Hematological responses to hydroxyurea therapy in multitransfused thalassemic children

Indian Journal of Pediatrics

Volumn 64, Issue 3, 1997, Pages 395-398

  Choudhry, Ved P ^a   Lal, Amita ^a   Pati, H P ^a   Arya, L S ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Hydroxyurea therapy; Multi transfused thalassemic

Indexed keywords

HEMOGLOBIN F; HYDROXYUREA;

ARTICLE; BLOOD TRANSFUSION; CLINICAL ARTICLE; DISEASE COURSE; FEMALE; GENE SWITCHING; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE COUNT; MALE; PRESCHOOL CHILD; RETICULOCYTE COUNT; THALASSEMIA; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 0030872518     PISSN: 00195456     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02845212     Document Type: Article

References (14)

1. Wood WG, Weatherall DJ. Developmental genetics of the human hemoglobins. Biochem J 1983; 215: 1-10.
2. Karlsson S, Nienhuis AW. Developmental regulation of human globin genes. Annu Rev Biochem 1985; 54: 1071-1108
3. LuCarelli G, Angelucci E, Giardini C, Baronciani D, Galimberts M, Palchi P and Erer B. Bone marrow transplantation in thalassemia. Ind J Pediatr 1993; 60: 517-523.
4. Gallo E, Massaro P, Miniero R, David D, Tarella C. The importance of the genetic picture and globin synthesis in determining the clinical and hematological features of thalassemia intermedia. Br J Hematol 1979; 41: 211-221.
5. Ley TJ, DeSimone J, Anagnou NP, et al. 5-Azacytidine selectively increases Y-globin synthesis in a patient with β-thalassemia. N Engl J Med 1982; 307: 1469-1475.
6. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin invest 1984; 74: 652-656.
7. Charalhe S, Dover DG, Moyer MA, Moore JW. Hydroxyurea induced augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood 1987; 69: 109-116.
8. Rodgers GP, Dover GJ, Noguchi CT, Schechter AN, Niehuis AW. Hematologic responses of patients with sickle cell disease to treatment with Hydroxyurea. N Engl J Med 1980; 322: 1037-1045.
9. Perrine SP, Cinder GD, Faller DV, et al A short term trial of butyrate to stimulate fetal globin gene expression in the beta globin disorders. N Eng J Med 1993; 328: 81-86.
10. Cleg JB, Weatherhall D, Bodmer WF: 5-Azacytidine for beta thalassemia. Lancet 1983; 1: 536-541.
11. Platt OS, Orkin SH, Dover G, Beardsley P, Murlee B and Nathan DJ. Hydroxyurea enhances Hb F production in sickle cell anemia. J Clin Invest 1984; 74: 652-656.
12. Dover GJ, Charache S Smith KD: Hydroxyurea induced augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood 1987; 69: 109-116.
13. Busslinger M, Hurst J, Fraveil RA: DNA methylation and the regulation of globin gene expression. Cell 1983; 34: 197-206.
14. Fucharoen S, Siritanaratbul N, Winichagoon P, et al. Hydroxyurea increases Hb F levels and improves the effectiveness of erythropoiesis in β thalassemia/Hb E disease. Inter Conf. thalassemia, Bombay, November 1993; 56 (Abstract).