 로고
    • Detection of P-glycoprotein in multidrug resistant cell lines by monoclonal antibodies
    • Kartner, N., Evernden-Porelle, D., Bradley, G. and Ling, V. (1985) Detection of P-glycoprotein in multidrug resistant cell lines by monoclonal antibodies. Nature (London) 316: 820-823.
    • (1985) Nature (London) , vol.316 , pp. 820-823
    • Kartner, N.1    Evernden-Porelle, D.2    Bradley, G.3    Ling, V.4
  • 64
    • 0028071663 scopus 로고
    • Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells
    • Kiehntopf, M., Brach, M. A., Licht, T., Petschauer, S., Karawajew, L., Kirschning, C. and Hermann, F. (1994) Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells. EMBO J. 13: 4645-4652.
    • (1994) EMBO J. , vol.13 , pp. 4645-4652
    • Kiehntopf, M.1    Brach, M.A.2    Licht, T.3    Petschauer, S.4    Karawajew, L.5    Kirschning, C.6    Hermann, F.7
  • 66
    • 0001984357 scopus 로고    scopus 로고
    • Ribozyme-mediated reversal of human pancreatic carcinoma phenotype
    • Ikehara, S., Takaku, F. and Good, R. A. (eds.) Springer-Verlag, Tokyo
    • Kijima, H., Bouffard, D. Y. and Scanlon, K. J. (1996) Ribozyme-mediated reversal of human pancreatic carcinoma phenotype. In: Bone Marrow Transplantation-Basic and Clinical Studies, pp. 153-163, Ikehara, S., Takaku, F. and Good, R. A. (eds.) Springer-Verlag, Tokyo.
    • (1996) Bone Marrow Transplantation-Basic and Clinical Studies , pp. 153-163
    • Kijima, H.1    Bouffard, D.Y.2    Scanlon, K.J.3
  • 67
    • 0028231401 scopus 로고
    • Reversal of drug sensitivity in multidrug-resistant tumor cells by MDR-1 (PGY-1) ribozyme
    • Kobayashi, H., Dorai, T., Holland, J. F. and Ohnuma, T. (1994) Reversal of drug sensitivity in multidrug-resistant tumor cells by MDR-1 (PGY-1) ribozyme. Cancer Res. 54: 1271-1275.
    • (1994) Cancer Res. , vol.54 , pp. 1271-1275
    • Kobayashi, H.1    Dorai, T.2    Holland, J.F.3    Ohnuma, T.4
  • 68
    • 1642631504 scopus 로고
    • Design of a non natural deoxyribonucleoside for recognition of GC base pairs by oligonucleotide-directed triple helix formation
    • Koh, J. S. and Dervan, P. B. (1992) Design of a non natural deoxyribonucleoside for recognition of GC base pairs by oligonucleotide-directed triple helix formation. J. Am. Chem. Soc. 114: 1470-1478.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 1470-1478
    • Koh, J.S.1    Dervan, P.B.2
  • 70
    • 0026653293 scopus 로고
    • Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene
    • Koizumi, M., Kamiya, H. and Ohtsuka, E. (1992) Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene. Gene 117: 179-184.
    • (1992) Gene , vol.117 , pp. 179-184
    • Koizumi, M.1    Kamiya, H.2    Ohtsuka, E.3
  • 71
    • 0024297830 scopus 로고
    • Conferring operator specificity on restriction endonucleases
    • Koob, M., Grimes, E. and Szybalski, W. (1988) Conferring operator specificity on restriction endonucleases. Science 241: 1084-1086.
    • (1988) Science , vol.241 , pp. 1084-1086
    • Koob, M.1    Grimes, E.2    Szybalski, W.3
  • 73
    • 0020417286 scopus 로고
    • Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena
    • Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E. and Cech, T. R. (1982) Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 31: 147-157.
    • (1982) Cell , vol.31 , pp. 147-157
    • Kruger, K.1    Grabowski, P.J.2    Zaug, A.J.3    Sands, J.4    Gottschling, D.E.5    Cech, T.R.6
  • 74
    • 0029119820 scopus 로고
    • Artificial evolution and natural ribozymes
    • Kumar, P. K. R. and Ellington, A. D. (1995) Artificial evolution and natural ribozymes. FASEB J. 9: 1183-1195.
