Toroidal structure of λ-exonuclease

Science

Volumn 277, Issue 5333, 1997, Pages 1824-1827

  Kovall, Rhett ^a   Matthews, Brian W ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXONUCLEASE;

ARTICLE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENETIC RECOMBINATION; HYDROLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

BACTERIOPHAGE LAMBDA; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA; DNA, SINGLE-STRANDED; DNA, VIRAL; EVOLUTION, MOLECULAR; EXODEOXYRIBONUCLEASES; HYDROLYSIS; MAGNESIUM; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINATION, GENETIC; VIRAL PROTEINS;

EID: 0030881051     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5333.1824     Document Type: Article

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47. We thank Dr. R. Novy of Novagen for the clone; C. Ogata of the National Synchrotron Light Source, Brookhaven, and B. Miller and M. Szebonyi of CHESS for help with synchrotron data collection; M. Sagermann for advice on crystallographic aspects; D. Tronrud for modifying the TNT refinement package to permit anisotropic scaling; M. Quillin for comments on the manuscript; and R. Myers and members of F. Stahl's group for introducing us to λ-exonuclease. Supported in part by grant GM20066 from the NIH to B.W.M.