Protection of rat spinal cord from ischemia with dextrorphan and cycloheximide: Effects on necrosis and apoptosis

Journal of Thoracic and Cardiovascular Surgery

Volumn 114, Issue 4, 1997, Pages 609-618

  Kato, H ^a   Kanellopoulos, G K ^a   Matsuo, S ^a   Wu, Y J ^a   Jacquin, M F ^a   Hsu, C Y ^a   Choi, D W ^a   Kouchoukos, N T ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; DEXTRORPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL POPULATION; CELL PROTECTION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG EFFECT; EMBRYO DEVELOPMENT; NECROSIS; NONHUMAN; PARAPLEGIA; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA;

EID: 0030876471     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(97)70051-5     Document Type: Article

References (29)

1. LG Svensson ES Crawford KR Hess JS Coselli HJ Safi Experience with 1509 patients undergoing thoracoabdominal aortic operations J Vasc Surg 17 1993 357 370
2. NT Kouchoukos Spinal cord ischemic injury: is it preventable? Semin Thorac Cardiovasc Surg 3 1991 323 328
3. H Benveniste J Drejer A Schousboe NH Diemer Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis J Neurochem 43 1984 1369 1374
4. M Marsala LS Sorkin TL Yaksh Transient spinal ischemia in rat: characterization of spinal cord blood flow, extracellular amino acid release, and concurrent histopathological damage J Cereb Blood Flow Metab 14 1994 604 614
5. DW Choi Glutamate neurotoxicity and diseases of the nervous system Neuron 1 1988 623 634
6. RP Simon JH Swan T Griffiths BS Meldrum Blockade of N -methyl-D-aspartate receptors may protect against ischemic damage in the brain Science 226 1984 850 852
7. F Follis K Miller OU Scremin S Pett R Kessler J Wernly NMDA receptor blockade and spinal cord ischemia due to aortic crossclamping in the rat model Can J Neurol Sci 21 1994 227 232
8. M Linnik RH Zobrist MD Hatfield Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats Stroke 24 1993 2002 2009
9. AH Wyllie JFR Kerr AR Currie Cell death: the significance of apoptosis Int Rev Cytol 68 1980 251 306
10. AH Wyllie RG Morris AL Smith D Dunlop Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis J Pathol 142 1984 67 77
11. XZ Liu XM Xu R Hu Effect of cycloheximide on DNA breakdown, tissue loss, and behavioral outcome after spinal cord impact injury Abst Soc Neurosci 22 1996 1185
12. DW Choi S Peter V Viseskul Dextrorphan and levorphanol selectively block N -methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons J Pharmacol Exp Ther 242 1987 713 720
13. C Du R Hu CY Hsu DW Choi Dextrorphan reduces infarct volume, vascular injury, and brain edema after ischemic brain injury J Neurotrauma 13 1996 215 222
14. AI Faden JA Ellison LJ Noble Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury Eur J Pharmacol 175 1990 165 174
15. A Coston M Laville P Baud B Bussel M Jalfre Aortic occlusion by a balloon catheter: a method to induce hind limb rigidity in rats Physiol Behav 30 1983 967 969
16. Y Gavrieli Y Sherman SA Ben-Sasson Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation J Cell Biol 119 1992 493 501
17. J Deshpande K Bergstedt T Lindén H Kalimo T Wieloch Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death Exp Brain Res 88 1992 91 105
18. GH Sloane-Stanley RA Chase Intrathecal injections in rats by percutaneous lumbar puncture J Pharm Pharmacol 33 1981 480 482
19. JH Garcia K-F Liu K-L Ho Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex Stroke 26 1995 636 643
20. M van Lookeren Campagne PJ Lucassen JP Vermeulen R Balázs NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain Eur J Neurosci 7 1995 1627 1640
21. JP MacManus IE Hill E Preston I Rasquinha T Walker AM Buchan Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats J Cereb Blood Flow Metab 15 1995 728 737
22. BJ Gwag JY Koh JA DeMaro HS Ying M Jacquin DW Choi Slowly-triggered excitotoxicity occurs by necrosis in cortical cultures Neuroscience 77 1997 393 401
23. H Pollard C Charriaut-Marlangne S Cantagrel Kainate-induced apoptotic cell death in hippocampal neurons Neuroscience 63 1994 7 18
24. M Ankarcrona JM Dypbukt E Bonfoco Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function Neuron 15 1995 961 973
25. A Buchan WA Pulsinelli Hypothermia but not the N -methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia J Neurosci 10 1990 311 316
26. M Kiessling Y Xie B Ullrich R Thilmann Are the neuroprotective effects of the protein synthesis inhibitor cycloheximide due to prevention of apoptosis? (abstract) J Cereb Blood Flow Metab 11 suppl 2 1991 S357
27. CS Robertson RG Grossman Protection against spinal cord ischemia with insulin-induced hypoglycemia J Neurosurg 67 1987 739 744
28. DR LeMay AC Lu GB Zelenoch LG D'Alecy Insulin administration protects from paraplegia in the rat aortic occlusion model J Surg Res 44 1988 352 358
29. C Du R Hu CA Csernansky XZ Liu CY Hsu DW Choi Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia Brain Res 718 1996 233 236