Detection of BCR/ABL RNA transcripts using the polymerase chain reaction is highly predictive for relapse in patients transplanted with unrelated marrow grafts for chronic myelogenous leukaemia

British Journal of Haematology

Volumn 98, Issue 2, 1997, Pages 458-466

  Drobyski, William R ^a,b   Endean, Debra J ^a   Klein, John P ^a   Hessner, Martin J ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b Bone Marrow Transplant Program   (United States)

Author keywords

BMT; CML; Minimal residual disease; PCR; Unrelated marrow transplantation

Indexed keywords

ACICLOVIR; BCR ABL PROTEIN; BUSULFAN; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; METHYLPREDNISOLONE; RNA;

ADOLESCENT; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CHILD; CHRONIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; COHORT ANALYSIS; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROGNOSIS; RELAPSE; RNA TRANSCRIPTION; TREATMENT OUTCOME;

EID: 0030873760     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.2223039.x     Document Type: Article

References (32)

1. Arcese, W., Goldman, J.M., D'Arcangelo, E., Schattenberg, A., Nardi, A., Apperley, J.F., Frassoni, F., Aversa, F., Prentice, H.G., Ljungman, P., Ferrant, A., Marosi, C., Sayer, H., Niederwieser, D., Arnold, R., Bandini, G., Carreras, E., Parker, A., Frapsaz, D., Mandelli, F. & Gratwohl, A. (1993) Outcome of patients with relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia. Blood, 82, 3211-3219.
2. Bar, B.M.A.M., Schattenberg, A., Mensink, E.J.B.M., Geurts Van Kessel, A., Smeters, T.F.C.M., Knops, G.H.J.N., Linders, E.H.P. & DeWitte, T. (1993) Donor leukocyte infusions for chronic myeloid leukaemia relapsed after allogeneic bone marrow transplantation. Journal of Clinical Oncology, 11, 513-519.
3. Baxter-Lowe, L.A., Eckels, D.D., Ash, R., Casper, J., Hunter, J.B. & Gorski, J. (1992) The predictive value of HLA-DR oligotyping for MLC responses. Transplantation, 53, 1352-1357.
4. Chomcyznski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
5. Collins, R., Shpilberg, O., Drobyski, W., Porter, D., Giralt, S., Champlin, R., Wolff, S., Hu, W., Blume, K., Verfaille, C., List, A., Ognoskie, N., Chetrit, A., Antin, J. & Nemunaitis, J. (1997) Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. Journal of Clinical Oncology, 15, 433-444.
6. Cox, D.R. (1972) Regression models and life tables (with discussion) Journal of the Royal Statistical Society B, 34, 187-220.
7. Cross, N.C., Feng, L., Chase, A., Bungey, J., Hughes, T.P. & Goldman, J.M. (1993) Competitive polymerase chain reaction to estimate the number of bcr-abl transcripts in chronic myeloid leukemia patients after bone marrow transplantation. Blood, 82, 1929-1936.
8. Delage, R., Soiffer, R.J., Dear, K. & Ritz, J. (1991) Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia. Blood, 78, 2759-2767.
9. Drobyski, W.R., Ash, R.C., Casper, J.T., McAuliffe, T., Horowitz, M.M., Lawton, C., Keever, C., Baxter-Lowe, L., Camitta, B., Garbrecht, F., Pietryga, D., Hansen, R., Chitambar, C., Anderson, T. & Flomenberg, N. (1994) Effect of T-cell depletion as graft-versus-host disease prophylaxis on engraftment, relapse, and disease-free survival in unrelated marrow transplantation for chronic myelogenous leukemia. Blood, 83, 1980-1987.
10. Drobyski, W.R., Keever, C.A., Roth, M.S., Koethe, S., Hanson, G., McFadden, P., Gottschall, J.L., Ash, R.C., van Tuinen, P., Horowitz, M.M. & Flomenberg, N. (1993) Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose. Blood, 82, 2310-2318.
11. Gratwohl, A., Hermans, J., Niederweiser, D., Frassoni, F., Arcese, W., Gahrton, G., Bandini, G., Carreras, E., Vernant, J.P., Bosi, A., de Witte, T., Fibbe, W.E., Zwaan, F., Michallet, M., Ruutu, T., Devergie, A., Iriondo, I., Apperley, J., Reiffers, J., Speck, B. & Goldman, J. (1993) Bone marrow transplantation for chronic myeloid leukemia: long term results. Bone Marrow Transplantation, 12, 509-516.
12. Hessner, M.J., Endean, D.J., Casper, J.T., Horowitz, M.M., Keever-Taylor, C.A., Roth, M., Flomenberg, N. & Drobyski, W.R. (1995) Use of unrelated marrow grafts compensates for reduced graft-versus-leukemia reactivity after T cell depleted allogeneic marrow transplantation for chronic myelogenous leukemia. Blood, 86, 3987-3996.
13. Hessner, M.J., Roth, M.S., Drobyski, W.R. & Baxter-Lowe, L.A. (1994) Development of a sensitive, highly controlled assay for molecular detection of the Philadelphia chromosome in patients with chronic myelogenous leukaemia. Genetic Analysis, Techniques and Applications, 11, 90-94.
14. Hughes, T.P., Morgan, G.J., Martiat, P. & Goldman, J.M. (1991) Detection of residual leukemia after bone marrow transplantation for chronic myeloid leukemia: role of polymerase chain in predicting relapse. Blood, 77, 874-878.
