Increase of bone mass and mechanical strength in rats after treatment with a novel bisphosphonate, YM175, for two years

Pharmacology and Toxicology

Volumn 81, Issue 1, 1997, Pages 42-47

  Motoie, Hiroyuki ^a   Okazaki, Atsushi ^a   Kanoh, Hiroyuki ^a   Shikama, Hisataka ^a   Fujikura, Takashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INCADRONIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BONE MASS; BONE MINERALIZATION; BONE STRENGTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMERUS; MALE; MORPHOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOLYSIS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030872899     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00029.x     Document Type: Article

References (34)

1. Adamson, B. B., S. J. Gallacher, J. Byars, S. H. Ralston, I. T. Boyle & B. F. Boyce: Mineralisation defects with pamidronate therapy for Paget's disease. Lancet 1993, II, 1459-1460.
2. Balena, R., B. C. Toolan, M. Shea, A. Markatos, E. R. Myers, S. C. Lee, E. E. Opas, J. G. Seedor, H. Klein, D. Frankenfield, H. Quartuccio, C. Fioravanti, J. Clair, E. Brown, W. C. Hayes & G. A. Rodan: The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J. Clin. Invest. 1993, 92, 2577-2586.
3. Boyce, B. F., L. Smith, I. Fogelman, E. Johnston, S. Ralston & I. T. Boyle: Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease. Lancet 1984, I, 821-824.
4. Crenshaw, T. D., E. R. Peo Jr, A. J. Lewis & B. D. Moser: Bone strength as a trait for assessing mineralization in swine: a critical review of techniques involved. J. Anim. Sci. 1981, 53, 827-835.
5. DeVries, H. R. & O. L. M. Bijvoet: Results of prolonged treatment of Paget's disease of bone with disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP). Netherl. J. Med. 1974, 17, 281-298.
6. Ferretti, J. L., G. Cointry, R. Capozza, E. Montuori, E. Roldán & A. P. Lloret: Biomechanical effects of the full range of useful doses of (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) on femur diaphyses and cortical bone tissue in rats. Bone Miner. 1990, 11, 111-122.
7. Ferretti, J. L. , N. Mondelo, R. F. Capozza, G. R. Cointry, J. R. Zanchetta & E. Montuori: Effects of large doses of olpadronate (dimethyl-pamidronate) on mineral density, cross-sectional architecture, and mechanical properties of rat femurs. Bone 1995, 16 (4, Suppl), 285S-293S.
8. Fleisch, H.: Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs 1991, 42, 919-944.
9. Flora, L., G. S. Hassing, G. G. Cloyd, J. A. Bevan, A. M. Parfitt & A. R. Villanueva: The long-term skeletal effect of EHDP in dogs. Metab. Bone Dis. Rel. Res. 1981, 4&5, 289-300.
10. Fujimoto, R., A. Nii, A. Okazaki, H. Miki & H. Kawashima: Effect of disodium dihydrogen (cyclohepthylamino) methylene bisphosphonate monohydrate (YM175) on the bone formation and resorption in rats and dogs. Histological examination. J. Bone Miner. Res. 1990, 5 (suppl 2), S157.
11. Guncaga, J., T. Lauffenburger, C. Lentner, M. A. Dambacher, H. G. Haas, H. Fleisch & A. J. Olah: Diphosphonate treatment of Paget's disease of bone. A correlated metabolic, calcium kinetic and morphometric study. Horm. Metab. Res. 1974, 6, 62-69.
12. Guy, J. A. , M. Shea, C. P. Peter, R. Morrissey & W. C. Hayes: Continuous alendronate treatment throughout growth, maturation, and aging in the rat results in increases in bone mass and mechanical properties. Calcif. Tissue Int. 1993, 53, 283-288.
13. Kawamuki, K., T. Abe, M. Kudoh, N. O'uchi, H. Motoie, T. Usui, Y. Isomura, M. Takeuchi & H. Kawashima: Effect of YM175 on bone positively correlates with its concentration in bone. J. Bone Miner. Res. 1990, 5 (suppl 2), S245.
14. Kudoh, M., T. Abe, K. Kawamuki, E. Yamaoka, Y. Isomura, M. Takeuchi & H. Kawashima: Effect of YM175 on experimental hypercalcemia and tumor-induced osteolysis in rats. J. Bone Miner. Res. 1990, 5 (suppl 2), S166.