    • (1995) FASEB J. , vol.9 , pp. 1183-1195
    • Kumar, P.K.R.1    Ellington, A.D.2
  • 75
    • 0027979491 scopus 로고
    • Chemical probing studies of variants of the genomic hepatitis delta virus ribozyme by primer extension analysis
    • Kumar, P. K. R., Taira, K. and Nishikawa, S. (1994) Chemical probing studies of variants of the genomic hepatitis delta virus ribozyme by primer extension analysis. Biochemistry 33: 583-592.
    • (1994) Biochemistry , vol.33 , pp. 583-592
    • Kumar, P.K.R.1    Taira, K.2    Nishikawa, S.3
  • 76
    • 0023753576 scopus 로고
    • The molecular genetics of Philadelphia chromosome-positive leukemias
    • Kurzock, R., Gutterman, J. U. and Talpaz, M. (1988) The molecular genetics of Philadelphia chromosome-positive leukemias. N. Engl. J. Med. 319:990-998.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 990-998
    • Kurzock, R.1    Gutterman, J.U.2    Talpaz, M.3
  • 77
    • 0026680464 scopus 로고
    • Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription
    • Lechner, M. S., Mack, D. H., Finicle, A. B., Crook, T., Vousden, K. H. and Laimins, L. A. (1992) Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription. EMBO J. 11: 3045-3052.
    • (1992) EMBO J. , vol.11 , pp. 3045-3052
    • Lechner, M.S.1    Mack, D.H.2    Finicle, A.B.3    Crook, T.4    Vousden, K.H.5    Laimins, L.A.6
  • 78
    • 0023652076 scopus 로고
    • Sequence-specific recognition photo crosslinking and cleavage of the DNA double helix by an oligo-[alpha]- thymidylate covalently linked to an azidoproflavine derivatives
    • Le Doan, T., Perrouault, L., Praseuth, D., Habhoub, N., Decout, J. L., Thoung, T., Lhomme, J. and Hélène, C. (1987) Sequence-specific recognition photo crosslinking and cleavage of the DNA double helix by an oligo-[alpha]- thymidylate covalently linked to an azidoproflavine derivatives. Nucl. Acids Res. 15: 7749-7760.
    • (1987) Nucl. Acids Res. , vol.15 , pp. 7749-7760
    • Le Doan, T.1    Perrouault, L.2    Praseuth, D.3    Habhoub, N.4    Decout, J.L.5    Thoung, T.6    Lhomme, J.7    Hélène, C.8
  • 79
    • 0018788076 scopus 로고
    • Complexes formed by (pyrimidine)n . (purine)n DNAs on lowering the pH are three stranded
    • Lee, J. S., Johnson, D. A. and Morgan, A. R. (1979) Complexes formed by (pyrimidine)n . (purine)n DNAs on lowering the pH are three stranded. Nucl. Acids Res. 6: 3073-3091.
    • (1979) Nucl. Acids Res. , vol.6 , pp. 3073-3091
    • Lee, J.S.1    Johnson, D.A.2    Morgan, A.R.3
  • 80
    • 0021769970 scopus 로고
    • Poly(pyrimidine)·- poly(purine) synthetic DNAs containing 5-methylcytosine form stable triplexes at neutral pH
    • Lee, J. S., Woodsworth, M. L., Latimer, L. J. and Moran, J. R. (1984) Poly(pyrimidine)·- poly(purine) synthetic DNAs containing 5-methylcytosine form stable triplexes at neutral pH. Nucl. Acids Res. 12: 6603-6614.
    • (1984) Nucl. Acids Res. , vol.12 , pp. 6603-6614
    • Lee, J.S.1    Woodsworth, M.L.2    Latimer, L.J.3    Moran, J.R.4
  • 81
    • 0000359889 scopus 로고
    • Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site
    • Lemaitre, M., Bayard, B. and Lebleu, B. (1987) Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. Proc. Natl. Acad. Sci. USA 84: 648-652.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 648-652
    • Lemaitre, M.1    Bayard, B.2    Lebleu, B.3
  • 82
    • 0025271668 scopus 로고
    • Antibody-targeted liposomes containing oligodeoxynucleotides complementary to viral RNA selectively inhibits viral replication
    • Leonetti, J. P., Machy, P., Degols, G., Lebleu, B. and Leserman, L. (1990) Antibody-targeted liposomes containing oligodeoxynucleotides complementary to viral RNA selectively inhibits viral replication. Proc. Natl. Acad. Sci. USA 87: 2448-2451.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2448-2451
    • Leonetti, J.P.1    Machy, P.2    Degols, G.3    Lebleu, B.4    Leserman, L.5
  • 84
    • 0028939524 scopus 로고
    • Multi-unit ribozyme mediated cleavage of bcr-abl mRNA in myeloid leukemias
    • Leopold, L. H., Shore, S. K., Newkirk, T. A., Reddy, R. M. V. and Reddy, E. P. (1995) Multi-unit ribozyme mediated cleavage of bcr-abl mRNA in myeloid leukemias. Blood 85: 2162-2170.
