Effect of hyperprolactinemia induced by neuroleptic agent, timiperone, on porphyrin content of mouse harderian gland

Journal of Toxicological Sciences

Volumn 22, Issue 3, 1997, Pages 219-229

  Kajimura, Tetsuyo ^a   Satoh, Hiroshi ^a   Nomura, Mamoru ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Harderian gland; Mouse; Neuroleptics; Porphyrin; Prolactin

Indexed keywords

BROMOCRIPTINE; HALOPERIDOL; NEUROLEPTIC AGENT; PORPHYRIN; PROLACTIN; TIMIPERONE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTRON MICROSCOPY; HARDER GLAND; HISTOLOGY; HYPERPROLACTINEMIA; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; SUBCUTANEOUS DRUG ADMINISTRATION; TISSUE LEVEL;

ANIMALIA;

EID: 0030880060     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.22.3_219     Document Type: Article

References (33)

1. Albini, B., Wick, G., Rose, E, and Orlans, E. (1974): Immunoglobulin production in chicken Harderian glands. Int. Arch. Allergy. Appl. Immunol., 47, 23-34.
2. Bartke, A. (1976): Pituitary-testis relationships. In Progress in Reproductive Biology (Hubinont, P.O., L'Hermite, H and Schwers, J.eds.) vol.1, p.136, Karger, Basel.
3. Buzzell, G.R., Menendes-Pelaez, A., Porkka-Heiskanen, T., Pangerl, A., Pangerl, B., Vaughan, M.K and Reiter, R.J. (1989): Bromocriptine prevents the castration-induced rise in porphyrin concentration in the Harderian glands of the male Syrian hamster, Mesocricetus auratus. J. Experimental Zoology, 249, 172-176.
4. Carriere, R. (1985): Ultrastructural visualization of intracellular porphyrin in the rat Harderian gland. Anat. Rec., 213, 496-504.
5. Clabough, J.W and Norvell, J.E. (1973): Effects of castration, blinding, and the pineal gland on the Harderian glands of the male golden hamster, Neuroendocrinology, 12, 334-353.
6. Dickerman, S., Kledzuk, G., Gelato, M., Chen, H.G and Meites, J. (1974): Effects of haloperidol on serum and pituitary prolactin, LH and FSH, and hypothalamic PIF and LRF. Neuroendocrinology, 15, 10-20.
7. Grafflin, A.L. (1942): Histological observations upon the porphyrin-excreting Harderian gland of the albino rat. Am. J. Anat., 71, 43-64
8. Gupta, S.K and Maiti, B.R. (1981): Action of prolactin on the Harderian gland of the chick. Gen. Comp. Endocrinol., 45, 289-292.
9. Hoffman, R.A. (1971): Influences of some endocrine glands, hormones and blinding of the histology and porphyrins of the Harderian glands of golden hamsters. Am. J. Anat., 132, 463-478.
10. Horowski, R and Graf, K.J. (1979): Neuroendocrine effects of neuropsychotrophic drugs and their possible influence on toxic reactions in animals and man - The role of the dopamine-prolactin system. Toxicol., Suppl. 2, 93-104.
11. Kennedy, G.Y. (1970): Harderoporphyrin: a new porphyrin from the Harderian glands of the rat. Com. Biochem. Physiol., 36, 21-36.
12. Mueller, AP., Sato, K and Glick, B. (1971): The chicken lacrimal gland, gland of Harder, caecal tonsil and accessory spleen as sources of antibody-producing cells. Cell Immunol., 2, 140-152.
13. Payne, A.P. (1977): Pheromonal effects of Harderian gland homogenates on aggressive behaviour in the hamster. J. Endocrinology, 73, 191-192.
14. Payne, A.P., McGadey, J., Moore, M.R., Thompson, G.G. (1977): Androgenic control of the Harderian gland in the male golden hamster. J. Endocrinol., 75, 73-82.
15. Reiter, R.J and Klien, D.C. (1971): Observations on the pineal gland, Harderian gland, the retina and the reproductive organs of adult female rats exposed to continuous light. J. Endocrinology, 51, 117-125.
