Long-acting injectable bromocriptine does not reduce relapse in alcoholics

Addiction

Volumn 92, Issue 8, 1997, Pages 969-978

  Naranjo, C A ^a   Dongier, M ^b   Bremner, K E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; BROMOCRIPTINE MESILATE; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; LONG ACTING DRUG; NEUROTRANSMITTER; PLACEBO;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CLINICAL TRIAL; CONCENTRATION LOSS; CONTROLLED CLINICAL TRIAL; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DETOXIFICATION; FATIGUE; FEMALE; HEADACHE; HUMAN; HYPOTENSION; IMPOTENCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; RANDOMIZED CONTROLLED TRIAL; RASH; RELAPSE; VERTIGO; VOMITING;

ADOLESCENT; ADULT; AGED; ALCOHOLISM; BROMOCRIPTINE; DOPAMINE ANTAGONISTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; RECURRENCE; TREATMENT FAILURE;

EID: 0030876038     PISSN: 09652140     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1360-0443.1997.tb02976.x     Document Type: Article

References (29)

1. AMIT, Z. & SMITH, B. R. (1992) Neurotransmitter systems regulating alcohol intake, in: NARANJO, C. A. & E. M. SELLERS (Eds) Novel Pharmacological Treatments for Alcoholism, pp. 161-183 (New York, Springer-Verlag).
2. NARANJO, C. A., GEORGE, S. R. & BREMNER, K. E. (1992) Novel neuropharmacological treatments of alcohol dependence, Clinical Neuropharmocology, 15 (suppl. 1, Pt A), 74A-75A.
3. WEISS, F., LORANG, M. T., BLOOM, F. E. & KOOB, G. F. (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants, Journal of Pharmacology and Experimental Therapeutics, 267, 250-258.
4. GEORGE, S. R., FAN, T., NG, G. Y. K., JUNG, S. Y., O'DOWD, B. F. & NARANJO, C. A. (1995) Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine, Journal of Pharmacology and Experimental Therapeutics, 273, 373-379.
5. MCBRIDE W. J., BODART, B., LUMENG, L. & LI, T.-K. (1995) Association between low contents of dopamine and serotonin in the nucleus accumbens and high alcohol preference, Alcoholism: Clinical and Experimental Research, 19, 1420-1422.
6. WEISS, F., MITCHINER, M., BLOOM, F. E. & KOOB, G. F. (1990) Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide, Psychopharmacology, 101, 178-186.
7. 2 receptor gene alleles in substance abuse, Archives of General Psychiatry, 49, 157-160.
8. SCHMIDT, L. G., DETTLING, M., GRAEF, K.-J. et al. (1996) Reduced dopaminergic function in alcoholics is related to severe dependence, Biological Psychiatry, 39, 193-198.
9. BORG, V. & WEINHOLDT, T. (1982) Bromocriptine in the treatment of the alcohol withdrawal syndrome, Acta Psychiatrica Scandinavica, 65, 101-111.
10. BURROUGHS, A. K., MORGAN, M. Y. & SHERLOCK, S. (1985) Double-blind controlled trial of bromocriptine, chlordiazepoxide and chlormethiazole for alcohol withdrawal symptoms, Alcohol and Alcoholism, 20, 263-271.
11. BORG, V. (1983) Bromocriptine in the prevention of alcohol abuse, Acta Psychiatrica Scandinavica, 68, 100-110.
12. DONGIER, M., VACHON, L. & SCHWARTZ, G. (1991) Bromocriptine in the treatment of alcohol dependence, Alcoholism: Clinical and Experimental Research, 15, 970-977.
13. DEROGATIS, L. R. (1977) The SCL-90 Manual I: scoring, administration and procedures for the SCL-90 (Baltimore, Clinical Psychometric Research).
14. SOBELL, L. C. & SOBELL, M. B. (1992) Timeline follow-back: a technique for assessing self-reported alcohol consumption, in: LITTEN, R. Z. & ALLEN, J. P. (Eds) Measuring Alcohol Consumption. Psychosocial and biochemical methods, pp. 41-72 (Totowa, NJ, Humana Press).
15. SELZER, M. D. (1971) The Michigan Alcoholism Screening Test: the quest for a new diagnostic instrument, American Journal of Psychiatry, 127, 1653-1659.
16. AMERICAN PSYCHIATRIC ASSOCIATION (1987) Diagnostic and Statistical Manual of Mental Disorders, third edition, revised (Washington, DC, American Psychiatric Association).
17. MONTGOMERY, S. A. & ASBERG, M. (1979) A new depression scale designed to be sensitive to change, British Journal of Psychiatry, 134, 382-389.
18. SANDOZ PHARMA LTD (1988) Parlodel LAR® Investigator's Brochure (Basle, Switzerland, Sandoz).
19. WORLD MEDICAL ASSOCIATION (Helsinki 1964, amended Tokyo 1975, Venice 1983, Hong Kong 1989) Recommendations Guiding Physicians in Biomedical Research Involving Human Subjects (Ferney-Voltaire, France).
20. SANDOZ PHARMA LTD (1993) Final Clinical and Statistical Report on a Sandoz International Multicenter Study Assessing the Tolerability, Safety and Efficacy of Parlodel® LAR in Alcoholic Patients (Basle, Switzerland, Sandoz).
21. ALTMAN, D. G. (1991) Practical Statistics for Medical Research (London, Chapman & Hall).
22. GOLDMAN, A. J. & ELWOOD, J. M. (1979) Examining survival data, Canadian Medical Association Journal, 121, 1065-1071.
23. SNEDECOR, G. W. & COCHRAN, W. G. (1980) Statistical Methods, Seventh Edition (Ames, Iowa, USA, Iowa State University Press).
24. SIEGEL, S. & CASTELLAN JR, N. J. (1988) Nonparametric Statistics for the Behavioural Sciences (New York, McGraw-Hill).
25. CUSHMAN, P. (1992) Blood and liver markers in the estimation of alcohol consumption in: LITTEN, R. Z. & ALLEN, J. P. (Eds) Measuring Alcohol Consumption - Psychosocial and biochemical methods, pp. 135-147 (Totowa, NJ, Humana Press).
26. POWELL B. J., CAMPBELL J. L., LANDON, J. F. et al., (1995) A double-blind, placebo-controlled study of nortriptyline and bromocriptine in male alcoholics subtyped by comorbid psychiatric disorders, Alcoholism: Clinical and Experimental Research, 19, 462-468.
27. VANCE, M. L., EVANS, W. S. & THORNER, M. O. (1984) Bromocriptine, Annals of Internal Medicine, 100, 78-91.
28. NARANJO, C. A., BREMNER, K. E. & LANCTO̊T, K. L. (1995) Effects of citalopram and a brief psycho-social intervention on alcohol intake, dependence and problems, Addiction, 90, 87-99.
29. TONEATTO, T., SELLERS, E. M., SOBELL, L. C. & SOBELL, M. B. (1992) Perception of whether drug or placebo had been administered as a determinant of drinking reduction, in: NARANJO, C. A. & SELLERS, E. M. (Eds) Novel Pharmacological Interventions for Alcoholism, pp. 161-183 (New York, Springer-Verlag).