Vasoactive intestinal polypeptide and pituitary adenylate cyclase- activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation

Molecular Pharmacology

Volumn 52, Issue 1, 1997, Pages 128-135

  Hashimoto, Hitoshi ^a   Ogawa, Nobuya ^a   Hagihara, Nami ^a   Yamamoto, Kyohei ^a   Imanishi, Kumiko ^a   Nogi, Hiroyuki ^a   Nishino, Akiko ^a   Fujita, Takashi ^a   Matsuda, Toshio ^a   Nagata, Shigekazu ^b   Baba, Akemichi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; IODINE 125; RADIOLIGAND; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHIMERA; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RECEPTOR BINDING;

EID: 0030872544     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.1.128     Document Type: Article

References (23)

1. Said, S. I., and V. Mutt. Polypeptide with broad biological activity: isolation from small intestine. Science (Washington D. C.) 169:1217-1218 (1970).
2. Miyata, A., A. Arimura, R. R. Dahl, N. Minamino, A. Uehara, L. Jiang, M. D. Culler, and D. H. Coy. Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Commun. 164:567-574 (1989).
3. Arimura, A. Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul. Pept. 37:287-303 (1992).
4. Gozes, I., and D. E. Brenneman. VIP: molecular biology and neurobiological function. Mol. Neurobiol. 3:201-236 (1989).
5. Kandel, E., and T. Abel. Neuropeptides, adenylyl cyclase, and memory storage. Science (Washington D. C.) 268:825-826 (1995).
6. Ishihara, T., S. Nakamura, Y. Kaziro, T. Takahashi, K. Takahashi, and S. Nagata. Molecular cloning and expression of a cDNA encoding the secretin receptor. EMBO. J. 10:1635-1641 (1991).
7. Ishihara, T., R. Shigemoto, K. Mori, K. Takahashi, and S. Nagata. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 8:811-819 (1992).
8. Hashimoto, H., T. Ishihara, R. Shigemoto, K. Mori, and S. Nagata. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron 11:333-342 (1993).
9. Harmar, T., and E. Lutz. Multiple receptors for PACAP and VIP. Trends Pharmacol. Sci. 15:97-99 (1994).
10. Xie, Y. B., H. Wang, and D. L. Segaloff. Extracellular domain of lutropin/ choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. J. Biol. Chem. 265:21411-21414 (1990).
11. Huang, R. R., D. Huang, C. D. Strader, and T. M. Fong. Conformational compatibility as a basis of differential affinities of tachykinins for the neurokinin-1 receptor. Biochemistry 34:16467-16472 (1995).
12. Holtmann, M. H., E. M. Hadac, and L. J. Miller. Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors. J. Biol. Chem. 270:14394-14398 (1995).
13. Aino, H., H. Hashimoto, N. Ogawa, A. Nishino, K. Yamamoto, H. Nogi, S. Nagata, and A. Baba. Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor. Gene (Amst.) 164:301-304 (1995).
14. Hashimoto, H., H. Aino, N. Ogawa, S. Nagata, and A. Baba. Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes. Biochem. Biophys. Res. Commun. 200:1042-1048 (1994).
15. Ishizaka-Ikeda, E., R. Fukunaga, W. I. Wood, D. V. Goeddel, and S. Nagata. Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor. Proc. Natl. Acad. Sci. USA 90:123-127 (1993).
16. Mizushima, S., and S. Nagata. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5332 (1990).
17. Baba, A., H. Saga, and H. Hashimoto. Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes. Neurosci. Lett. 149:182-184 (1993).
18. Savarese, T. M., and C. M. Fraser. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem. J. 283:1-19 (1992).
19. Sreedharan, S. P., J. X. Huang, M. C. Cheung, and E. J. Goetzl. Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene. Proc. Natl. Acad. Sci. USA 92:2939-2943 (1995).
20. Lee, C. W., M. D. Luck, H. Jüppner, Jr., J. T. Potts, Jr., H. M. Kronenberg, and T. J. Gardella. Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop. Mol. Endocrinol. 9:1269-1278 (1995).
21. Stroop, S. D., R. E. Kuestner, T. F. Serwold, L. Chen, and E. E. Moore. Chimeric human calcitonin and glucagon receptors reveal two dissociable calcitonin interaction sites. Biochemistry 34:1050-1057 (1995).
22. Siciliano, S. J., T. E. Rollins, J. DeMartino, Z. Konteatis, L. Malkowitz, G. Van Riper, S. Bondy, H. Rosen, and M. S. Springer. Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors. Proc. Natl. Acad. Sci. USA 91:1214-1218 (1994).
23. Gaudin, P., A. Couvineau, J. J. Maoret, C. Rouyer Fessard, and M. Laburthe. Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding. Biochem. Biophys. Res. Commun. 211:901-908 (1995).