PilC of pathogenic Neisseria is associated with the bacterial cell surface

Molecular Microbiology

Volumn 25, Issue 1, 1997, Pages 11-25

  Rahman, Motiur ^a   Källström, Helena ^a   Normark, Staffan ^a   Jonsson, Ann Beth ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CELL SURFACE PROTEIN;

ARTICLE; BACTERIAL MEMBRANE; BACTERIUM ADHERENCE; BACTERIUM PILUS; GENE FUNCTION; MOLECULAR CLONING; NEISSERIA MENINGITIDIS; NEISSERIACEAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); NEISSERIA; NEISSERIA MENINGITIDIS; NEISSERIACEAE;

EID: 0030875651     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1997.4601823.x     Document Type: Article

References (55)

1. Alm, R.A., Hallinan, J.P., Watson, A.A., and Mattick, J.S. (1996) Fimbrial biogenesis genes of Pseudomonas aeruginosa: pilW and pilX increase the similarity of type 4 fimbriae to the GSP protein-secretion systems and pilY1 encodes a gonococcal PilC homologue. Mol Microbiol 22: 161-173.
2. Anan, T.J., and CuNk, D.A. (1989) Neisseria gonorrhoeae dissemination and gonococcal meningitidis. J of American Board of Family Practice 2: 123-25.
3. Bradley, D.E. (1974) Basic characterization of a Pseudomonas aeruginosa pilus-dependent bacteriophage with a long non-contractile tail. J Virol 12: 1139-1148.
4. Bradley, D.E. (1980) A function of Pseudomonas aeruginosa PAO polar pili: twitching motality. Can J Microbiol 26: 146-154.
5. Brinton, C.C., Bryan, J., Dillon, J.A., Guerina, N., Jacobsen, L.J., Kraus, S., Labik, A., Lee, S., Levence, A., Lim, S., McMichael, J., Polen, S., Rogers, K., To, A.C., and To, S.C.M. (1978) Uses of pili in gonorrhoeae control: rale of bacterial pili in disease, purification and properties of gonococcal pili, and progress in the development of a gonococcal pilus vaccine for gonorrhoeae. In Immunobiology of Neisseria gonorrhoeae. Brooks, G.F., Gotschlish, E.C., Holmes, K.K., Sawyer, W.D., and Young, F. E (eds) Washington, D.C.: American Society for Microbiology, pp. 155-178.
6. Brossay, L., Paradis, G., Fox, R., Koomey, M., and Hebert, J. (1994) Identification, localization, and distribution of the PilT protein in Neisseria gonorrhoeae. Infect Immun 62: 2302-2308.
7. Danielsson, D., and Sandström, E. (1979) Serology of Neisseria gonorrhoeae. Demonstration of strain specific antigen by immunoelectrophoresis, immunofluorescence and co-agglutination techniques. Acta Path Scand 87: 55-64.
8. Drake, S.L., and Koomey, M. (1995) The product of the pilQ gene is essential for the biogenesis of type IV pili in Neisseria gonorrhoeae. Mol Microbiol 18: 975-986.
9. Drake, S., Dunham, S., and Koomey, M. (1996) Identification and characterization of PilP, a lipoprotein essential for type IV pilus biogenesis in Neisseria gonorrhoeae. In 10th International Pathogenic Neisseria Conference Meeting abstract 1996, Baltimore, Maryland, pp. 121-122.
10. Freitag, N.E., Seifert, H.S., and Koomey, M. 1995 Characterization of the pilF-pilD pilus-assembly locus of Neisseria gonorrhoeae. Mol Microbiol 16: 575-586.
11. Haas, R., and Meyer, T.F. (1986) The repertoire of silent pilus genes in Neisseria gonorrhoeae: evidence for gene conversion. Cell 44: 107-115.
12. Hagblom, P., Segal, E., Billyard, E., and So, M. (1985) Intragenic recombination leads to pilus antigenic variation in Neisseria gonorrhoeae. Nature 315: 156-158.
13. Hagman, M., Forslin, L., Moi, H., and Danielsson, D. (1991) Neisseria meningitidis in specimens from urogenital sites. Is increased awareness necessary? Sexually Transm Dis 18: 228-232.
14. Hobbs, M., and Mattick, J.S. (1993) Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes. Mol Microbiol 10: 233-243.
15. Jonsson, A-B., Nyberg, G., and Normark, S. (1991) Phase variation of gonococcal pili by frame shift mutation in pilC, a novel gene for pilus assembly. EMBO J 10: 35-43.
