Design and mechanism of action of a novel cytotoxic 1,2,3-triazene-containing heterocycle, 3,5-dimethyl-pyrido-1,2,3,5-tetrazepin-4-one (PYRZ), in the human epithelial ovarian cancer cell line NIH:OVCAR-3 in vitro

British Journal of Cancer

Volumn 76, Issue 4, 1997, Pages 467-473

  Jean Claude, B J ^a   Mustafa, A ^a   Cetateanu, N D ^a   Damian, Z ^a   De Marte, J ^a   Yen, R ^a   Vasilescu, D ^a   Chan, T H ^a   Leyland Jones, B ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Cell cycle arrest; DNA damage; OVCAR 3 cells; Tetrazepinones

Indexed keywords

1,2,3 TRIAZINE DERIVATIVE; 3,5 DIMETHYLPYRIDO 1,2,3,5 TETRAZEPIN 4 ONE; ALKYLATING AGENT; CYTOTOXIC AGENT; DNA; DNA FRAGMENT; PROTEIN; RNA; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA ALKYLATION; DNA DEGRADATION; DNA SEQUENCE; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; KINETICS; LEUKEMIA L 1210; MITOSIS INHIBITION; OVARY CANCER; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUCROSE DENSITY GRADIENT CENTRIFUGATION;

EID: 0030878244     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.411     Document Type: Article

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