Mutational analysis reveals that all-trans-retinoic acid, 9-cis-retinoic acid, and antagonist interact with distinct binding determinants of RARα

Journal of Biological Chemistry

Volumn 272, Issue 29, 1997, Pages 18267-18272

  Keidel, Siegfried ^a,b   Lamour, François P Y ^a,c   Apfel, Christian M ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Quality Control and Assurance ^*  (United Kingdom)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DELETION MUTANT; LIGAND BINDING; PEPTIDE MAPPING; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING;

BENZOATES; BINDING SITES; CHROMANS; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; HUMANS; KINETICS; MUTAGENESIS, INSERTIONAL; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; RETINOIDS; SEQUENCE DELETION; TRETINOIN;

EID: 0030875552     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.29.18267     Document Type: Article

References (49)

1. Renaud, J. P., Rochel, N., Ruff, M., Vivat, V., Chambon, P., Gronemeyer, H., and Moras, D. (1995) Nature 378, 681-689
2. Tate, B. F., and Grippo, J. G. (1995) J. Biol. Chem. 270, 20258-20263
3. Lamour, F. P. Y., Lardelli, P., and Apfel, C. M. (1996) Mol. Cell. Biol. 16, 5386-5392
4. Lotan, R. (1980) Biochim. Biophys. Acta 605, 33-91
5. Roberts, A. B., and Sporn M. B. (1984) in The Retinoids (Sporn, M. B., Roberts, A. B., and Goodmann, D. S., eds) Vol. 2, pp. 210-286, Academic Press, Orlando, FL
6. Eichele, G. (1989) Trends Genet. 5, 246-251
7. Chytil, F. (1984) Pharmacol. Rev. 36, 93-100
8. Orfanos, C. E., Ehlert, R., and Gollnick, H. (1987) Drugs 34, 459-503
9. Smith, M. A., Parkinson, D. R., Cheson, B. D., and Friedman, M. (1992) J. Clin. Oncol. 10, 839-864
10. Vokes, E. E., Weichselbaum, R. R., Lipmann, S. M., and Hong, W. K. (1993) N. Engl. J. Med. 328, 184-194
11. Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R., and Thaller, C. (1992) Cell 68, 397-406
12. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberger, M., Lovey, A., and Grippo, J. F. (1992) Nature 355, 359-361
13. Mangelsdorf, D. J., Borgmeyer, U., Heymann, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A., and Evans, R. M. (1992) Genes Dev. 6, 329-344
14. Giguère, V., Ong, E. S., Segui, P., and Evans, R. M. (1987) Nature 330, 624-629
15. Petkovich, M., Brand, N. J., Krust, A., and Chambon, P. (1987) Nature 330, 444-450
16. Mangelsdorf, D. J., Ong, E. S., Dyck, J. A., and Evans, R. M. (1990) Nature 345, 224-229
17. Benbrook, D., Lernhardt, E., and Pfahl, M. (1988) Nature 333, 669-672
18. Brand, N. J., Petkowich, M., Krust, A., Chambon, P., de Thé, H., Marchio, A., Fiollais, P., and Dejean, A. (1988) Nature 332, 850-853
19. Krust, A., Kastner, P., Petkovich, M., Zelent, A., and Chambon, P. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 5310-5314
20. Zelent, A., Krust, A., Petkovich, M., Kastner, P., and Chambon, P. (1989) Nature 339, 714-717
21. Leid, M., Kastner, P., Lyons, R., Nakshrati, H., Saunders, M., Zacharewski, T., Chen, J.-Y, Staub, A., Garnier, J.-M., Mader, S., and Chambon, P. (1992-II) Cell 68, 377-395
22. Evans, R. M. (1988) Science 240, 889-895
