Thrombolysis enhancing activity of a low molecular weight dermatan sulfate (Desmin 370) in experimental pulmonary embolism in rats

Thrombosis Research

Volumn 87, Issue 5, 1997, Pages 441-446

  Colucci, Mario ^a,c   Sardella, Leonardo ^a   Barbanti, Miriam ^b   Calanni, Fiorella ^b   Semeraro, Nicola ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Alfa Wassermann SpA   (Italy)

^c POLICLINICO   (Italy)

Author keywords

Anticoagulation; Dermatan sulfate; Pulmonary embolism; Rat; Thrombolysis

Indexed keywords

DERMATAN SULFATE; DESMIN; HEPARIN; HIRUDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOT LYSIS; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; FIBRINOLYSIS; LUNG EMBOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DESMIN; FIBRINOLYTIC AGENTS; HEPARIN; HIRUDIN THERAPY; MALE; PARTIAL THROMBOPLASTIN TIME; PULMONARY EMBOLISM; RATS; RATS, SPRAGUE-DAWLEY; THROMBOLYTIC THERAPY;

EID: 0030873617     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00160-6     Document Type: Article

References (8)

1. TOLLEFSEN, D.M., PESTKA, C.A. and MONAFO, W.J. Activation of heparin cofactor II by dermatan sulfate. J Biol Chem 258, 6713-6716, 1983.
2. MASCELLANI, G. and BIANCHINI, P. European patent 1990, No. 0221977; USA patent 1990, No. 4973580.
3. BARBANTI, M., CALANNI, F., MILANI, M.R., MARCHI, E., SEMERARO N. and COLUCCI, M. Therapeutic effect of a low molecular weight dermatan sulphate (Desmin 370) in rat venous thrombosis. Evidence for an anticoagulant-independent mechanism. Thromb Haemost 69, 147-151, 1993.
4. BARBANTI, M., CALANNI, F., MARCHI, E., SEMERARO, N. and COLUCCI, M. Desmin 370, a low molecular weight dermatan sulfate, reduces the weight of preformed thrombi in rats made afibrinogenemic by ancrod. Thromb Haemost 73, 287-290, 1995.
5. CLOZEL, J.P., HOLVOET, P. and TSCHOPP, T. Experimental pulmonary embolus in the rat: a new in vivo model to test thrombolytic drugs. J Cardiovasc Pharmacol 12, 520-525, 1988.
6. 125I-fibrin solid-phase fibrinolytic assay for plasmin. Blood 46, 543-553, 1975.
7. GIEZEN, J.J.J., CHUNG-A-HING, J.E., VEGTER, C.B., BOUMA, B.N., and JANSEN, J.W.C.M. Fibrinolytic activity in blood is distributed over a cellular and the plasma fraction which can be modulated separately. Thromb Haemost 72, 887-892, 1994.
8. BARBANTI, M., CALANNI, F., MARCHI, E., SEMERARO, N. and COLUCCI, M. Therapeutic efficacy of a low molecular weight dermatan sulphate (Desmin 370) in experimental venous thrombosis in rats: comparison with t-PA and u-PA. Thromb Haemost 6, 860, 1993.