Modulation of soluble and membrane-bound TNF-induced phenotypic and functional changes of human brain microvascular endothelial cells by recombinant TNF binding protein I

Journal of Neuroimmunology

Volumn 77, Issue 1, 1997, Pages 107-115

  Lou, J ^a   Ythier, A ^b   Burger, D ^c   Zheng, L ^a   Juillard, P ^a   Lucas, R ^a   Dayer, J M ^c   Grau, G E ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b Serono International SA   (Switzerland)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Adhesion molecules; Brain microvascular endothelial cells; Cytoadherence; Cytotoxicity; TNF; TNF binding protein I

Indexed keywords

CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR BINDING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; BRAIN; CELL ADHESION; CENTRAL NERVOUS SYSTEM DISEASE; CONCENTRATION RESPONSE; CYTOTOXICITY; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE ADHERENCE; MICROVASCULATURE; PHENOTYPE; PRIORITY JOURNAL;

BRAIN; BRAIN CHEMISTRY; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; E-SELECTIN; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; INTERLEUKIN-8; LEUKOCYTE ADHERENCE INHIBITION TEST; MEMBRANE PROTEINS; MICROCIRCULATION; PHENOTYPE; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECOMBINANT PROTEINS; SOLUBILITY; TUMOR NECROSIS FACTOR DECOY RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0030876809     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00067-2     Document Type: Article

References (51)

