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Volumn 14, Issue 8, 1997, Pages 1026-1029

Prodrug and analog approaches to improving the intestinal absorption of a cyclic peptide, GPIIb/IIIa receptor antagonist

(2) Saitoh, Hiroshi a,b Aungst, Bruce J a

a DUPONT COMPANY (United States)

b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO (Japan)

Author keywords

Absorption; Analog; GPIIb IIIa antagonist; Intestinal permeability; Peptide; Prodrug

Indexed keywords

CYCLO(DEXTRO 2 AMINOBUTYRYL 2 N METHYLARGINYLGLYCYLASPARTYL 3 AMINOMETHYLBENZOIC ACID) METHANESULFONATE; FIBRINOGEN RECEPTOR ANTAGONIST; PRODRUG;

ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ABSORPTION; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; INTESTINAL ABSORPTION; MALE; MESYLATES; PEPTIDES, CYCLIC; PERMEABILITY; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030880662 PISSN: 07248741 EISSN: None Source Type: Journal
DOI: 10.1023/A:1012149227756 Document Type: Article

Times cited : (5)

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