    • (1995) Blood , vol.85 , pp. 2162-2170
    • Leopold, L.H.1    Shore, S.K.2    Newkirk, T.A.3    Reddy, R.M.V.4    Reddy, E.P.5
  • 85
    • 0024298583 scopus 로고
    • Specificity in formation triple-stranded nucleic acid helical complexes: Studies with agarose-linked poly-ribonucleotide affinity columns
    • Letai, A. G., Palladino, M. A., Fromm, E., Rizzo, V. and Fresco, J. R. (1988) Specificity in formation triple-stranded nucleic acid helical complexes: studies with agarose-linked poly-ribonucleotide affinity columns. Biochemistry 28: 9108-9112.
    • (1988) Biochemistry , vol.28 , pp. 9108-9112
    • Letai, A.G.1    Palladino, M.A.2    Fromm, E.3    Rizzo, V.4    Fresco, J.R.5
  • 86
    • 0027243302 scopus 로고
    • Long-term treatment of human immunodeficiency virus-infected cells with anti-sense oligonucleotide phosphorothioates
    • Lisziewicz, J., Sun, D., Metelev, V., Zamecnik, P., Gallo, R. C. and Agrawal, S. (1993) Long-term treatment of human immunodeficiency virus-infected cells with anti-sense oligonucleotide phosphorothioates. Proc. Natl. Acad. Sci. USA 90: 3860-3864.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3860-3864
    • Lisziewicz, J.1    Sun, D.2    Metelev, V.3    Zamecnik, P.4    Gallo, R.C.5    Agrawal, S.6
  • 88
    • 0028700483 scopus 로고
    • Ribozyme-mediated in vitro cleavage of transcripts arising from the major transforming genes of human papillomavirus type 16
    • Lu, C. D., Chatterjee, S., Brar, D. and Wong, K. K., Jr. (1994) Ribozyme-mediated in vitro cleavage of transcripts arising from the major transforming genes of human papillomavirus type 16. Cancer Gene Ther. 1: 267-277.
    • (1994) Cancer Gene Ther. , vol.1 , pp. 267-277
    • Lu, C.D.1    Chatterjee, S.2    Brar, D.3    Wong K.K., Jr.4
  • 91
    • 0024296477 scopus 로고
    • A stable complex between homopyrimidine oligomers and the homologous regions of duplex DNAs
    • Lyamichev, V. I., Mirkin, S. M., Frank-Kamenetskii, M. D. and Cantor, C. R. (1988) A stable complex between homopyrimidine oligomers and the homologous regions of duplex DNAs. Nucl. Acids Res. 16: 2165-2178.
    • (1988) Nucl. Acids Res. , vol.16 , pp. 2165-2178
    • Lyamichev, V.I.1    Mirkin, S.M.2    Frank-Kamenetskii, M.D.3    Cantor, C.R.4
  • 92
    • 0024357372 scopus 로고
    • Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation
    • Maher, L. J., Wold, B. and Dervan, P. B. (1989) Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation. Science 245: 725-730.
    • (1989) Science , vol.245 , pp. 725-730
    • Maher, L.J.1    Wold, B.2    Dervan, P.B.3
  • 93
    • 0026567095 scopus 로고
    • Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system
    • Maher, L. J., Dervan, P. B. and Wold, B. (1992) Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system. Biochemistry 31: 70-81.
