Macroprolactinemia: A cause of hyperprolactinemia in childhood

Journal of Pediatric Endocrinology and Metabolism

Volumn 10, Issue 4, 1997, Pages 411-417

  Fabre Brue, Catherine ^a,b   Roth, Elisabeth ^a   Simonin, Gilbert ^a   Palix, Christian ^b   Martin, Pierre Marie ^c   Brue, Thierry ^a,d  

^a TIMONE HOSPITAL   (France)

^b HÔPITAL NORD   (France)

^c Institut Jean Roche   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Chromatography; Hyperprolactinemia; Macroprolactinemia; Molecular forms; Pediatric endocrinology; Pituitary adenoma; Precocious puberty; Prolactin

Indexed keywords

PROLACTIN;

ARTICLE; CHILD; CHROMATOGRAPHY; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERPROLACTINEMIA; HYPOPHYSIS ADENOMA; IMPOTENCE; MALE; PRECOCIOUS PUBERTY; PROLACTIN BLOOD LEVEL;

EID: 0030870744     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.1997.10.4.411     Document Type: Article

References (31)

1. Andersen AN, Pedersen H, Djursing H, Andersen BN, Friesen HG. Bioactivity of prolactin in a woman with an excess of large size prolactin, persistent hyperprolactinemia and spontaneous conception. Fertil Steril 1982; 38: 625-628.
2. Andino NA, Bidot C, Valdes M, Machado AJ. Chromatographic pattern of circulating prolactin in ovulatory hyperprolactinemia. Fertil Steril 1985; 44: 600-605.
3. Jackson RD, Wortsman J, Malarkey WB. Characterization of a large molecular weight prolactin in women with idiopathic hyperprolactinemia and normal menses. J Clin Endocrinol Metab 1985; 61: 258-264.
4. Larrea F, Villanueva C, Cravioto MC, Escorza A, Del Real O. Further evidence that big big prolactin is preferentially secreted in women with hyperprolactinemia and normal ovarian function. Fertil Steril 1985; 44: 25-30.
5. Whittaker M, Wilcox T, Lind T. Maintained fertility in a patient with hyperprolactinemia due to big big prolactin. J Clin Endocrinol Metab 1981; 53: 863-866.
6. Wortsman J, Carlson HE, Malarkey WB. Macroprolactinemia as the cause of elevated serum prolactin in men. Am J Med 1989; 86: 704-706.
7. Guay AT, Sabharwal P, Varma S, Malarkey WB. Delayed diagnosis of psychological erectile dysfunction because of the presence of macroprolactinemia. J Clin Endocrinol Metab 1996; 81: 2512-2514.
8. Weill J, Petit S, Stuckens C, Descamps Y, Racadot A, Boersma A, Ponte C. Macroprolactinémie chez un enfant. Arch Fr Pediatr 1990; 47: 595-596.
9. Garner PE, Aubert ML, Kaplan SL, Grumbach MM. Heterogeneity of pituitary and plasma prolactin in man: decreased affinity of "big" prolactin in a radioreceptor assay and evidence for its secretion. J Clin Endocrinol Metab 1978; 47: 1273-1281.
10. Brue T, Caruso E, Morange I, Hoffmann T, Evrin M, Gunz G, Benkirane M, Jaquet P. Immunoradiometric analysis of circulating human glycosylated and non-glycosylated prolactin forms: spontaneous and stimulated secretion. J Clin Endocrinol Metab 1992; 75: 1338-1344.
11. Mindermann T, Wilson CB. Pediatric pituitary adenomas. Neurosurgery 1995; 36: 259-268.
12. Larrea F, Escorza A, Valero A, Hernandez L, Cravioto C, Diaz-Sanchez V. Heterogeneity of serum prolactin throughout the menstrual cycle and pregnancy in hyperprolactinemic women with normal ovarian function. J Clin Endocrinol Metab 1989; 68: 982-987.
13. Fraser IS, Lun ZG, Zhou JP, Herington AC, McCarron G, Caterson I, Tan K, Markham R. Detailed assessment of big big prolactin in women with hyperprolactinemia and normal ovarian function. J Clin Endocrinol Metab 1989; 69: 585-592.