16. Sakai, T. (1981): The mammalian Harderian gland: morphology, biochemistry, function and phylogeny. Arch. Histol. Jpn., 44, 299-333.
17. Shirama, K. (1978): Induction of persistent estrus by constant light: Effects of neonatal constant light and Harderian gland function. Neuroendocrinology, 27, 193-203.
18. Shirama, K., Furuya, T., Takeo, Y., Shimizu, Y and Maekawa, K. (1981): Influences of some endocrine glands and of hormone replacement on the porphyrins of the Harderian glands of mice. J. Endocrinology, 91, 305-311.
19. Shirama, K., Kohda, M., and Hokano, M. (1987): Effects of lighting conditions and of hormone replacement on the level of porphyrins in the rat Harderian gland. J. Endocrinol. Invest., 10, 79-82.
20. Sinha, Y.N., Selby, F.W., Lewis, U.J and Vanderlaan, W.P. (1972): Studies of prolactin secretion in mice by a homologous radioimmunoassay. Endocrinology, 91, 1045-1053.
21. Sinha, Y.N., Selby, F.W and Vanderlaan, W.P. (1974): Effects of ergot drugs on prolactin and growth hormone secretion, and on mammary nucleic acid content in C3H/Bi mice. J. Natl. Cancer Inst., 52, 189-191.
22. Spike, R.C., Johnston, H.S., McGadey, J., Moore, M.R., Thompson, G.G and Payne, A.P. (1985): Quantitative studies on the effects of hormones on structure and porphyrin biosynthesis in the Harderian gland of the female golden hamster. I. The effects of ovariectomy and androgen administration. J. Anat., 142, 59-72.
23. Strum, J.M and Shear, C.R. (1982): Constant light exposure induces damage and squamous metaplasia in Harderian glands of albino mice. Tissue Cell, 14, 149-161.
24. Thiessen, D.D., Clancy, A and Goodwin, M. (1976): Harderian gland pheromone in the Mongolian gerbil. J. Chem. Ecol., 2, 231-238.
25. Thiessen, D.D and Kittrell, E.M. (1980): The Harderian gland and the thermoregulation in the gerbil. Physiol. Behav., 24, 417-424.
26. Ulrich, R., Yuwiler, A., Geller, E and Wetterberg, L. (1974): Effects of sex hormones and environmental lighting on rat Harderian gland porphyrin. J. Endocrinology, 63, 99-102.
27. Watanabe, M. (1980): An autoradiographic, biochemical, and morphological study of the Harderian gland of the mouse. J. Morphol., 163, 349-365.
28. Welsch, C.W and Gribler, C. (1973): Prophylaxis of spontaneously developing mammary carcinoma in C3H/HeJ female mice by suppression of prolactin. Cancer Res., 33, 2939-2946.
29. Wetterberg, L., Geller, E and Yuwiler, A. (1970a): Harderian gland: an extraretinal photoreceptor influencing the pineal gland in neonatal rats. Science, 167, 884-885.
30. Wetterberg, L., Yuwiler, A., Geller, E and Schapiro, S. (1970b): Harderian glands: Development and influence of early hormonal treatment on porphyrin content. Science, 168, 996-998.
31. Wetterberg, L., Nystrom, B and Nilsson, B. (1972): Effect of lighting conditions on the porphyrin content and morphology of the Harderian gland and on uterine morphology in the golden hamster. Experientia, 28, 1084-1085.
32. Yanai, R and Nagasawa, H. (1970): Suppression of mammary hyperplastic nodule formation and pituitary prolactin secretion in mice induced by ergocornine or 2-brom- α - ergocryptine. J. Natl. Cancer Inst., 45, 1105-1112.
33. Yanai, R and Nagasawa, H. (1972): Inhibition of mammary tumorigenesis by ergot alkaloids and promotion of mammary tumorigenesis by pituitary isografts in adeno-ovariectomized mice. J. Natl. Cancer Inst., 48, 715-719.