    • (1992) Biochemistry , vol.31 , pp. 70-81
    • Maher, L.J.1    Dervan, P.B.2    Wold, B.3
  • 94
    • 0028876993 scopus 로고
    • Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21)
    • Matsushita, H., Kobayashi, H., Mori, S., Kizaki, M. and Ikeda, Y. (1995) Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21). Biochem. Biophys. Res. Commun. 215: 431-437.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 431-437
    • Matsushita, H.1    Kobayashi, H.2    Mori, S.3    Kizaki, M.4    Ikeda, Y.5
  • 95
    • 0028235646 scopus 로고
    • Triplex formation by the human Haras promoter inhibits Sp1 binding and in vitro transcription
    • Mayfield, C., Ebbinghaus, S., Gee, J., Jones, D., Rodu, B., Squibb, M. and Miller, D. (1994) Triplex formation by the human Haras promoter inhibits Sp1 binding and in vitro transcription. J. Biol. Chem. 269: 18232-18238.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18232-18238
    • Mayfield, C.1    Ebbinghaus, S.2    Gee, J.3    Jones, D.4    Rodu, B.5    Squibb, M.6    Miller, D.7
  • 97
    • 0026726784 scopus 로고
    • Inhibition of transcription of HIV-1 in infected human cells by oligonucleotides designed to form DNA triple helices
    • McShan, W. M., Rossen, R. D., Laughter, A. H., Trial, J., Kessler, D. J., Zendegui, J. G., Hogan, M. E. and Orson, F. M. (1992) Inhibition of transcription of HIV-1 in infected human cells by oligonucleotides designed to form DNA triple helices. J. Biol. Chem. 267: 5712-5721.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5712-5721
    • McShan, W.M.1    Rossen, R.D.2    Laughter, A.H.3    Trial, J.4    Kessler, D.J.5    Zendegui, J.G.6    Hogan, M.E.7    Orson, F.M.8
  • 98
    • 0343531938 scopus 로고
    • Injected antisense RNAs specifically block messenger RNA translation in vivo
    • Melton, D. A. (1985) Injected antisense RNAs specifically block messenger RNA translation in vivo. Proc. Natl. Acad. Sci. USA 82: 144-148.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 144-148
    • Melton, D.A.1
  • 99
    • 0025942240 scopus 로고
    • Sequence specificity on triple-helix formation: Experimental and theoretical studies of the effect of mismatches on triplex stability
    • Mergny, J.-L., Sun, J.-S., Rougee, M., Montenay-Garesteir, T., Barcelo, F., Chomilier, J. and Hélène, C. (1991) Sequence specificity on triple-helix formation: experimental and theoretical studies of the effect of mismatches on triplex stability. Biochemistry 30: 9791-9798.
    • (1991) Biochemistry , vol.30 , pp. 9791-9798
    • Mergny, J.-L.1    Sun, J.-S.2    Rougee, M.3    Montenay-Garesteir, T.4    Barcelo, F.5    Chomilier, J.6    Hélène, C.7
  • 101
    • 0014414243 scopus 로고
    • Specificity of the three-stranded complex formation between double-stranded DNA and single-stranded RNA containing repeating nucleotide sequences
    • Morgan, A. R. and Wells, R. D. (1968) Specificity of the three-stranded complex formation between double-stranded DNA and single-stranded RNA containing repeating nucleotide sequences. J. Mol. Biol. 37: 63-80.
    • (1968) J. Mol. Biol. , vol.37 , pp. 63-80
    • Morgan, A.R.1    Wells, R.D.2
  • 102
    • 0023619361 scopus 로고
    • Sequence-specific cleavage of double helical DNA by triple helix formation
    • Moser, H. E. and Dervan, P. B. (1987) Sequence-specific cleavage of double helical DNA by triple helix formation. Science 238: 645-650.
    • (1987) Science , vol.238 , pp. 645-650
    • Moser, H.E.1    Dervan, P.B.2
  • 103
    • 0028288222 scopus 로고
    • Triple helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence
    • Mouscadet, J. F., Ketterlé, C., Goulaouic, H., Carteau, S., Subra, F., Le Bref, M. and Auclair, C. (1994) Triple helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence. Biochemistry 33: 4187-4196.
    • (1994) Biochemistry , vol.33 , pp. 4187-4196
    • Mouscadet, J.F.1    Ketterlé, C.2    Goulaouic, H.3    Carteau, S.4    Subra, F.5    Le Bref, M.6    Auclair, C.7
  • 104
    • 0025868669 scopus 로고
    • Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA
    • Mukhopadhyay, T., Tansky, M., Cavender, A. and Roth, J. A. (1991) Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res. 51: 1744-1748.
    • (1991) Cancer Res. , vol.51 , pp. 1744-1748
    • Mukhopadhyay, T.1    Tansky, M.2    Cavender, A.3    Roth, J.A.4
  • 106
    • 0029102906 scopus 로고
    • Ribozyme: From mechanistic studies to applications in vivo
    • Ohkawa, J., Koguma, T., Okhda, T. and Taira, K. (1995) Ribozyme: from mechanistic studies to applications in vivo. J. Biochem. 118: 251-258.