16. Jonsson, A-B., Pfeifer, J., and Normark, S. (1992) Neisseria gonorrhoeae PilC expression provides a selective mechanism for structural diversity of gonococcal pili. Proc Natl Acad Sci USA 89: 3204-3208.
17. Jonsson, A-B., Ilver, D., Falk, P., Pepose, J., and Normark, S. (1994) Sequence changes in the major pilus subunit of Neisseria gonorrhoeae leads to tropism variation to human tissue. Mol Microbiol 13: 403-416.
18. Jonsson, A-B., Rahman, M., and Normark, S. (1995) Pilus biogenesis gene, pilC, of Neisseria gonorrhoeae: pilC1 and pilC2 are each part of a larger duplication of the gonococcal genome and share upstream and downstream homologous sequences with opa and pil loci. Microbiology 14: 2367-2377.
19. Kellogg, D.S., Cohen, Jr., Cohen, I.R., Norins, L.C., Schroeter, A.L., and Reising, G. (1968) Neisseria gonorrhoeae. II. Clonal variation and pathogenicity during 35 months in vitro. J Bacteriol 96: 596-605.
20. Kerle, K.K., Mascola, J.R., and Miller, T.A. (1992) Disseminated gonococcal infection. Am Fam Physician 45: 209-214.
21. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
22. Meyer, T., Mlawer, N., and So, M. (1982) Pilus expression in Neisseria gonorrhoeae involves chromosomal rearrangements. Cell 30: 45-52.
23. Meyer, T.F., Billyard, E., Haas, R., Storzbach, S., and So, M. (1984) Pilus genes of Neisseria gonorrhoeae: chromosomal organization and DNA sequence. Proc Natl Acad Sci USA 81: 6110-6114.
24. Moore, T.D., and Sparling, P.F. (1995) Isolation and identification of a glutathione homologous gene, gpxA, present in Neisseria meningitidis but not absent in Neisseria gonorrhoeae. Infect Immun 63: 1603-1607.
25. Nassif, X., Lowy, J., Stenberg, P., O'Gaora, P., Ganji, A., and So, M. (1993) Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human cells. Mol Microbiol 8: 719-725.
26. Nassif, X., Beretti, J-L., Lowy, J., Stenberg, P., O'Gaora, P., Pfeifer, P., Normark, S., and So, M. (1994) Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial cells. Proc Natl Acad Sci USA 91: 3769-3773.
27. Parge, H.E., Forest, K.T., Hickey, M.J., Christensen, D.A., Getzoff, E.D., and Tainer, J.A. (1995) Structure of the fiber-forming protein pilin at 2.6 Å resolution. Nature 378: 32-38.
28. Rahman, M., and Holme, T. (1996) Antibody response in rabbits to serotype-specific determinants in lipopolysaccharides from Moraxella catarrhalis. J Med Microbiol 44: 348-354.
29. Rankin, S., Isberg, R.R., and Leong, J.M. (1992) The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells. Infect Immun 60: 3909-3912.
30. Rayner, C.F., Denwar, A., Moxon, E.R., Virji, M., and Wilson, R. (1995) The effect on the variations in the expression of pili on the interaction of Neisseria meningitidis with human nasopharyngeal epithelium. J Infect Dis 171: 113-121.
31. Rudel, T., van Putten, J.P.M., Gibbs, C.P., Haas, R., and Meyer, T.F. (1992) Interaction of two variable proteins (PilE and PilC) required for pilus-mediated adherence of Neisseria gonorrhoeae to human epithelial cells. Mol Microbiol 6: 3439-3450.
32. Rudel, T., Boxberger, H.J., and Meyer, T.F. (1995a) Pilus biogenesis and epithelial cell adherence of Neisseria gonorrhoeae pilC double knock-out mutants. Mol Microbiol 17: 1057-1071.
33. Rudel, T., Schleuerflug, I., and Meyer, T. (1995b) Neisseria PilC protein identified as type-4 pilus tip-located adhesin. Nature 373: 357-359.
34. Rudel, T., Facius, D., Barten, R., Scheuerpflug, I., nonnenmacher, E., and Meyer, T.F. (1995c) Role of pili and the phase-variable protein in natural competence for transformation of Neisseria gonorrhoeae. Proc Natl Acad Sci USA 92: 7986-7990.
35. Ryll, R.R., Rudel, T., Schleuerpflug, I., Barten, R., and Meyer, T. (1997) PilC of Neisseria meningitidis is involved in class II pilus formation and restores pilus assembly, natural transformation competence and adherence to epithelial cells in PilC-deficient gonococci. Mol Microbiol 23: 879-892.
36. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual, 2nd edn. Edited by Ford, N., Nolan, C., and Ferguson, M. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
37. Sanger, F., Nicklen, S., and Coulson, A.R. (1977) DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467.
38. Sanger, F., Coulson, A.R., Barrel, B.G., Smith, A.J.H., and Roe, B.A. (1980) Cloning in a single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol 143: 161-178.
39. Segal, E., Billyyard, E., So, M., Storzbach, S., and Meyer, T.F. (1985) Role of chromosomal rearrangement in Neisseria gonorrhoeae pilus phase variation. Cell 40: 293-300.
40. Seifert, H.S., Ajioka, R.S., Marchai, C., Sparling, P.F., and So, M. (1990) Shuttle mutagenesis of Neisseria gonorrhoeae pilin null mutations lower DNA transformation competence. J Bacteriol 172: 40-46.
41. Stimson, E., Virji, M., Makepeace, K., Dell, A., Morris, R.H., Payne, G., Saunders, J.R., Jennings, M.P., Barker, S., Panico, M., Blench, I., and Moxon, E.R. (1995) Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4-diacetamido-2,4,6-trideoxyhexose. Mol Microbiol 17: 1201-1214.
42. Stimson, E., Virji, M., Barker, S., Panico, M., Blench, I., Saunders, J., Payne, G., Moxon, E.R., Dell, A., and Morris, R.H. (1996) Discovery of a novel protein modification: α-glycerophosphate is a substituent of meningococcal pilin. Biochem J 316: 29-33.
43. Strom, M.S., Nunn, D.N., and Lory, S. (1994) Posttranslational processing of type IV prepilin and homologues by PilD of Pseudomonus aeruginosa. Methods Enzymol 235: 527-540.
44. Swanson, J. (1973) Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells. J Exp Med 137: 571-589.
45. + pilus changes in Neisseria gonorrhoeae. Cell 47: 267-276.
46. Taha, M.K., So, M., Seifert, H.S., Billyard, E., and Marchal, C. (1988) Pilin expression in Neisseria gonorrhoeae is under both positive and negative transcriptional control. EMBO J 7: 4367-4378.
47. Taha, M.K., Giorgini, D., and Nassif, X. (1996) The pilA regulatory gene modulates the pilus-mediated adhesion of Neisseria meningitidis by controlling the transcription of pilC1 Mol Microbiol 19: 1073-1084.
48. Taniguchi, T., Fujino, Y., Yamamoto, K., Miwatani, T., and Honda, T. (1995) Sequencing of the gene encoding the major pilin of pilus colonization factor antigen III (CFA/III) of human enterotoxigenic Escherichia coli and evidence that CFA/Illis related to type IV pili. Infect Immun 63: 724-728.
49. Tonjum, T., Freitag, N.E., Namork, E., and Koomey, M. (1995) Identification and characterization of pilG, a highly conserved pilus-assembly gene in pathogenic Neisseria. Mol Microbiol 16: 451-464.
50. Towbin, H., Staehelin, T., and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354.
51. Virji, M., Alexandrescu, C., Ferguson, D.J., Saunders, JR., and Moxon, ER. (1992) Variation in the expression of pili: the effect on adherence of Neisseria meningitidis to human epithelial and endothelial cells. Mol Microbiol 6: 1271-1279.
52. Virji, M., Saunders, JR., Sims, G., Makepeace, K., Maskell, D., and Ferguson, DJ. (1993) Pilus-facilitated adherence of Neisseria meningitidis to human epithelial and endothelial cells: modulation of adherence phenotype occurs concurrently with changes in primary amino acid sequence and glycosylation status of pilin. Mol Microbiol 10: 1013-1028.
53. Virji, M., Makepeace, K., Peak, I., Payne, G., Saunders, J.R., Ferguson, J.P., and Moxon, E.R. (1995) Functional implications of the expression of PilC proteins in meningococci. Mol Microbiol 16: 1087-1097.
54. Virji, M., Barker, S., and Makepeace, K. (1996) Investigations on the glycosylation status of pilins of carriage and clinical isolates of Neisseria meningitidis. In 10th International Pathogenic Neisseria Conference Meeting abstract 1996, Baltimore, Maryland, p. 324.
55. Ward, M.E., Watt, P.J., and Robertson, J.N. (1974) The human fallopian tube: a laboratory model for gonococcal infection. J Infect Dis 126: 650-659.