15. Kusy, R. P. , T.-C. Peng, P. F. Hirsch & S. C. Garner: Interrelationships of bone ash and whole bone properties in the lactating and parous rat. Calcif. Tissue Int. 1987, 41, 337-341.
16. Lafage, M.-H., R. Balena, M. A. Battle, M. Shea, J. G. Seedor, H. Klein, W. C. Hayes & G. A. Rodan: Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. J. Clin. Invest. 1995, 95, 2127-2133.
17. Motoie, H., T. Nakamura, N. O'uchi, H. Nishikawa, H. Kanoh, T. Abe & H. Kawashima: Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovariectomized beagles on concomitant dietary calcium restriction. J. Bone Miner. Res. 1995, 10, 910-920.
18. Motoie, H., H. Kanoh, S. Ogata, K. Kawamuki, H. Shikama & T. Fujikura: Prevention of bone loss by bisphosphonate YM175 in ovariectomized dogs with dietary calcium restriction. Jpn. J. Pharmacol. 1996, 71, 239-246.
19. Nii, A., R. Fujimoto, A. Okazaki, K. Narita & H. Miki: Intramembranous and endochondral bone changes induced by a new bisphosphonate (YM175) in the beagle dog. Toxicol. Pathol. 1994, 22, 536-544.
20. O'Doherty, D. P. , D. R. Bickerstaff, E. V. McCloskey, N. A. T. Hamdy, M. N. C. Beneton, S. Harris, M. Mian & J. A. Kanis: Treatment of Paget's disease of bone with aminohydroxybutylidene bisphosphonate. J. Bone Miner. Res. 1990, 5, 483-491.
21. Parfitt, A. M.: The physiologic and clinical significance of bone histomorphometric data. In: Bone histomorphometry. Techniques and interpretations. Ed.: R. R. Recker, CRC Press, Inc., Boca Raton, FL, 1983, 143-223.
22. Ralston, S. H. , S. J. Gallacher, U. Patel, F. J. Dryburgh, W. D. Fraser, R. A. Cowan & I. T. Boyle: Comparison of three intravenous bisphosphonates in cancer-associated hypercalcaemia. Lancet 1989, II, 1180-1182.
23. Reginster, J. Y. , M. P. Lecart, R. Deroisy, N. Sarlet, D. Denis, D. Ethgen, J. Collette & P. Franchimont: Prevention of postmenopausal bone loss by tiludronate. Lancet 1989, II, 1469-1471.
24. Russell, R. G. G. , R. Smith, C. Preston, R. J. Walton & C. G. Woods: Diphosphonates in Paget's disease. Lancet 1974, II, 894-898.
25. Schenk, R. , P. Eggli, H. Fleisch & S. Rosini: Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat. Calcif. Tissue Int. 1986, 38, 342-349.
26. Shinoda, H., G. Adamek, R. Felix, H. Fleisch, R. Schenk & P. Hagan: Structure-activity relationships of various bisphosphonates. Calcif. Tissue Int. 1983, 35, 87-99.
27. Storm, T., G. Thamsborg, T. Steiniche, H. K. Genant & O. H. Sørensen: Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. New Engl. J. Med. 1990, 322, 1265-1271.
28. Thomas, M. L. , M. J. Ibarra, B. Solcher, S. Wetzel & D. J. Simmons: The effect of low dietary calcium and calcium supplementation on calcium metabolism and bone in immature, growing rat. Bone Miner. 1988, 4, 73-82.
29. Togari, A., M. Arai, M. Hironaka, S. Matsumoto & H. Shinoda: Effect of HEBP (1-hydroxyethylidene-1,1-bisphosphonate) on experimental osteoporosis induced by ovariectomy in rats. Jpn. J. Pharmacol. 1991, 56, 177-185.
30. Toolan, B. C., M. Shea, E. R. Myers, R. E. Borchers, J. G. Seedor, H. Quartuccio, G. Rodan & W. C. Hayes: Effects of 4-amino-1-hydroxybutylidene bisphosphonate on bone biomechanics in rats. J. Bone Miner. Res. 1992, 7, 1399-1406.
31. Turner, C.H. & D. B. Burr: Basic biomechanical measurements of bone: a tutorial. Bone 1993, 14, 595-608.
32. Usui, T. T. Watanabe & S. Higuchi: Pharmacokinetics of YM175, a new bisphosphonate, in rats and dogs. Drug Metab. Disposition 1995, 23, 1214-1219.
33. Van Beek, E. , M. Hoekstra, M. van de Ruit, C. Löwik & S. Papapoulos: Structural requirements for bisphosphonate actions in vitro. J. Bone Miner. Res. 1994, 9, 1875-1882.
34. Wronski, T. J. , C.-F. Yen & K. S. Scott: Estrogen and diphosphonate treatment provide long-term protection against osteopenia in ovariectomized rats. J. Bone Miner. Res. 1991, 6, 387-394.