Myrosinase-generated isothiocyanate from glucosinolates: Isolation, characterization and in vitro antiproliferative studies

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 9, 1997, Pages 1799-1806

  Leoni, O ^a   Iori, R ^a   Palmieri, S ^a   Esposito, E ^b   Menegatti, E ^b   Cortesi, R ^b   Nastruzzi, C ^b  

^a ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Antiproliferative activity; Glucosinolates; Isothiocyanates; Myrosinase; Phytochemicals

Indexed keywords

GLUCOCHEIROLIN; GLUCOERUCIN; GLUCONAPIN; GLUCORAPHENIN; GLUCOSINOLATE; GLUCOTROPAEOLIN; ISOTHIOCYANIC ACID DERIVATIVE; PROGOITRIN; SINALBIN; SINIGRIN; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; COLORECTAL CANCER; DRUG IDENTIFICATION; DRUG ISOLATION; ERYTHROLEUKEMIA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

CELL DIVISION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSINOLATES; GLYCOSIDE HYDROLASES; HUMANS; ISOTHIOCYANATES; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0030874661     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00112-0     Document Type: Article

References (21)

1. Graham, S.; Dayal, H.; Swanson, M.; Mittleman, A.; Wilkinson, G. J. Natl. Cancer Inst. 1978, 61, 709.
2. Manousos, O.; Day, N. E.; Trichopoulos, D.; Gerevassilis, F.; Tzonou, A.; Polychronopoulou, A. Int. J. Cancer 1983, 32, 1.
3. Lee, H. P.; Gourley, L.; Duffy, S. W.; Esteve, J.; Lee, J.; Day, N. E. Int. J. Cancer 1989, 43, 1007.
4. Fenwick, G. R.; Heaney, R. K.; Mullin, W. J. CRC Crit. Rev. Food Sci. 1983, 18, 123.
5. Pessina, A.; Thomas, R. M.; Palmieri, S.; Luisi, P. L. Arch. Biochem. Biophys. 1990, 280, 383.
6. Nastruzzi, C.; Cortesi, R.; Esposito, E.; Menegatti, E.; Leoni, O.; Iori, R.; Palmieri, S. J. Agric. Food Chem. 1996, 44, 1014.
7. Thies, W. Fat Sci. Technol. 1988, 8, 311.
8. Visentin, M.; Tava, A.; Iori, R.; Palmieri, S. J. Agric. Food Chem. 1992, 40, 1687.
9. Official Journal of European Community. Regulation (EEC) 1864/90, June Enclosure VIII, J.O. n. L170, 1990, 27-34.
10. Iori, R.; Leoni, O.; Palmieri, S. Anal. Biochem. 1983, 134, 195.
11. Leoni, O.; Marot, C.; Rollin, P.; Palmieri, S. Tetrahedron: Asymmetry 1994, 5, 1157.
12. Spencer, G. S.; Daxenbichler, M. E. J. Agric. Food Chem. 1980, 31, 359.
13. Wattemberg, L. W. Cancer Res. 1982, 2085 S.
14. Bell, J. M. J. Anim. Sci. 1984, 58, 996.
15. Zhang, G. Y.; Talalay, P.; Cho, C.; Posner, G. H. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 2399.
16. Talalay, P. In Cancer Chemoprevention. Wattenberg, L.; Lipkin, M.; Boone, C. W.; Kelloff, G. J., Eds.; CRC Press: Boca Raton, 1992; pp 469-478.
17. Tawfiq, N. Carcinogenesis 1995, 16, 1191.
18. Kawarishi, S.; Kaneko, T. J. Agric. Food Chem. 1987, 35, 85.
19. Palmieri, S.; Iori, R.; Leoni, O. J. Agric. Food Chem. 1986, 34, 138.
20. Palmieri, S.; Leoni, O.; Iori, R. Anal. Biochem. 1982, 123, 320.
21. Wheatherall, D. J.; Clegg, J. B. In The Thalassemia Syndromes. Wheatherall D. J.; Clegg J. B., Eds.; Blackwell Scientific: Oxford, 1981, pp 744-780.