14. Hattori N, Ishihara T, Ikekubo K, Moridera K, Hino M, Kurahachi H. Autoantibody to human prolactin in patients with idiopathic hyperprolactinemia. J Clin Endocrinol Metab 1992; 75: 1226-1229.
15. Leite V, Cosby H, Sobrinho LG, Fresnoza A, Santos MA, Friesen HG. Characterization of big big prolactin in patients with hyperprolactinemia. Clin Endocrinol 1992; 37: 365-372.
16. Brue T, Rossi E, Caruso E, Morange I, Gunz G, Priou A, Jaquet P. Hyperprolactinemia with predominant high molecular weight immuno-reactive prolactin variants: a study of 20 patients and review of literature. Exp Clin Endocrinol 1993; 12: 201-213.
17. Rogol A, Rosen SW. Prolactin of apparent large molecular size: the major immunoreactive prolactin component in plasma of a patient with a pituitary tumor. J Clin Endocrinol Metab 1974; 38: 714-717.
18. Lemaire C, Dewailly D, Racadot A, Boersma A, Lefebvre J, Fossati P. Clinical and biological features in patients with an excess of high molecular weight ("big big") prolactin in serum. Ninth International Congress of Endocrinology, Nice 1992, Abstract 07.01.036.
19. Cavaco B, Leite V, Santos MA, Arranhado E, Sobrinho LG. Some forms of big big prolactin behave as a complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactinemia or prolactinoma. J Clin Endocrinol Metab 1995; 80: 2342-2346.
20. Ohnami S, Eto S, Ohnami S, Soejima T, Nakata H. Characterization of "big big prolactin" in serum and tumor extract in patients with PRL-secreting tumor. Endocrinol Japon 1987; 34: 325-334.
21. Malarkey WB, Jackson R, Wortsman J. Long-term assessment of patients with macroprolactinemia Fertil Steril 1988; 50: 413-418.
22. Whitaker MD, Klee GG, Kao PC, Randall RV, Heser DW. Demonstration of biological activity of prolactin molecular weight variants in human sera. J Clin Endocrinol Metab 1984; 58: 826-830.
23. Carlson HE, Markoff E, Lee DW. On the nature of serum prolactin in two patients with macroprolact in emia. Fertil Steril 1992; 58: 78-87.
24. Miyai K, Ichihara K, Kondo K, Mori S. Asymptomatic hyperprolactinemia and prolactinoma in the general population - mass screening by paired assays of serum prolactin. Clin Endocrinol 1986; 25: 549-554.
25. Bjoro T, Johansen E, Frey HH, Turter A, Torjesen PA. Different responses in little and big big prolactin to metoclopramide in subjects with hyperprolactinemia due to 150-170 kD (big-big) prolactin. Acta Endocrinol 1993; 128: 308-312.
26. Hattori N, Ikekubo K, Ishihara T, Moridera K, Hino M, Kurahachi H. A normal ovulatory woman with hyperprolactinemia: presence of anti-prolactin autoantibody and the regulation of prolactin secretion. Acta Endocrinol 1992; 126: 497-500.
27. Larrea F, Escorza A, Granados J, Valencia X, Valero A, Cravioto MC, Perez-Palacios G. Familial occurrence of big-big prolactin as the predominant immunoreactive human prolactin species in blood. Fertil Steril 1987; 47: 956-963.
28. Jackson RD, Wortsman J, Malarkey WB. Persistence of large molecular weight prolactin secretion during pregnancy in women with macroprolactinemia and its presence in fetal cord blood. J Clin Endocrinol Metab 1989; 68: 1046-1050.
29. Hattori N, Ikcekubo K, Ishihara T, Mondera K, Hino M, Kurahachi H. Correlation of the antibody liters with serum prolactin levels and their clinical course in patients with antiprolactin autoantibody. Eur J Endocrinol 1994; 130: 438-445.
30. Lindstedt G. Endogenous antibodies against prolactin - a new cause of hyperprolactinemia. Eur J Endocrinol 1994; 130: 429-432.
31. Hattori N. The frequency of macroprolactinemia in pregnant women and the heterogeneity of its etiologies. J Clin Endocrinol Metab 1996; 81: 586-590.