Glycogenolysis stimulation by non-steroidal anti-inflammatories in the perfused rat liver is not accompanied by Ca2+ release

Research Communications in Molecular Pathology and Pharmacology

Volumn 96, Issue 2, 1997, Pages 193-201

  Nascimento, Écio A ^a   Tonon, F A ^a   Kelmer Bracht, Ana M ^a   Bracht, Adelar ^a   Ishii Iwamoto, E L ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; CALCIUM 45; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM CHLORIDE; CALCIUM ION; DICLOFENAC; NIFLUMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; VASOPRESSIN;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; DRUG EFFECT; GLUCOSE METABOLISM; GLYCOGENOLYSIS; LIVER METABOLISM; LIVER PERFUSION; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

2,4-DINITROPHENOL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM; DICLOFENAC; GLYCOLYSIS; LIVER; MALE; NIFLUMIC ACID; OXYGEN; RATS; RATS, WISTAR; VASOPRESSINS;

EID: 0030872473     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bergmeyer, H.U. (1970) Methoden der Enzymatischen Analyse. Verlag Chemie, Weinheim.
2. Brass, E. P. and Garrity, M. J. (1985) Effect of non-steroidal anti-inflammatory drugs on glycogenolysis in isolated hepatocytes. Br. J. Pharmacol. 86, 491-496.
3. Burch, R. M., Wise, W. C. and Halushka, P. V. (1983) Prostaglandin-independent inhibition of calcium transport by nonsteroidal anti-inflammatory drugs: differential effects of carboxylic acids and piroxicam. J. Pharmacol. Exper. Ther. 227, 84-91.
4. Ishii, E. L. and Alvarez, M. (1983) Efeito do ácido niflúmico sobre o metabolismo oxidativo de mitocôndrias de figado de rato. Arq. Biol. Tecnol. 26, 234.
5. Kelmer-Bracht, A. M., Otani, M. and Bracht, A. (1985) Ação do ácido niflúmico sobre alguns parâmetros metabólicos do figado de rato perfundido isoladamente. Rev. Unimar 7, 71-84.
6. Kelmer-Bracht, A.M. and Bracht, A. (1992) Inhibition of hepatic gluconeogenesis by niflumic acid correlates with the concentration of the free form. Res. Comm. Chem. Pathol. Pharmacol. 80, 241-248.
7. Kemmelmeier, F. S. and Bracht, A. (1989) Effects of the non-steroidal anti-inflammatory drug mefenamic acid on energy metabolism in the perfused rat liver. Biochem. Pharmacol. 38, 823-830.
8. 2+ release from the perfused liver: effects of uncoupler. Amer. J. Physiol. 258, G73-G77.
9. McDougall, P., Markham, A., Cameron, I. and Sweetman, A. J. (1983) The mechanism of inhibition of mitochondrial oxidative phosphorylation by the non-steroidal anti-inflammatory agent diflunisal. Biochem. Pharmacol. 32, 2595-2598.
10. 2+-activated ATPase of the sarcoplasmic reticulum. Biochem. J. 245, 713-722.
11. 2+. Pharmacol. Comm. 3, 129-138.
12. Nishihata, T., Ikawa, C., Saitoh, Y. and Sakai, K. (1988) Glycogenolysis in the rat isolated perfused liver as a measure of chemically induced liver toxicity. J. Pharm. Pharmacol. 40, 333-36.
13. Reinhart, P. H., Taylor, W. M. and Bygrave, F. L. (1982) Calcium ion fluxes induced by the action of α-adrenergic agonists in perfused rat liver. Biochem. J. 208, 619-630.
14. Salgueiro-Pagadigorria, C. L., Kelmer-Bracht, A. M., Bracht, A. and Ishii-Iwamoto, E. L. (1996) Effects of the nonsteroidal anti-inflammatory drug piroxicam on rat liver mitochondria. Comp. Biochem. Physiol. 113C, 85-91.
15. Scholz, R., Hansen, W. and Thurman, R. G. (1973) Interaction of mixed function oxidation with biosynthetic processes. 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver. Eur. J. Biochem. 38, 64-72.
16. Soboll, S., Scholz, R., and Heldt, H. W. (1978) Subcellular metabolite concentrations. Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver. Eur. J. Biochem. 87, 377-390.
17. Tomov, T., and Velichnikova-Markova, S. (1983) Effects of feloran on the oxidative phosphorylation of rat liver mitochondria. Acta Physiol. Pharmacol. Bulg. 9, 66-72.
18. 2+-ATPase. Biochem. 24, 7741-7745.