15. Kaplan, E.L. & Meier, P. (1958) Non-parametric estimation from incomplete observations. Journal of the American Statistical Association, 53, 457-481.
16. Kernan, N.A., Bartsch, G., Ash, R.C., Beatty, P.G., Champlin, R., Filipovich, A., Gajewski, J., Hansen, J.A., Henslee-Downey, J., McCullough, J., McGlave, P., Perkins, H.A., Philipps, G.L., Sanders, J., Stroncek, D., Thomas, E.D. & Blume, K.G. (1993) Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. New England Journal of Medicine, 328, 593-602.
17. Kolb, H.J., Mittermuller, J., Clemm, C.H., Holler, E., Ledderose, G., Brehm, G., Heim, M. & Wilmanns, W. (1990) Donor leukocyte infusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood, 76, 2462-2465.
18. Kolb, H.J., Schattenberg, A., Goldman, J.M., Hertenstein, B., Jacobsen, N., Arcese, W., Ljungman, P., Ferrant, A., Verdonck, L., Niederwieser, D., Van Rhee, F., Mittermuller, J., Dewitte, T., Holler, E. & Ansari, H. (1995) Graft-versus-leukemia effect of donor lymphocyte infusions in marrow grafted patients. Blood, 86, 2041-2050.
19. Lind, F., Goldman, J.M. & Cross, N.C.P. (1994) A comparison of the sensitivity of blood and bone marrow for the detection of minimal residual disease in chronic myeloid leukaemia. British Journal of Haematology, 86, 683-685.
20. Lion, T., Henn, T., Gaiger, A., Kalhs, P. & Gadner, H. (1993) Early detection of relapse after bone marrow transplantation in patients with chronic myelogenous leukaemia. Lancet, 341, 275-276.
21. MacKinnon, S., Papadopoulos, E.B., Carabasi, M.H., Reich, L., Collins, N.H., Boulad, F., Castro-Malaspina, H., Childs, B.H., Gillio, A.P., Kernan, N.A., Small, T.N., Young, J.W. & O'Reilly, R.J. (1995) Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease. Blood, 86, 1261-1268.
22. McGlave, P., Bartsch, G., Anasetti, C., Ash, R., Beatty, P., Gajewski, K. & Kernan, N.A. (1993) Unrelated donor marrow transplantation therapy for chronic myelogenous leukemia: initial experience of the National Marrow Donor Program. Blood, 81, 543-550.
23. McGlave, P.B., Beatty, P., Ash, R. & Hows, J.M. (1990) Therapy for chronic myelogenous leukemia with unrelated donor bone marrow transplantation: results in 102 cases. Blood, 75, 1728-1732.
24. McGlave, P., Kollman, C., Shu, X.O., Anasetti, C., Nademanee, A., Champlin, R., Antin, J., Kernan, N. & King, R. (1996) The first 1000 unrelated donor transplants for CML: lessons from the National Marrow Donor Program experience. Blood, 88, 483a.
25. Miyamura, K., Barrett, A.J., Kodera, Y. & Saito, H. (1994) Minimal residual disease after bone marrow transplantation for chronic myelogenous leukemia and implications for graft-versus-leukemia effect: a review of recent results. Bone Marrow Transplantation, 14, 201-209.
26. Molkentin, J., Gorski, J. & Baxter-Lowe, L.A. (1991) Detection of 14 HLA-DQB1 alleles by oligotyping. Human Immunology, 31, 114-122.
27. Radich, J.P., Gehly, G., Gooley, T., Bryant, E., Clift, R.A., Collins, S., Edmands, S., Kirk, J., Lee, A., Kessler, P., Schoch, G., Buckner, C.D., Sullivan, K.M., Appelbaum, F.R. & Thomas, E.D. (1995) Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood, 85, 2632-2638.
28. Roth, M.S., Antin, J.H., Ash, R., Terry, V.H., Gotlieb, M., Silver, S.M. & Ginsburg, D. (1992) Prognostic significant of Philadelphia chromosome-positive cells detected by the polymerase chain reaction after allogeneic bone marrow transplant for chronic myelogenous leukemia. Blood, 79, 276-282.
29. Roth, M.S., Antin, J.H., Bingham, E.L. & Ginsburg, D. (1989) Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplantation for chronic myelogenous leukemia. Blood, 74, 882-885.
30. Thomas, E.D., Clift, R.A., Fefer, A., Appelbaum, F.R., Beatty, P., Bensinger, W.I., Buckner, C.D., Cheever, M.A., Deeg, H.J., Doney, K., Flournoy, N., Greenberg, P., Hansen, J.A., Martin, P., McGuffin, R., Ramberg, R., Sanders, J.E., Singer, J., Storb, R., Sullivan, K., Weiden, P.L. & Witherspoon, R. (1986) Marrow transplantation for the treatment of chronic myelogenous leukaemia. Annals of Internal Medicine, 104, 155-163.
31. Thompson, J.D., Brodsky, I. & Yunis, J.J. (1992) Molecular quantification of residual disease in chronic myelogenous leukemia after bone marrow transplantation. Blood, 79, 1629-1635.
32. Waid, T.H., Lucas, B.A., Amlot, P., Janossy, G., Yacoub, M., Cammisuli, S., Jezek, D., Rhoades, J., Brown, S. & Thompson, J.S. (1989) T10B9.1A-31 anti-T cell monoclonal antibody: preclinical studies and clinical treatment of solid organ allograft rejection. American Journal of Kidney Diseases, 14, (Suppl. 2), 61-70.