Quantitative morphology of the rat kidney during diabetes mellitus and insulin treatment

Diabetologia

Volumn 40, Issue 7, 1997, Pages 802-809

  Rasch, R ^a   Dorup J ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Diabetes mellitus; Diabetic nephropathy; Experimental; Kidney; Morphometry

Indexed keywords

INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; FEMALE; GLOMERULUS; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN TREATMENT; KIDNEY; KIDNEY MASS; MORPHOLOGY; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CONNECTIVE TISSUE; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; HYPERGLYCEMIA; INSULIN; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; KIDNEY TUBULES, PROXIMAL; ORGAN SIZE; RATS; RATS, WISTAR;

EID: 0030876055     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050752     Document Type: Article

References (39)

1. Seyer-Hansen K (1977) Renal hypertrophy in experimental diabetes: relation to severity of diabetes. Diabetologia 13: 141-143
2. Seyer-Hansen K (1978) Renal hypertrophy in experimental diabetes: a comparison to compensatory hypertrophy. Diabetologia 14: 325-328
3. Seyer-Hansen K (1987) Renal hypertrophy in experimental diabetes: some functional aspects. J Diabetic Complications 1: 7-10
4. Seyer-Hansen K, Hansen J, Gundersen HJ (1980) Renal hypertrophy in experimental diabetes. A morphometric study. Diabetologia 18: 501-505
5. Rasch R, Norgaard JO (1983) Renal enlargement: comparative autoradiographic studies of 3H-thymidine uptake in diabetic and uninephrectomized rats. Diabetologia 25: 280-287
6. Gotzsche O, Gundersen HJ, Osterby R (1981) Irreversibility of glomerular basement membrane accumulation despite reversibility of renal hypertrophy with islet transplantation in early experimental diabetes. Diabetes 30: 481-485
7. Maunsbach AB (1966) The influence of different fixatives and fixation methods on the ultrastructure of rat kidney proximal tubule cells. I. Comparison of different perfusion fixation methods and of glutaraldehyde, formaldehyde and osmium tetroxide fixatives. J Ultrastruct Res 15: 242-282
8. Baddeley AJ, Gundersen HJ, Cruz-Orive LM (1986) Estimation of surface area from vertical sections. J Microsc 142: 259-276
9. Mayhew TM, Reith A (1988) Introducing basic principles and methods of stereology and morphometry. In: Reith A, Mayhew TM (eds) Stereology and morphometry in electron microscopy. Problems and solutions. Hemisphere Publishing Corporation, New York, pp 1-12
10. Bohman SO, Maunsbach AB (1970) Effects on tissue fine structure of variations in colloid osmotic pressure of glutaraldehyde fixatives. J Ultrastruct Res 30: 195-208
11. Weibel ER (1973) Stereological techniques for electron microscopic morphometry. In: Hayat MA (ed) Principles and techniques for electron microscopy, vol 3. Van Nostrand Reinhold, New York, pp 239-296
12. Mogensen CE, Andersen MJ (1973) Increased kidney size and glomerular filtration rate in early juvenile diabetes. Diabetes 22: 706-712
13. Murray BM, Campos SP, Schoenl M, MacGillivray MH (1993) Effect of dietary protein intake on renal growth: possible role of insulin- like growth factor-I [see comments]. J Lab Clin Med 122: 677-685
14. Tuttle KR, Bruton JL, Perusek MC, Lancaster JL, Kopp DT, DeFronzo RA (1991) Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus. N Engl J Med 324: 1626-1632
15. Christensen CK, Christiansen JS, Christensen T, Hermansen K, Mogensen CE (1986) The effect of six months continuous subcutaneous insulin infusion on kidney function and size in insulin-dependent diabetics. Diabetic Med 3: 29-32
16. Mogensen CE, Andersen MJ (1975) Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: normalization by insulin-treatment. Diabetologia 11: 221-224
