Trp64Arg substitution in the β3-adrenergic receptor does not relate to body weight in healthy, premenopausal women

International Journal of Obesity

Volumn 21, Issue 9, 1997, Pages 826-829

  Moriarty, M ^a   Wing, R R ^a,b   Kuller, L H ^a   Ferrell, R E ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Obesity; Trp64arg substitution; 3 adrenergic receptor

Indexed keywords

AMINO ACID; ARGININE; BETA 3 ADRENERGIC RECEPTOR; TRYPTOPHAN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BODY MASS; BODY WEIGHT; FEMALE; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; MEASUREMENT; NORMAL HUMAN; PHENOTYPE; PREMENOPAUSE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

EID: 0030876394     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800489     Document Type: Article

References (28)

1. Bouchard C. Genetics and the metabolic syndrome. Int J Obes 1995; 19 (Suppl. 1): S52-S59.
2. Ferrell RE. Obesity: choosing genetic approaches from a mixed menu. Hum Biol 1995; 65: 967-975.
3. 3-adrenoceptors. Med Res Rev 1993; 13(6): 663-729.
4. Muzzin P, Revelli JP, Kuhne F, Gocayne JD, McCombie WR, Venter JC, Giacobino JP, Fraser CM. An adipose tissue-specific β-adrenergic receptor: molecular cloning and down-regulation in obesity. J Biol Chem 1991; 266(35): 24053-24058.
5. 3-adrenergic-receptor gene. N Engl J Med 1995; 333(6): 343-347.
6. 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 1995; 333(6): 348-351.
7. Clément K, Vaisse C, Basdevant A, Manning BSJ, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD. Genetic variation in the β-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995; 333(6): 352-354.
8. 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun 1995; 215(2): 555-560.
9. 3-adrenergic receptor gene in normal weight and obese subjects. Diabetologia 1996; 39: 857-860.
10. 3-adrenergic receptor gene Trp64Arg mutation is overrepresented in obese women: effects on weight, BMI, abdominal fat, blood pressure, and reproductive history in an elderly Australian population. Diabetes 1996; 45: 1358-1363.
11. Gagnon J, Mauriège P, Roy S, Sjöstròm D, Chagnon YC, Dionne FT, Oppert JM, Pérusse L, Sjöström L, Bouchard C. The Trp64Arg mutation of the β-adrenergic receptor gene has no effect on obesity phenotypes in the Quebec Family Study and Swedish Obese Subjects cohorts: the Trp64Arg mutation of ADRB3 gene and obesity. J Clin Invest 1996; 98(9): 2086-2093.
12. 3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia 1996; 39: 349-352.
13. 3-adrenergic receptor gene. Diabetes 1996; 45: 1115-1120.
14. 3-adrenoceptor genes in obese people submitted to a low calorie diet. Int J Obes 1996; 20: 1051-1054.
15. 3-adrenergic receptor gene on weight gain in morbid obesity. Int J Obes 1996; 20: 1062-1066.
16. 3-adrenergic receptor gene in morbid obesity. Int J Obes 1996; 20: 1055-1061.
17. Saiki RK, Gelfand DH, Stoffel S, Scharf SS, Higuchi R, Horn GT, Mullis KB, Erlich HA. Primer-directed amplification of DNA with a thermostable DNA polymerase. Science 1988; 239: 487-491.
18. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20: 470-475.
19. Warnick GR, Albers JJ. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res 1978; 19: 65-76.
20. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 1973; 19: 476-482.
21. Bonder RJL, Meade DC. Evaluation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides in the hexokinase method for determining glucose in serum. Clin Chem 1974; 20: 586.
22. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
23. Jackson AS, Pollock ML, Ward A. Generalized equations for predicting body density of women. Med Sci Sport Exerc 1980; 12: 175-182.
24. Garrow JS. Zero-muddler for unprejudiced sphygmomanometry. Lancet 1963; 2: 1205.
25. 3-adrenergic receptor gene affects basal metabolic rate in obese Finns. Diabetes 1997; 46: 77-80.
26. 3-adrenergic receptor gene in Japanese subjects. Metab 1997; 46(2): 199-202.
27. Laakso M. How good a marker is insulin level for insulin resistance? Am J Epidemiol 1993; 137: 959-965.
28. 3-adrenoceptor gene of doubtful significance for obesity and insulin resistance. Lancet 1996; 348: 698-699.