    • (1995) J. Biochem. , vol.118 , pp. 251-258
    • Ohkawa, J.1    Koguma, T.2    Okhda, T.3    Taira, K.4
  • 108
    • 0029918906 scopus 로고    scopus 로고
    • Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells
    • Ohta, Y., Kijima, H., Kashani-Sabet, M. and Scanlon, K. J. (1996a) Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells. Nucl. Acids Res. 24: 938-942.
    • (1996) Nucl. Acids Res. , vol.24 , pp. 938-942
    • Ohta, Y.1    Kijima, H.2    Kashani-Sabet, M.3    Scanlon, K.J.4
  • 109
    • 0029866954 scopus 로고    scopus 로고
    • Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes
    • Ohta, Y., Kijima, H., Kashani-Sabet, M. and Scanlon, K. J. (1996b) Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes. J. Invest. Dermatol. 106: 275-280.
    • (1996) J. Invest. Dermatol. , vol.106 , pp. 275-280
    • Ohta, Y.1    Kijima, H.2    Kashani-Sabet, M.3    Scanlon, K.J.4
  • 110
    • 0025830451 scopus 로고
    • Triplex formation of oligonucleotides containing 2′-O-methylpseudoisocytidine in substitution for 2′-deoxycytidine
    • Ono, A., Ts'o, P. O. P. and Kan, L.-S. (1991) Triplex formation of oligonucleotides containing 2′-O-methylpseudoisocytidine in substitution for 2′-deoxycytidine. Am. Chem. Soc. 113: 4032-4033.
    • (1991) Am. Chem. Soc. , vol.113 , pp. 4032-4033
    • Ono, A.1    Ts'o, P.O.P.2    Kan, L.-S.3
  • 111
    • 0025894851 scopus 로고
    • Oligonucleotide inhibition of IL2R alpha mRNA transcription by promoter region colinear triplex formation in lymphocytes
    • Orson, F. M., Thomas, D. W., McShan, W. M., Kessler, D. J. and Hogan, M. E. (1991) Oligonucleotide inhibition of IL2R alpha mRNA transcription by promoter region colinear triplex formation in lymphocytes. Nucl. Acids Res. 19: 3435-3441.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 3435-3441
    • Orson, F.M.1    Thomas, D.W.2    McShan, W.M.3    Kessler, D.J.4    Hogan, M.E.5
  • 112
    • 0028352070 scopus 로고
    • Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides
    • Orson, F. M., Kinsey, B. M. and McShan, W. M. (1994) Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides. Nucl. Acids Res. 22: 479-484.
    • (1994) Nucl. Acids Res. , vol.22 , pp. 479-484
    • Orson, F.M.1    Kinsey, B.M.2    McShan, W.M.3
  • 113
    • 0028318142 scopus 로고
    • Selective cleavage of bcr-abl chimeric RNAs by a ribozyme targeted to noncontinuous sequences
    • Pachuk, C. J., Yoon, K., Moelling, K. and Coney, L. R. (1993) Selective cleavage of bcr-abl chimeric RNAs by a ribozyme targeted to noncontinuous sequences. Nucl. Acids Res. 22: 301-307.
    • (1993) Nucl. Acids Res. , vol.22 , pp. 301-307
    • Pachuk, C.J.1    Yoon, K.2    Moelling, K.3    Coney, L.R.4
  • 114
    • 0026594927 scopus 로고
    • Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis virus RNA sequence
    • Perotta, A. T. and Been, M. D. (1992) Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis virus RNA sequence. Biochemistry 31: 16-21.