17. Wiseman MJ, Saunders AJ, Keen H, Viberti GC (1985) Effect of blood glucose control on increased glomerular filtration rate and kidney size in insulin-dependent diabetes. N Engl J Med 312: 617-620.
18. Rasch R (1979) Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment. Kidney size and glomerular volume. Diabetologia 16: 125-128
19. Stackhouse S, Miller PL, Park SK, Meyer TW (1990) Reversal of glomerular hyperfiltration and renal hypertrophy by blood glucose normalization in diabetic rats. Diabetes 39: 989-995
20. Lundbaek K (1965) Nephropathy in diabetic subjects. In: Leibel BS, Wrenshall GA (eds) On the Nature and Treatment of Diabetes. Excerpta Media Foundation, Amsterdam, pp 436-446
21. Mogensen CE, Christensen CK, Vittinghus E (1983) The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy. Diabetes 32[Suppl 2]:64-78
22. Olsen TS (1969) Diabetic glomerulosclerosis: a comparison between human and experimental lesions. Int Rev Exp Pathol 7: 271-304
23. Rasch R (1979) Control of blood glucose levels in the streptozotocin diabetic rat using a long-acting heat-treated insulin. Diabetologia 16: 185-190
24. Steffes MW, Mauer SM (1990) Pathophysiology of renal complications. In: Rifkin H, Porte D (eds) Ellenberg and Rifkin's diabetes mellitus, theory and practice, 4th edn. Elsevier, New York Amsterdam, pp 257-263
25. Rasch R, Nyengaard JR, Flyvbjerg A (1995) The number of nuclei in glomeruli from diabetic rats. J Am Soc Nephrol 6: 1046 (Abstract)
26. Nyengaard JR, Rasch R (1993) The impact of experimental diabetes mellitus in rats on glomerular capillary number and sizes. Diabetologia 36: 189-194
27. Gundersen HJ, Seefeldt T, Osterby R (1980) Glomerular epithelial foot processes in normal man and rats. Distribution of true width and its intra- and inter-individual variation. Cell Tissue Res 205: 147-155
28. Nyengaard JR, Flyvbjerg A, Rasch R (1993) The impact of renal growth, regression and regrowth in experimental diabetes mellitus on numbers and sizes of proximal and distal tubular cells in rat kidney. Diabetologia 36:1126-1131
29. Flyvbjerg A, Bornfeldt KE, Marshall SM, Arnqvist HJ, Orskov H (1990) Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats. Diabetologia 33: 334-338
30. Flyvbjerg A, Frystyk J, Marshall SM (1990) Additive increase in kidney insulin-like growth factor I and initial renal enlargement in uninephrectomized-diabetic rats. Horm Metab Res 22: 516-520
31. Rasch R (1986) Kidney Na,K-ATPase activity in streptozotocin-diabetic rats. Scan J Clin Lab Invest 46: 59-62
32. Wald H, Scherzer P, Popovtzer MM (1986) Enhanced renal tubular ouabain-sensitive ATPase in streptozotocin diabetes mellitus. Am J Physiol 251:F164-F170
33. Maunsbach AB, Madden SC, Latta H (1962) Light and electron microscopic changes in proximal tubules of rats after administration of glucose, mannitol, sucrose, or dextran. Lab Invest 11: 421-432
34. Holck P, Rasch R (1993) Structure and segmental localization of glycogen in the diabetic rat kidney. Diabetes 42: 891-900
35. Hoyer JR, Seiler MW (1979) Pathophysiology of Tamm-Horsfall protein. Kidney Int 16: 279-289
36. Torffvit O, Agardh CD, Kjellsson B, Wieslander J (1992) Tubular secretion of Tamm-Horsfall protein in type 1 (insulin-dependent) diabetes mellitus using a simplified enzyme linked immunoassay. Clin Chim Acta 205: 31-41
37. Rasch R, Torffvit O, Bachmann S, Jensen PK, Jacobsen NO (1995) Tamm-Horsfall glycoprotein in streptozotocin diabetic rats: a study of kidney in situ hybridization, immunohistochemistry, and urinary excretion. Diabetologia 38: 525-535
38. Hession C, Decker JM, Sherblom AP et al. (1987) Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokines. Science 237: 1479-1484
39. Schwieger J, Fine LG (1990) Renal hypertrophy, growth factors, and nephropathy in diabetes mellitus. Semin Nephrol 10: 242-253