An artificial metalloribonuclease based on cu(II)-terpyridine complex attached to poly(ethylenimine)

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 18, 1997, Pages 2383-2386

  Suh, Junghun ^a   Lee, Jee Yoon ^a   Hong, Sang Hyun ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER COMPLEX; POLYADENYLIC ACID; RIBONUCLEASE;

ARTICLE; CATALYSIS; DRUG SYNTHESIS; HYDROLYSIS; IN VITRO STUDY; MODEL; REACTION ANALYSIS;

EID: 0030874169     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00438-1     Document Type: Article

References (15)

1. (a) Yoshinari, K.; Yamazaki, K.; Komiyama, M. J. Am. Chem. Soc. 1991, 113, 5899.
2. (b) Shelton, V. M.; Morrow, J. R. Inorg. Chem. 1991, 30, 4295.
3. (c) Bashkin, J. K.; Frolova, E. I. J. Am. Chem. Soc. 1994, 116, 5981.
4. (d) Mesmaeker, A. D.; Häner, R.; Martin, P.; Moser, H. Acc. Chem. Res. 1995, 28, 366.
5. (e) Linkletter, B.; Chin, J. Angew. Chem. Int. Ed. Engl. 1995, 34, 472.
6. (f) Endo, M.; Hirata, K.; Ihara, T.; Sueda, S.; Takagi, M.; Komiyama, M. J. Am. Chem. Soc. 1996, 118, 5478.
7. (a) Sun, J. Acc. Chem. Res. 1992, 25, 273.
8. (b) Suh, J. In Perspectives in Bioinorganic Chemistry; Hay, R. W., Ed.; JAI Press: London, 1996; Vol. 3, pp. 115-149.
9. Stern, M. K.; Bashkin, J. K.; Sall, E. D. J. Am. Chem. Soc. 1990, 112, 5357.
10. Suh, J. In Polymeric Materials Encyclopedia; Salamone, J. C. Ed.; CRC Press: Boca Raton, 1996; 4210.
11. Suh, J.; Park, H. S. J. Polym. Sci. A: Polym. Chem. 1997, 35, 1197 and references therein.
12. Moore, C. L.; Sharp, P. A. Cell. 1985, 41, 845.
13. Molar (based on monomer concentration) extinction coefficient measured for poly(A) consisting of 300 monomers is almost identical with that (Yakovlev, G. I.; Moiseyev, G. P.; Bezborodova, S. I.; Both, V.; Sevcik, J. Eur. J. Biochem. 1992, 204, 187) of 100 monomers. Thus, initial cleavage of poly(A) is not properly reflected by Abs changes. In addition, the fragments originating from degradation of poly(A) underwent further cleavage as checked by electrophoresis even after Abs change reached a limiting value.
14. Booman, K. E.; Niemann, C. J. Am. Chem. Soc. 1956, 78, 3642.
15. Suh, J.; Paik, H.-j.; Hwang, B. K. Bioorg. Chem., 1994, 22, 318.