    • (1992) Biochemistry , vol.31 , pp. 16-21
    • Perotta, A.T.1    Been, M.D.2
  • 116
    • 0011084381 scopus 로고
    • Site-specific cleavage of duplex DNA by a semi-synthetic nuclease via triple-helix formation
    • Pie, D., Corey, D. R. and Schultz, P. C. (1990) Site-specific cleavage of duplex DNA by a semi-synthetic nuclease via triple-helix formation. Proc. Natl. Acad. Sci. USA 86: 9702-9706.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9702-9706
    • Pie, D.1    Corey, D.R.2    Schultz, P.C.3
  • 117
    • 0025604606 scopus 로고
    • Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: A spectroscopic and calorimetric study
    • Plum, G. E., Park, Y.-W., Singleton, S. F., Dervan, P. B. and Breslauer, K. J. (1990) Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study. Proc. Natl. Acad. Sci. USA 87: 9436-9440.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9436-9440
    • Plum, G.E.1    Park, Y.-W.2    Singleton, S.F.3    Dervan, P.B.4    Breslauer, K.J.5
  • 118
    • 0025744428 scopus 로고
    • Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels
    • Postel, E. H., Flint, S. J., Kessler, D. J. and Hogan, M. E. (1991) Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels. Proc. Natl. Acad. Sci. USA 88: 8227-8231.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8227-8231
    • Postel, E.H.1    Flint, S.J.2    Kessler, D.J.3    Hogan, M.E.4
  • 119
    • 0000778306 scopus 로고
    • Sequence-specific double strand alkylation and cleavage of DNA mediated by triple-helix formation
    • Povsic, T. J., Strobel, S. J. and Dervan, P. B. (1992) Sequence-specific double strand alkylation and cleavage of DNA mediated by triple-helix formation. J. Am. Chem. Soc. 114: 5934-5941.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 5934-5941
    • Povsic, T.J.1    Strobel, S.J.2    Dervan, P.B.3
  • 120
    • 0013947253 scopus 로고
    • Physical and chemical characterization of two- and three-stranded adeninethymine and adenine-uracil homopolymer complexes
    • Riley, M., Maling, B. and Chamberlin, M. J. (1966) Physical and chemical characterization of two- and three-stranded adeninethymine and adenine-uracil homopolymer complexes. J. Mol. Biol. 20: 359-389.
    • (1966) J. Mol. Biol. , vol.20 , pp. 359-389
    • Riley, M.1    Maling, B.2    Chamberlin, M.J.3
  • 121
    • 0027117408 scopus 로고
    • A signal chain of events
    • Roberts, T. M. (1992) A signal chain of events. Nature 360: 534-535.
    • (1992) Nature , vol.360 , pp. 534-535
    • Roberts, T.M.1
  • 124
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine flourescence and giemsa staining
    • Rowley, J. D. (1973) A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine flourescence and giemsa staining. Nature (Lond.) 243: 290-293.
    • (1973) Nature (Lond.) , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 125
    • 0028110360 scopus 로고
    • Ribozyme-mediated reversal of the multidrug-resistant phenotype
    • Scanlon, K. J., Ishida, H. and Kashani-Sabet, M. (1994) Ribozyme-mediated reversal of the multidrug-resistant phenotype. Proc. Natl. Acad. Sci. USA 91: 11123-11127.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11123-11127
    • Scanlon, K.J.1    Ishida, H.2    Kashani-Sabet, M.3
  • 126
    • 0027384743 scopus 로고
    • Ribozyme-mediated cleavage of the BCR/ABL oncogene transcript; in vitro cleavage of RNA and in vivo loss of P210 protein kinase activity
    • Shore, S. K., Nabriss, P. M. and Reddy, E. P. (1993) Ribozyme-mediated cleavage of the BCR/ABL oncogene transcript; in vitro cleavage of RNA and in vivo loss of P210 protein kinase activity. Oncogene 8: 3183-3188.
    • (1993) Oncogene , vol.8 , pp. 3183-3188
    • Shore, S.K.1    Nabriss, P.M.2    Reddy, E.P.3
  • 128
    • 0027218359 scopus 로고
    • Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line
    • Snyder, D. S., Wu, Y., Wang, J. L., Rossi, J. J., Swiderski, P., Kaplan, B. E. and Forman, S. J. (1993) Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line. Blood 82: 600-605.
    • (1993) Blood , vol.82 , pp. 600-605
    • Snyder, D.S.1    Wu, Y.2    Wang, J.L.3    Rossi, J.J.4    Swiderski, P.5    Kaplan, B.E.6    Forman, S.J.7
  • 129
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • Stehelin, D., Varmus, H. E., Bishop, J. M. and Vogt, P. K. (1976) DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260: 170-173.
    • (1976) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 130
    • 0027376439 scopus 로고
    • Antisense oligonucleotides as therapeutic agents - Is the bullet really magical?
    • Stein, C. A. and Cheng, Y.-C. (1993) Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261: 1004-1012.
    • (1993) Science , vol.261 , pp. 1004-1012
    • Stein, C.A.1    Cheng, Y.-C.2
  • 132
    • 0025797398 scopus 로고
    • Single-site enzymatic cleavage of yeast genomic DNA mediated by triple-helix formation
    • Strobel, S. A. and Dervan, P. B. (1991) Single-site enzymatic cleavage of yeast genomic DNA mediated by triple-helix formation. Nature 350: 172-174.