1. Aderka, D., Engelmann, H., Hornik, V., Skornick, Y., Levo, Y., Wallach, D., Kushtai, G., 1991. Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. Cancer Res. 51, 5602-5607.
2. Aderka, D., Engelmann, H., Maor, Y., Brakebusch, C., Wallach, D., 1992. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J. Exp. Med. 175, 323-329.
3. Aggarwal, B.B., Eessalu, T.E., Hass, P.E., 1985. Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon. Nature 318, 665-667.
4. Belloni, P.N., Carney, D.H., Nicolson, G.L., 1992. Organ-derived microvessel endothelial cells exhibit differential responsiveness to thrombin and other growth factors. Microvascular Res. 43, 20-45.
5. Bemelmans, M.H.A., Gouma, D.J., Buurman, W.A., 1993. LPS-induced sTNF-receptor release in vivo in a murine model: Investigation of the role of tumor necrosis factor, IL-1 leukemia inhibiting factor and IFN-gamma. J. Immunol. 151, 5554-5562.
6. Bradley, J.R., Thiru, S., Pober, J.S., 1995. Disparate localization of 55 kd and 75 kd tumor necrosis factor receptors in human endothelial cells. Am. J. Pathol. 146, 27-32.
7. Brockhaus, M., Schoenfeld, H.J., Schlaeger, E.J., Hunziker, W., Lesslauer, W., Loetscher, H., 1990. Identification of 2 types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 87, 3127-3131.
8. Cannella, B., Raine, C.S., 1995. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann. Neurol. 37, 424-435.
9. Corti, A., Fassina, G., Marcucci, F., Barbanti, E., Cassani, G., 1992. Oligomeric tumour necrosis factor alpha slowly converts into inactive forms at bioactive levels. Biochem. J. 284, 905-910.
10. Degroote, D., Grau, G.E., Dehart, I., Franchimont, P., 1993. Stabilisation of functional tumor necrosis factor-alpha by its soluble TNF receptors. Eur. Cytokine Netw. 4, 359-362.
11. Dorge, S.E., Rouxlombard, P., Dayer, J.M., Koch, K.M., Frei, U., Lonnemann, G., 1994. Plasma levels of tumor necrosis factor (TNF) and soluble TNF receptors in kidney transplant recipients. Transplantation 58, 1000-1008.
12. Elices, M.J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M.E., Lobb, R.R., 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4 fibronectin binding site. Cell 60, 577-584.
13. Engelmann, H., Aderka, D., Rubinstein, M., Rotman, D., Wallach, D., 1989. A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity. J. Biol. Chem. 264, 11974-11980.
14. Engelmann, H., Novick, D., Wallach, D., 1990. 2 tumor necrosis factor-binding proteins purified from human urine: Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. J. Biol. Chem. 265, 1531-1536.
15. Espevik, T., Nissen-Meyer, K., 1986. A highly sensitive cell line, WEHI 164-clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Methods 95, 99-103.
16. Gehr, G., Braun, T., Lesslauer, W., 1992. Cytokines, receptors and inhibitors. Clin. Investigator. 70, 64-69.
17. Grau, G.E., Lou, J., 1993. TNF in vascular pathology: Importance of platelet-endothelium interaction. Res. Immunol. 144, 355-363.
18. Grau, G.E., Fajardo, L.F., Piguet, P.F., Allet, B., Lambert, P.H., Vassalli, P., 1987. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237, 1210-1212.
19. Hale, K.K., Smith, C.G., Baker, S.L., Vanderslice, R.W., Squires, C.H., Gleason, T.M., Tucker, D.D., Kohno, T., Russell, D.A., 1995. Multifunctional regulation of the biological effects of TNF-alpha by the soluble type I and type II TNF receptors. Cytokine 7, 26-38.
20. Heilig, B., Fiehn, C., Brockhaus, M., Gallati, H., Pezzutto, A., Hunstein, W., 1993. Evaluation of soluble tumor necrosis factor (TNF) receptors and TNF receptor antibodies in patients with systemic lupus erythematodes, progressive systemic sclerosis and mixed connective tissue disease. J. Clin. Immunol. 13, 321-328.
21. Hofman, F.M., Hinton, D.R., Johnson, K., Merrill, J.E., 1989. Tumor necrosis factor identified in multiple sclerosis brain. J. Exp. Med. 170, 607-612.
22. Hohmann, H.P., Brockhaus, M., Baeuerle, P.A., Remy, R., Kolbeck, R., Vanloon, A.P.G.M., 1990. Expression of the type-A and type-B tumor necrosis factor (TNF) receptors is independently regulated and both receptors mediate activation of the transcription factor NF-kappaB-TNF alpha is not needed for induction of a biological effect via TNF receptors. J. Biol. Chem. 265, 22409-22417.
23. Jin, H.K., Yang, R.H., Marsters, S.A., Bunting, S.A., Wurm, F.M., Chamow, S.M., Ashkenazi, A., 1994. Protection against rat endotoxic shock by p55 tumor necrosis factor (TNF) receptor immunoadhesin: Comparison with anti-TNF monoclonal antibody. J. Infect. Dis. 170, 1323-1326.
24. Kern, P., Hemmer, C.J., Gallati, H., Neifer, S., Kremsner, P., Dietrich, M., Porzsolt, F., 1992. Soluble tumor necrosis factor receptors correlated with parasitemia and disease severity in human malaria. J. Infect. Dis. 166, 930-934.
25. Kern, W.V., Engel, A., Schieffer, S., Prummer, O., Kern, P., 1993. Circulating tumor necrosis factor alpha (TNF), soluble TNF receptors and interleukin-6 in human subacute bacterial endocarditis. Infect. Immun. 61, 5413-5416.
26. Kinkhabwala, M., Sehajpal, P., Skolnik, E., Smith, D., Sharma, V.K., Vlassara, H., Cerami, A., Suthanthiran, M., 1990. A novel addition to the T-cell repertory: Cell surface expression of tumor necrosis factor cachectin by activated normal human T-cells. J. Exp. Med. 171, 941-946.
