Variable region gene segment utilization in Rhesus monkey hybridomas producing human red blood cell-specific antibodies: Predominance of the VH4 family but not VH4-21 (V4-34)

Molecular Immunology

Volumn 34, Issue 3, 1997, Pages 237-253

  Andris, Jennifer S ^a   Miller, Amy B ^a   Abraham, Sheena R ^a   Cunningham, Susan ^a   Roubinet, Francis ^b   Blancher, Antoine ^b   Capra, J Donald ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Antibodies; B lymphocytes; Evolution; Nonhuman primate

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ARTICLE; CHROMOSOME ANALYSIS; DNA SEQUENCE; EVOLUTION; GENE STRUCTURE; GERM LINE; HYBRIDOMA; IMMUNE RESPONSE; IMMUNOGLOBULIN VARIABLE REGION; MULTIGENE FAMILY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDOGENE; RHESUS MONKEY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY DIVERSITY; BASE SEQUENCE; DNA, COMPLEMENTARY; ERYTHROCYTES; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GENES, IMMUNOGLOBULIN; HUMANS; MACACA FASCICULARIS; MACACA MULATTA; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT;

ANIMALIA; MACACA FASCICULARIS; MACACA MULATTA; PRIMATES;

EID: 0030871401     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00021-7     Document Type: Article

References (70)