    • (1991) Nature , vol.350 , pp. 172-174
    • Strobel, S.A.1    Dervan, P.B.2
  • 136
    • 0026213268 scopus 로고
    • Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgpl reveals that the AP-1 site is essential for full promoter activity
    • Teeter, L. D., Eckersberg, T., Tsai, Y. and Kuo, M. T. (1991) Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgpl reveals that the AP-1 site is essential for full promoter activity. Cell Growth Differ. 2: 429-437.
    • (1991) Cell Growth Differ. , vol.2 , pp. 429-437
    • Teeter, L.D.1    Eckersberg, T.2    Tsai, Y.3    Kuo, M.T.4
  • 137
    • 0027222970 scopus 로고
    • Structural and sequence elements required for the self-cleaving activity of the hepatitis delta virus ribozyme
    • Thill, G., Vasseur, M. and Tanner, N. K. (1993) Structural and sequence elements required for the self-cleaving activity of the hepatitis delta virus ribozyme. Biochemistry 32: 4254-4262.
    • (1993) Biochemistry , vol.32 , pp. 4254-4262
    • Thill, G.1    Vasseur, M.2    Tanner, N.K.3
  • 139
    • 0027973506 scopus 로고
    • A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements
    • Tuschl, T., Gohlke, C., Jovin, T. M., Westhof, E. and Eckstein, F. (1994) A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements. Science 266: 785-788.
    • (1994) Science , vol.266 , pp. 785-788
    • Tuschl, T.1    Gohlke, C.2    Jovin, T.M.3    Westhof, E.4    Eckstein, F.5
  • 140
    • 0023221419 scopus 로고
    • A small catalytic oligoribonucleotide
    • Uhlenbeck, O. C. (1987) A small catalytic oligoribonucleotide. Nature (Lond.) 328: 596-600.
    • (1987) Nature (Lond.) , vol.328 , pp. 596-600
    • Uhlenbeck, O.C.1
  • 141
    • 0025335881 scopus 로고
    • Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration
    • van Tol, H., Buzayan, J. M., Feldstein, P. A., Eckstein, F. and Bruening, G. (1990) Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration. Nucl. Acids Res. 18: 1971-1975.
    • (1990) Nucl. Acids Res. , vol.18 , pp. 1971-1975
    • Van Tol, H.1    Buzayan, J.M.2    Feldstein, P.A.3    Eckstein, F.4    Bruening, G.5
  • 142
    • 0023891065 scopus 로고
    • Expression of c-sis (PDGF-B chain) and PDGF-A chain genes in ten human malignant mesothelioma cell lines derived from primary and metastatic tumors
    • Versnel, M. A., Hagemeijer, A., Bouts, M. J., van der Kwast, T. H. and Hoogesteden, H. C. (1988) Expression of c-sis (PDGF-B chain) and PDGF-A chain genes in ten human malignant mesothelioma cell lines derived from primary and metastatic tumors. Oncogene 2: 601-605.
    • (1988) Oncogene , vol.2 , pp. 601-605
    • Versnel, M.A.1    Hagemeijer, A.2    Bouts, M.J.3    Van Der Kwast, T.H.4    Hoogesteden, H.C.5
  • 144
    • 0024041180 scopus 로고
    • Role of RNase H in hybrid arrested translation by antisense oligonucleotides
    • Walder, R. W. and Walder, J. A. (1988) Role of RNase H in hybrid arrested translation by antisense oligonucleotides. Proc. Natl. Acad. Sci. USA 85: 5011-5015.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5011-5015
    • Walder, R.W.1    Walder, J.A.2
  • 145
    • 0028829786 scopus 로고
    • Improved cellular delivery of antisense oligonucleotides using transferrin receptor antibody-oligonucleotide conjugates
    • Walker, I., Irwin, W. J. and Akhtar, S. (1995) Improved cellular delivery of antisense oligonucleotides using transferrin receptor antibody-oligonucleotide conjugates. Pharm. Res. 12: 1548-1553.
    • (1995) Pharm. Res. , vol.12 , pp. 1548-1553
    • Walker, I.1    Irwin, W.J.2    Akhtar, S.3
  • 147
    • 0022449061 scopus 로고    scopus 로고
    • Wang, K.-S., Choo, Q.-L., Weiner, A. J., Ou, J.-H., Najarian, R. C., Thayer, R. M., Mullenbach, G. T., Denninston, K. J., Gerin, J. L. and Houghton, M. (1986) Structure, sequence and expression of the hepatitis delta (d) viral genome. Nature (Lond.) 323: 508-514. Corrigendum: Nature (Lond.) 328: 456.