27. Lantz, M., Gullberg, U., Nilsson, E., Olsson, I., 1990. Characterization in vitro of a human tumor necrosis factor-Binding protein: A soluble form of a tumor necrosis factor receptor. J. Clin. Invest. 86, 1396-1402.
28. Lesslauer, W., Tabuchi, H., Gentz, R., Brockhaus, M., Schlaeger, E.J., Grau, G.E., Piguet, P.F., Pointaire, P., Vassalli, P., Loetscher, H., 1991. Recombinant soluble TNF receptor proteins protect mice from LPS-induced lethality. Eur. J. Immunol. 21, 2883-2886.
29. Loetscher, H., Gentz, R., Zulauf, M., Lustig, A., Tabuchi, H., Schlaeger, E.J., Brockhaus, M., Gallati, H., Manneberg, M., Lesslauer, W., 1991. Recombinant 55 kDa tumor necrosis factor (TNF) receptor: Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity. J. Biol. Chem. 266, 18324-18329.
30. Lou, J., Dayer, J.M., Grau, E.G., Burger, D., 1996. Direct cell-cell contact with stimulated T-lymphocytes induced the expression of cell adhesion molecules and cytokines by human brain microvascular endothelial cells. Eur. J. Immunol. 26, 1307-1313.
31. Lou, J., Chofflon, M., Juillard, C., Donati, Y., Mili, N., Siegrist, C.N., Grau, E.G., 1997. Brain microvascular endothelial cells and leukocytes derived from patients with multiple sclerosis exhibit increased adhesion capacity. Neuroreport 8, 629-633.
32. Luettig, B., Decker, T., Lohmannmatthes, M.L., 1989. Evidence for the existence of 2 forms of membrane tumor necrosis factor: An integral protein and a molecule attached to its receptor. J. Immunol. 143, 4034-4038.
33. Mackay, F., Loetscher, H., Stueber, D., Gehr, G., Lesslauer, W., 1993. Tumor necrosis factor-alpha (TNF-alpha): Induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. J. Exp. Med. 177, 1277-1286.
34. Mantovani, A., Bussolino, F., Dejana, E., 1992. Cytokine regulation of endothelial cell function. FASEB J 6, 2591-2599.
35. Peetre, C., Thyssel, H., Grubb, A., Olsson, I., 1988. A tumor necrosis factor binding protein is present in human biological fluids. Eur. J. Haematol. 41, 414-419.
36. Pober, J.S., Hughes, C.C.W., Savage, C.O.S., Schoen, F.J., Libby, P., 1991. Endothelial cell-lymphocyte interactions. Cell. Cytokine Networks Tissue Immun. 11, 183-188.
37. Pober, J.S., Cotran, R.S., 1990. The role of endothelial cells in inflammation. Transplantation 50, 537-544.
38. Porta, J., Carota, A., Pizzolato, G.P., Wildi, E., Widmer, M.C., Margairaz, C., Grau, G.E., 1993. Immunopathological changes in human cerebral malaria. Clin. Neuropathol. 12, 142-146.
39. Powell, M.B., Mitchell, D., Lederman, J., Buckmeier, J., Zamvil, S.S., Graham, M., Ruddle, N.H., Steinman, L., 1990. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T-cell clones correlates with encephalitogenicity. Int. Immunol. 2, 539-544.
40. Rupnick, M.A., Carey, A., Williams, S.K., 1988. Phenotypic diversity in cultured cerebral microvascular endothelial cells. In Vitro Cell Dev. Biol. 24, 435-444.
41. Seckinger, P., Isaaz, S., Dayer, J.M., 1989. Purification and biologic characterization of a specific tumor necrosis factor-alpha inhibitor. J. Biol. Chem. 264, 11966-11973.
42. Selmaj, K., Raine, C.S., Cannella, B., Brosnan, C.F., 1991. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J. Clin. Invest. 87, 949-954.
43. Sharief, M.K., Thompson, E.J., 1992. In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis. J. Neuroimmunol. 38, 27-33.
44. Slowik, M.R., Deluca, L.G., Fiers, W., Pober, J.S., 1993. Tumor necrosis factor activates human endothelial cells through the p55-tumor necrosis factor receptor but the p75-receptor contributes to activation at low tumor necrosis factor concentration. Am. J. Pathol. 143, 1724-1730.
45. Smith, C.W., Marlin, S.D., Rothlein, R., Toman, C., Anderson, D.C., 1989. Cooperative interactions of LFA-1 and MAC-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J. Clin. Invest. 83, 2008-2017.
46. Sobel, R.A., Mitchell, M.E., Fondren, G., 1990. Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am. J. Pathol. 136, 1309-1316.
47. Tartaglia, L.A., Weber, R.F., Figari, I.S., Reynolds, C., Palladino, M.A., Goeddel, D.V., 1991. The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc. Natl. Acad. Sci. USA 88, 9292-9296.
48. Tilg, H., Vogel, W., Dinarello, C.A., 1995. Interferon-alpha induces circulating tumor necrosis factor receptor p55 in humans. Blood 85, 433-435.
49. Turner, G.D.H., Morrison, H., Jones, M., Davis, T.M.E., Looareesuwan, S., Buley, I.D., Gatter, K.C., Newbold, C.I., Pukritayakamee, S., Nagachinta, B., White, N.J., Berendt, A.R., 1994. An immunohistochemical study of pathology of fatal malaria evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am. J. Pathol. 145, 1057-1069.
50. Vanderpoll, T., Vanleenen, D., Vondermohlen, M., Levi, M., Tencate, H., Gallati, H., Tencate, J.W., Vandeventer, J.H., 1993. Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia. J. Infect. Dis. 168, 955-960.
51. Ythier, A., Gascon, M.P., Juillard, P., Vesin, C., Wallach, D., Grau, G.E., 1993. Protective effect of natural TNF-binding protein on human TNF-induced toxicity in mice. Cytokine 5, 459-462.