1. H3b gene subfamily is highly polymorphic. J. Immun. 151, 800-809
2. Andris J. S. and Capra J. D. (1996) Variable region gene utilization in human antibodies to exogenous antigens. In The Antibodies (Edited by Zanetti M. and Capra J. D.), Harwood Academic.
3. Anstee D. J. and Mallinson G. (1994) The biochemistry of blood group antigens - some recent advances. Vox Sang. 67, 1-6.
4. Ausubel F. X., Brent R., Kingston R., Moore D., Seidman J., Smith J. and Struhl K. (1989) Current protocols in molecular biology, AnonymousGreen Publishing Associates and Wiley-Interscience, New York.
5. Becker R. S. and Knight K. L. (1990) Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits. Cell 63, 987-997.
6. Behring E. A. (1890) Uber das zustandekommen der diphtherie-immunitat und der tetanus-immunitat bei thieren. Dtsch. Med. Wochenschr. 49, 113.
7. Bhat N. M., Bieber M. M., Chapman C. J., Stevenson F. K. and Teng N. N. H. (1993) Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells. J. Immun. 151, 5011-5021.
8. Blancher A. and Socha W. W. (1991) Anti-human red cell monoclonal antibodies produced by macaque-mouse heterohybridomas. J. med. Primatol. 20, 352-356.
9. Bogard W. C. Jr, Siegel S. A., Leone A. O., Damiano E., Shealy D. J., Ely T. M., Frederick B., Mascelli M. A., Siegel R. C., Machielse B., Naveh D., Kaplan P. M. and Daddona P. E. (1993) Human monoclonal antibody HA-1A binds to endotoxin via an epitope in the lipid A domain of lipopolysaccharide. J. Immun. 150, 4438-4449.
10. Bye J. M., Carger C., Hui Y., Gorick B. D., Songsivilai S., Winter G., Hughes-Jones N. C. and Marks J. D. (1992) Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies: evidence for affinity maturation by somatic hypermutation and repertoire shift. J. Clin. Invest. 90, 2481-2490.
11. Carlson L. M., McCormack W. T., Postema C. E., Humphries E. H. and Thompson C. B. (1990) Templated insertions in the rearranged chicken IgL V gene segment arise by intrachromosomal gene conversion. Genes Dev. 4, 536-547.
12. Chen P. P., Olsen N. J., Yang P.-M., Soto-Gil R. W., Olee T., Siminovitch K. A. and Carson D. A. (1990) From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all. Int. Rev. Immun. 5, 239-251.
13. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Analyt. Biochem. 162, 156.
14. H locus completed by analysis of the telomeric region of chromosome 14q. Nature Genetics 7, 162-168.
15. H genes of human autoantibodies. Int. Rev. Immun. 5, 253-264.
16. Desiderio S. V., Yancopoulos G. D., Paskind M., Thomas E., Boss M. A., Landau N., Alt F. W. and Baltimore D. (1984) Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 311, 752-755.
17. Es J. van, Meyling F. H. J. G., van de Akker W., Aanstoot H., Derksin R. H. W. M. and Logtenberg T. (1991) Somatic mutations in the variable regions of a human IgG anti double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus. J. Exp. Med. 173, 461.
18. H locus. J. Immun. 149, 492-497.
19. Grillot-Courvalin C., Brouet J.-C., Piller F., Rassenti L. Z., Labaume S., Silverman G. J., Silberstein L. and Kipps T. J. (1992) An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells. Eur. J. Immun. 22, 1781-1788.
20. kappa recombination not encoded by germline sequences. J. Exp. Med. 166, 637-646.
21. Kasaian M. T., Ikematsu H., Balow J. E. and Casali P. (1994) Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus. J. Immun. 152, 3137-3151.
22. H gene family in hominoids and its evolutionary history. Genomics 13, 194-200.
23. Kawamura S., Omoto K. and Ueda S. (1990) Evolutionary hypervariability in the hinge region of the immunoglobulin alpha gene. J. Mol. Biol. 215, 201-206.
24. Kawamura S., Saitou N. and Ueda S. (1992) Concerted evolution of the primate immunoglobulin alpha-gene through gene conversion. J. Biol. Chem. 267, 7359-7367.
25. Kedrierski W. and Porter J. (1991) A novel nonenzymatic procedure for removing DNA template from RNA transcription mixtures. Biotechniques 10, 210.
26. Kraj P., Friedman D. F., Stevenson F. K. and Silberstein L. E. (1995) Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J. Immun. 154, 6406-6420.
27. HIII germline genes. Immun. Lett. 34, 57-62.
28. Lafaille J. J., Cloux A. de, Bonneville M., Takagaki Y. and Tonegawa S. (1989) Junctional sequences of T cell receptor gamma-delta genes: implications for gamma-delta T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59, 859.
29. Landau N. R., Schatz D. G., Rosa M. and Baltimore D. (1987) Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector. Mol. Cell. Biol. 7, 3237-3243.
30. Leoni L., Ghiso F., Goni F. and Frangione B. (1991) The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin. J. Biol. Chem. 266, 2836.
31. k segments in a murine B cell line. J. Exp. Med. 170, 1-13.
32. Matsuda F., Shin E., Nagaoka H., Matsumura R., Makoto H., Fukita Y., Taka-ishi S., Imai T., Riley J., Anand R., Soeda E. and Honjo T. (1993) Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nature Genetics 3, 88-94.
33. Meek K. D., Hasemann C. A. and Capra J. D. (1989) Novel rearrangements at the immunoglobulin D locus. J. Exp. Med. 170, 39.
34. HVl) throughout primate evolution. J. Immun. 146, 2434-2438.