    • Corrigendum: Nature (Lond.) , vol.328 , pp. 456
  • 148
    • 0025271203 scopus 로고
    • Association of human papillomavirus type 16 and 18 E6 protein with P53
    • Werness, B. A., Levine, A. J. and Howley, P. M. (1990) Association of human papillomavirus type 16 and 18 E6 protein with P53. Science 248: 76-79.
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 149
    • 0026295042 scopus 로고
    • In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide
    • Whitesell, L., Rosolen, A. and Neckers, L. M. (1991) In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide. Antisense Res. Dev. 1: 343-350.
    • (1991) Antisense Res. Dev. , vol.1 , pp. 343-350
    • Whitesell, L.1    Rosolen, A.2    Neckers, L.M.3
  • 150
    • 0001520251 scopus 로고
    • Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA
    • Wickstrom, E. L., Bacon, T. A., Gonzalez, A., Freeman, D. L., Lyman, G. H. and Wickstrom, E. (1988) Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. Proc. Natl. Acad. Sci. USA 85: 1028-1032.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1028-1032
    • Wickstrom, E.L.1    Bacon, T.A.2    Gonzalez, A.3    Freeman, D.L.4    Lyman, G.H.5    Wickstrom, E.6
  • 151
    • 0027093252 scopus 로고
    • Down-regulation of c-MYC antigen expression in lymphocytes of Eμ,-c-myc transgenic mice treated with anti-c-myc DNA methylphosphonates
    • Wickstrom, E., Bacon, T. A. and Wickstrom, E. L. (1992) Down-regulation of c-MYC antigen expression in lymphocytes of Eμ,-c-myc transgenic mice treated with anti-c-myc DNA methylphosphonates. Cancer Res. 52: 6741-6745.
    • (1992) Cancer Res. , vol.52 , pp. 6741-6745
    • Wickstrom, E.1    Bacon, T.A.2    Wickstrom, E.L.3
  • 152
    • 0026485009 scopus 로고
    • Specific inhibition of human immunodeficiency virus type 1 replication by anti-sense oligonucleotides: An in vitro model for treatment
    • Wicz, J., Sun, D., Klotman, M., Agrawal, S., Zamecnik, P. and Gallo, R. (1992) Specific inhibition of human immunodeficiency virus type 1 replication by anti-sense oligonucleotides: an in vitro model for treatment. Proc. Natl. Acad. Sci. USA 89: 11209-11213.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11209-11213
    • Wicz, J.1    Sun, D.2    Klotman, M.3    Agrawal, S.4    Zamecnik, P.5    Gallo, R.6
  • 153
    • 0023212742 scopus 로고
    • Receptor-mediated in vitro gene transformation by a soluble DNA carrier system
    • Wny, G. Y. and Wu, C. H. (1987) Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem. 262: 4429-4432.
    • (1987) J. Biol. Chem. , vol.262 , pp. 4429-4432
    • Wny, G.Y.1    Wu, C.H.2
  • 154
    • 0027819241 scopus 로고
    • Ribozyme mediated cleavage of the bcr/abl transcription expressed in chronic myeloid leukemia
    • Wright, L., Wilson, S. B., Milliken, S., Biggs, J. and Kearney, P. (1993) Ribozyme mediated cleavage of the bcr/abl transcription expressed in chronic myeloid leukemia. Exp. Hematol. 21: 1714-1718.
    • (1993) Exp. Hematol. , vol.21 , pp. 1714-1718
    • Wright, L.1    Wilson, S.B.2    Milliken, S.3    Biggs, J.4    Kearney, P.5
  • 155
    • 0023568276 scopus 로고
    • Transcriptional control of endogenous MYC proto-oncogenes by antisense RNA
    • Yokoyama, K. and Imamoto, F. (1987) Transcriptional control of endogenous MYC proto-oncogenes by antisense RNA. Proc. Natl. Acad. Sci. USA 84: 7363-7367.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7363-7367
    • Yokoyama, K.1    Imamoto, F.2
  • 156
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • Zamecnik, P. C. and Stephenson, M. L. (1978) Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA 75: 280-284.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 280-284
    • Zamecnik, P.C.1    Stephenson, M.L.2
  • 157
    • 0001477721 scopus 로고
    • Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA
    • Zamecnik, P. C., Goodchild, J., Taguchi, Y. and Sarin, P. S. (1986) Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA. Proc. Natl. Acad. Sci. USA 83: 4143-4146.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 4143-4146
    • Zamecnik, P.C.1    Goodchild, J.2    Taguchi, Y.3    Sarin, P.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.