The major histocompatability complex (mhc) contains conserved polymorphic genomic sequences that are shuffled by recombination to form ethnic-specific haplotypes

Journal of Molecular Evolution

Volumn 45, Issue 1, 1997, Pages 17-23

  Gaudieri, Silvana ^a   Leelayuwat, Chanvit ^a   Tay, Guan K ^a   Townend, David C ^a   Dawkins, Roger L ^a  

^a Ctr Molec Immunol and Instrum   (Australia)

Author keywords

Ancestral haplotypes; Homo sapiens; Major histocompatibility complex; Polymorphism; Recombination

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; BASE PAIRING; CENTROMERE; DNA POLYMORPHISM; ETHNIC GROUP; EVOLUTION; GENE DELETION; GENE DUPLICATION; GENE SEQUENCE; GENETIC RECOMBINATION; HAPLOTYPE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN;

ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; HAPLOTYPES; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID;

HOMO SAPIENS;

EID: 0030875179     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00006194     Document Type: Article

References (20)

1. Abraham LJ, Du DC, Zahedi K, Dawkins RL, Whitehead AS (1991) Haplotypic polymorphisms of the TNFB gene. Immunogenetics 33: 50-53
2. Abraham LJ, Leelayuwat C, Grimsley G, Degli-Esposti MA, Mann A, Zhang WJ, Christiansen FT, Dawkins RL (1992) Sequence differences between HLA-B and TNF distinguish different MHC ancestral haplotypes. Tissue Antigens 39:117-121
3. Abraham LJ, Marley J, Nedospasov SA, Cambon-Thomsen A, Dawkins RL, Giphart M (1993) Microsatellite, FRCP, SSO typing of the TNF region; Comparisons on the 4AOH cell panel. Hum Immunol 38:17-23
4. Cavalli-Sforza LL, Piazza A, Menozzi P, Mountain J (1988) Reconstruction of human evolution: bringing together genetic, archaeological, and linguistic data. Proc Natl Acad Sci USA 85:6002-6006
5. Dawkins RL, Degli-Esposti MA, Abraham LJ, Zhang WJ, Christiansen FT (1991) Conservation versus polymorphism of the MHC in relation to transplantation, immune responses and autoimmune disease. In: Klein J, Klein D (eds) Molecular evolution of the major histocompatibility complex. Springer-Verlag, Heidelberg, pp 391-402
6. Degli-Esposti MA, Leaver AL, Christiansen FT, Witt CS, Abraham LJ, Dawkins RL (1992) Ancestral haplotypes: conserved population MHC haplotypes. Hum Immunol 34:242-252
7. Kay PH, Dawkins RL, Williamson J, Tokunaga K, Christiansen FT (1988) Coexistence of MHC chromosal segment marked by HLA, B17, BfS, C4, A6, B1, DR7, and DQW9 in different ethnic groups. Hum Immunol 23:27-35
8. Klein J, O'Huigin C, Kasahara M, Vincek V, Klein D, Figueroa F (1991) Frozen haplotypes in Mhc evolution. In: Klein J, Klein D (eds) Molecular evolution of the major histocompatibility complex. Springer-Verlag, Berlin, pp 261-286
9. Leelayuwat C, Abraham LJ, Tabarias H, Christiansen FT, Dawkins RL (1992) Genomic organisation of a polymorphic duplicated region centromeric of HLA-B. Immunogenetics 36:208-212
10. Leelayuwat C, Zhang WJ, Townend DC, Gaudieri SG, Dawkins RL (1993) Differences in the central MHC between man and chimpanzee: implications for autoimmunity and acquired immune deficiency development. Hum Immunol 38:30-41
11. Leelayuwat C, Townend DC, Degli-Esposti MA, Abraham LJ, Dawkins RL (1994) A new polymorphic and multicopy MHC gene family related to nonmammalian class I. Immunogenetics 40:339-351
12. Leelayuwat C, Pinelli M, Dawkins RL (1995) Clustering of diverse replicated sequences in the major histocompatibility complex (MHC): evidence for en bloc duplication. J Immunol 155:692-698
13. Marshall B, Leelayuwat C, Degli-Esposti MA, Pinelli M, Abraham LJ, Dawkins RL (1993) New MHC genes. Hum Immunol 38:24-29
14. Matic I, Rayssiguier C, Radman M (1995) Interspecies gene exchange in bacteria: the role of SOS and mismatch repair systems in evolution of species. Cell 80:507-515
15. Tay GK, Witt CS, Christiansen FT, Charron D, Baker D, Hermann R, Smith LK, Diepeveen D, Mallal S, McCluskey J, Lester S, Loiseau P, Teisserence H, Chapman J, Tait B, Dawkins RL (1995) Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation. Bone Marrow Transplant 15:381-385
16. Tokunaga K, Tanaka H, Mauff G et al. (1992) Complement studies of the Eleventh International Histocompatibility Workshop. In: Tsuji K, Aizawa M, Sasazuki T (eds) HLA 1991, vol 1. Oxford University Press, New York, pp 947-954
17. Udalova IA, Nedospasov SA, Webb GC, Chaplin DD, Turetskaya RL (1993) Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics 16:180-186
18. Wu X, Zhang WJ, Witt CS, Abraham LJ, Christiansen FT, Dawkins RL (1992) Haplospecific polymorphism between HLA B and tumor necrosis factor. Hum Immunol 33:89-97
19. Zhang WJ, Degli-Esposti MA, Cobain TJ, Cameron PU, Christiansen FT, Dawkins RL (1990) Difference in gene copy number carried by different MHC ancestral haplotypes: quantitation after physical separation of haplotypes by Pulsed Field Gel Electrophoresis. J Exp Med 171:2101-2114
20. Zhang WJ, Christiansen FT, Wu X, Abraham LJ, Giphart MJ, Dawkins RL (1993) Organization and evolution of C4 and CYP21 genes in primates: importance of genomic segments. Immunogenetics 37: 170-176