35. Newman R., Alberts J., Anderson D., Carner K., Heard C., Norton F., Raab R., Reff M., Shuey S. and Hanna N. (1992) "Primatization" of recombinant antibodies for immunotherapy of human diseases: a macaque/human chimeric antibody against human CD4. Bio/Technology 10, 1455-1460.
36. Pargent W., Meindl A., Thiebe R., Mitzel S. and Zachau H. G. (1991) The human immunoglobulin kappa locus: characterization of the duplicated O regions. Eur. J. Immun. 21, 1821-1827.
37. Pascual V. and Capra J. D. (1990) Human immunoglobulin heavy chain variable region genes: organization, polymorphism and expression. Adv. Immun. 49, 1-74.
38. H gene segment overrepresented in the autoimmune repertoire. Arth. Rheum. 35, 11-18.
39. Pascual V., Randen I., Thompson K., Sioud M., Forre O., Natvig J. and Capra J. D. (1990) The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis: further evidence that some autoantibodies are unmutated copies of germline genes. J. Clin. Invest. 86, 1320-1328.
40. H4-21 gene segment is responsible for the major cross-reactive idiotype. J. Immun. 146, 4385-4391.
41. L gene segments and extensive variability in CDR-3. Scand. J. Immun. 36, 349-362.
42. H4-21 gene segment is required to encode anti-I and anti-i specificities. J. Immun. 149, 2337-2344
43. Potter K. N., Capra J. D. and Pascual V. P. (1996) Variable region genes of human antibodies to red blood cells: potential targets for superantigen interaction. In Human B Cell Superantigens (Edited by Zouali M.), pp. 225-252. R. G. Landes Company.
44. Pruzanski W. and Katz A. (1984) Cold agglutinins: antibodies with biological diversity. Clin. Immun. Rev. 3, 131-150.
45. Reynaud C.-A., Anquez V., Grimai H. and Weill J.-C. (1987) A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 48, 379-388.
46. Roelcke D. (1989) Cold agglutination. Transfus. Med. Rev. III 2, 140-166.
47. Roschenthaler F., Schable K. F., Thiebe R. and Zachau H. G. (1992) Of orphons and UHOs: delimitation of the germline repertoire of human immunoglobulin kappa genes. Biol. Chem. Hoppe-Seyler 373, 177-186.
48. Sanger F., Nicklen S. and Coulson A. R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natn. Acad. Sci. U.S.A. 74, 5463.
49. Sanz I. (1991) Multiple mechanisms participate in the generation of diversity of human H chain CDR3 V regions. J. Immun. 147, 1720.
50. H gene families display remarkably little polymorphism. EMBO J. 8, 3741-3748.
51. Scott M. G., Crimmins D. L., McCourt D. W., Chung G., Schable K. F., Thiebe R., Quenzel E.-M., Zachau H. G. and Nahm M. H. (1991) Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide IV. The less frequently expressed VL are heterogeneous. J. Immun. 147, 4007-4013.
52. Shin E. K., Matsuda F., Nagaoka H., Fukita Y., Imai T., Yokoyama K., Soeda E. and Honjo T. (1991) Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype. EMBO J. 10, 3641-3645.
53. Silberstein L. E., Jefferies L. C., Goldman J., Friedman D., Moore J. S., Nowell P. C., Roelcke D., Pruzanski W., Roudier J. and Silverman G. J. (1991) Variable region gene analysis of pathologic human autoantibodies to the related I and i red blood cell antigens. Blood 78, 2372-2386.
54. H4-21, specifically encodes autoanti-red cell antibodies against the I or i antigens. Vox Sang. 68, 231-235.
55. Songsivilai S., Bye J. M., Marks J. D. and Hughes-Jones N. C. (1990) Cloning and sequencing of human lambda immunoglobulin genes by the polymerase chain reaction. Eur. J. Immun. 20, 2661.
56. Stevenson F. K., Smith G. J., North J., Hamblin T. J. and Glennie M. J. (1989) Identification of normal B-cell counter-parts of neoplastic cells which secrete cold agglutinins of anti-I and anti-i specificity. Br. J. Haemat. 72, 9-15.
57. H4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J. Autoimmunity 6, 809-825.
58. Stevenson F. K., Spellerberg M. B., Treasure J., Chapman C. J., Silberstein L. W., Hamblin T. J. and Jones D. B. (1993) Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood 80, 224-230.
59. Stiernholm N. B. J., Kuzniar B. and Berinstein N. L. (1994) Identification of a new Vl gene family-VlX. J. Immun. 152, 4969-4975.
60. Telen M. J. (1995) Erythrocyte blood group antigens: not so simple after all. Blood 85, 299-306.
61. H4-21 variable region gene-associated epitope. Scand. J. Immun. 34, 509.
62. H segments with different hypervariable loops. J. Mol. Biol. 227, 776-798.
63. Tonegawa S. (1983) Somatic generation of antibody diversity. Nature 302, 575-581.
64. Tuaillon N., Taylor L. D., Lonberg N., Tucker P. W. and Capra J. D. (1993) Human immunoglobulin heavy-chain minilocus recombination in transgenic mice: gene-segment use in mu and gamma transcripts. Proc. Natn. Acad. Sci. U.S.A. 90, 3720.
65. Tuaillon N., Miller A. B., Tucker P. W. and Capra J. D. (1995) Analysis of direct and inverted DJH rearrangements in a human Ig heavy chain transgenic minilocus. J. Immun. 154, 6453-6465.
66. L junction. Mol. Immun. 31, 39.
67. H4 germ-line genes. Eur. J. Immun. 22, 1075-1082.
68. H4-34) gene segment. Ann. N. Y. Acad. Sci. 764, 62-71.
69. Yamada M., Wasserman R., Reichard B. A., Shane S., Caton A. J. and Rovera G. (1991) Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J. exp. Med. 173, 395.
70. H replacement by a LINE-1 sequence and directed class switching. EMBO J. 5, 3259-3266.