The induction of operational tolerance is not prevented by simultaneous administration of cyclosporin A1

Transplant International

Volumn 10, Issue 4, 1997, Pages 293-298

  Hamano, Kimikazu ^a   Ito, Hiroshi ^a   Bushell, Andrew ^b   Wood, Kathryn J ^b   Esato, Kensuke ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Anti CD4, cyclosporin, tolerance; Cyclosporin, heart transplantation, mouse; Heart transplantation, cyclosporin, mouse; Tolerance, anti CD4, cyclosporin

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; OKT 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; CYCLOSPORINE; HEART TRANSPLANTATION; IMMUNE TOLERANCE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; TRANSPLANTATION, HOMOLOGOUS;

EID: 0030879109     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001470050060     Document Type: Article

References (27)

1. Alters SE, Shizuru JA, Ackerman J, Grossman D, Seydel KB, Fathman CG (1991) Anti-CD4 mediates clonal anergy during transplantation tolerance induction. J Exp Med 173: 491-494
2. Boiling SE Lin H, Wei R, Linsley P, Turka L (1994) The effect of combination cyclosporine and CTLA4-Ig therapy on cardiac allograft survival. J Surg Res 57: 60-64
3. Bushell A, Morris PJ, Wood KJ (1995) Transplantation tolerance induced by antigen pretreatment and depleting anti-CD4 antibody depends on CD4 + T cell regulation during the induction phase of the response. Eur J Immunol 25: 2643-2649
4. Chen ZK, Cobbold SP, Waldmann H, Metcalfe S (1996) Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation 62:1200-1206
5. + T cell subset. Transplantation 41: 634-639
6. Corry RJ, Winn HJ, Russell PS (1973) Primarily vascularized allografts of hearts in mice: the role of H-2D, H-2 K, and non H-2 antigens in rejection. Transplantation 16: 343-350
7. Cosimi AB, Delmonico FL, Wright KJ, Wee S, Preffer FI, Jolliffe LK, Colvin RB (1990) Prolonged survival of non-human primate renal allograft recipients treated with only anti-CD4 monoclonal antibody. Surgery 108: 406-414
8. + T cells. Transplantation 54: 483-490
9. Hamano K, Rawsthorne M, Bushell A, Morris PJ, Wood KJ (1995) Donor microchimerism is not responsible for the maintenance of tolerance to donor alloantigens in recipients tolerant of cardiac allografts. Transplant Proc 27: 151
10. Isobe M, Yagita H, Okumura K (1992) Specific acceptance of cardiac allografts after treatment with antibodies to ICAM-1 and LFA-1. Science 255: 1125-1127
11. Kuziel WA, Greene WC (1990) Interleukin-2 and the IL-2 receptor: new insights into structure and function. J Invest Dermatol 94: 27S-32S
12. Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, Winn KJ, Pearson TC (1996) Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381: 434-438
13. Madsen JC, Peugh WN, Wood KJ, Morris PJ (1987) The effect of anti-L3T4 monoclonal antibody treatment on first set rejection of murine cardiac allografts. Transplantation 44: 849-852
14. Mottram PL, Mirisklavos A, Dumble LJ, Clunie GJA (1990) T suppressor cells induced by transfusions and cyclosporine. Studies in the murine cardiac allograft model. Transplantation 50: 1033-1037
15. Opelz G (1995) Efficacy of rejection prophylaxis with OKT3 in renal transplantation. Collaborative Transplant Study. Transplantation 60: 1220-1224
16. Pearson TC, Madsen JC, Larsen CP, Morris PJ, Wood KJ (1992) Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation 54: 475-483
17. Pearson TC, Darby CR, Bushell AR, Morris PJ, Wood KJ (1993) The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the marine model. Transplantation 55: 361-367
18. Qin S, Cobbold S, Tighe H, Benjamin R, Waldmann H (1987) CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur J Immunol 17: 1159-1165
19. Qin S, Cobbold SP, Pope H, Elliott J, Kioussis D, Davies J, Waldmann H (1993) "Infectious" transplantation tolerance. Science 259: 974-977
20. Sano Shiba K, Kanaamori K, Harada T, Nakao M, Nakajima K, Kodaira T, Nakagawa H (1985) A cause of discrepancy between values for urinary protein as assayed by the coomassie brilliant blue G-250 method and the sulfosalicylic acid method. Clin Chem 31: 1215-1218
21. Schreiber SL, Crabtree GR (1992) The mechanism of action of cyclosporin A and FK506. Immunol Today 13: 136-142
22. Schwartz RH (1992) Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065-1068
23. - T cells in the presence of a non depleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J Exp Med 182: 5-13
24. Superina RA, Peugh WN, Wood KJ, Morris PJ (1986) Assessment of primarily vascularised cardiac allografts in mice. Transplantation 42: 226-227
25. Tilney NL, Padberg WM, Lord RHH, Araneda D, Strom TB, Kupiec-Weglinski JW (1988) Synergy between sub-therapeutic doses of cyclosporine and immunobiological manipulations in rat heart craft recipients. Transplantation 46: 122S-128S
26. Ueda H, Hancock WW, Cheung Y, Diamantstein T, Tilney N, Kupiec-Weglinski JW (1990) The mechanism of synergistic interaction between anti-interleukin 2 receptor monoclonal antibody and cyclosporine therapy in rat recipients of organ allografts. Transplantation 50: 545-550
27. Ueda H, Cheung Y, Masetti P, Diaco M, Martin M, Kupiec- Weglinski JW, Tilney NL (1991) Synergy between cyclosporine and anti-IL-2 receptor monoclonal antibodies in rats. Functional studies of heart and kidney allografts. Transplantation 52: 437-442