23. Lotan, R., and Clifford, J. L. (1991) Biomed. Phamacother. 45, 145-156
24. Laudet, V., and Stehelin, D. (1992) Curr. Biol. 2, 293-295
25. Leid, M., Kastner, P., and Chambon, P. (1992-I) Trends Biochem. Sci. 17, 427-433
26. Yu, V. C., Delset, C., Andersen, B., Holloway, J. M., Devary, O. V., Näär, A. M., Kim, S. Y., Boutin, J.-M., Glass, C. K., and Rosenfeld, M. G. (1991) Cell 67, 1251-1266
27. Bugge, T. H., Pohl, J., Lonnoy, O., and Stunnenberg, H. G. (1992) EMBO J. 11, 1409-1418
28. Kliewer, S. A., Umesono, K., Mangelsdorf, D. J., and Evans, R. M. (1992) Nature 355, 446-449
29. Marks, M. S., Hallenbeck, P. L., Nagata, T., Segars, J. H., Apella, E., Nikodem, V. M., and Ozato, K. (1992) EMBO J. 11, 1419-1435
30. Zhang, X., Hoffmann, P. B.-V, Graupner, G., and Pfahl, M. (1992-I) Nature 355, 441-446
31. Apfel, C. M., Kamber, M., Klaus, M., Mohr, P., Keidel, S., and LeMotte, P. (1995) J. Biol. Chem. 270, 30765-30772
32. Schräder, M., Wyss, A., Sturzenbecker, L. J., Grippo, J. F., LeMotte, P., and Carlberg, C. (1993) Nucleic Acids Res. 21, 1231-1237
33. Mangelsdorf, D. J., Umesono K., Kliewer S. A., Borgmeyer U., Ong E. S., and Evans R. M. (1991) Cell 66, 555-561
34. Zhang, X., Lehmann, J., Hoffmann, B., Dawson, M. I., Cameron, J., Graupner, G., Hermann, G., Tran, P., and Pfahl, M. (1992) Nature 358, 587-591
35. Keller, H. J., Dreyer, C., Medin, J., Mahfoudi, A., Ozato, K., and Wahli, W. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2160-2164
36. Allenby, G., Bocquel, M. T., Sauders, M., Kazmer, M., Speck, J., Rosenberger, M., Lovey, A., Kastner, P., Grippo, J. F., Chambon, P., and Levin, A. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 30-34
37. LeMotte, P. K., Keidel, S., and Apfel, C. M. (1996) Eur. J. Biochem 236, 328-333
38. Allenby, G., Janocha, R., Kazmer, S., Speck, J., Grippo, J. F., and Levin, A. A. (1994) J. Biol. Chem. 269, 16689-16695
39. Apfel, C. M., Bauer, F., Crettaz, M., Forni, L., Kamber, M., Kaufmann, F., LeMotte, P., Pirson, W., and Klaus, M. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 7129-7133
40. Keidel, S., LeMotte, P., and Apfel, C. M. (1994) Mol. Cell. Biol. 14, 287-298
41. Lefebvre, B., Rachez, C., Formstecher, P., and Lefebvre, Ph. (1995) Biochemistry 34, 5477-5485
42. Keidel, S., Rupp, E., and Szardenings, M. (1992) Eur. J. Biochem. 204, 1141-1148
43. Green, S., Issemann, I., and Sheer, I. (1988) Nucleic Acids Res. 16, 369
44. Studier, F. W., and Moffat, B. A. (1986) J. Mol. Biol. 189, 113-130
45. Ostrowski, J., Hammer, L., Roalsvig, T., Pokornowski, K., and Reczek, P. R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1812-1816
46. Crettaz, M., Baron, A., Siegenthaler, G., and Hunziker, W. (1990) Biochem. J. 272, 391-397
47. Ekena, K., Weis, K. E., Katzenellenbogen, J. A., and Katzenellenbogen, B. S. (1997) J. Biol. Chem. 272, 5069-5075
48. Tairis, N., Gabriel, J. L., Gyda, I. I. I M., Soprano, K. J., and Soprano, D. R. (1994) J. Biol. Chem. 269, 19516-19522
49. Tairis, N., Gabriel, J. L., Soprano, K. J., and Soprano, D. R. (1995) J. Biol. Chem. 270, 18380-18387