Gas chromatographic-mass spectrometric identification and quantitation of benzyl alcohol from human serum and postmortem blood after derivatization with 4-carbethoxy hexafluorobutyryl chloride: A novel derivative

Journal of Forensic Sciences

Volumn 42, Issue 4, 1997, Pages 697-700

  Dasgupta, Amitava ^a,b   Steinagel, Geraldine ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF NEW MEXICO HOSPITAL   (United States)

Author keywords

4 carbethoxyhexafluorobutyryl derivative; Benzyl alcohol; Forensic science; Forensic toxicology; Gas chromatography mass spectrometry

Indexed keywords

3,4 XYLENOL; 4 CARBETHOXYHEXAFLUOROBUTYRYL CHLORIDE; BENZYL ALCOHOL; CHLOROFORM; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; AUTOPSY; BLOOD LEVEL; CONTROLLED STUDY; DERIVATIZATION; FORENSIC IDENTIFICATION; GAS CHROMATOGRAPHY; HEMOLYSIS; HUMAN; HUMAN TISSUE; INTOXICATION; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SERUM;

EID: 0030876576     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: 10.1520/jfs14186j     Document Type: Article

References (9)

1. Jardine DS, Rogers J. Relationship of benzyl alcohol to kernictenis intraventricular hemorrhage, and mortality in preterm infants. Pediatrics 1989;83:153-60.
2. Hiller JL, Benda GI, Rahatzad M, Allen JR, Culver DH, Carlson CV, et al. Benzyl alcohol toxicity: Impact on mortality and intraventricular hemorrhage among very low birth weight infants. Pediatrics 1986;77:500-6.
3. Brown WJ, Buist NRM, Gipson HTC, Huston R, Kennaway NG. Fatal benzyl alcohol poisoning in a neonatal intensive care unit. Lancet 1982;1:1250.
4. Gershanik J, Boecler H, Ensley H, McCloskey S, George W. The gasping syndrome and benzyl alcohol poisoning. N Eng J Med 1982;307:1384-8.
5. Schileifer JH, Carson TL. Toxicity of benzyl alcohol preservatives. J Am Vet Med Assoc 1982;61:853 (letter).
6. Tan HI, Manning MA, Hann M, Tan H. Determination of benzyl alcohol and its metabolite in plasma by reverse phase high performance liquid chromatography. J Chromatogr 1991;568:145-55.
7. Block JH, Levine HL. Rapid and sensitive high-pressure liquid chromatography technique for detecting impurities in benzaldehyde USP. J Chromatogr 1978;166:313-5.
8. Rego A, Nelson B. Simultaneous determination of hydrocortisone and benzyl alcohol in pharmaceutical formulations by reverse phase high pressure liquid chromatography. J Pharmaceutical Sci 1982;71:1219-23.
9. Czarny RJ, Hornbeck CL. Quantitation of methamphetamine and amphetamine in urine by capillary GC/MS: Part II. Derivatization with 4-carbethoxyhexafluorobutyryl chloride. J Anal Toxicol 1989;13:257-62.