Influence of blockade of α1-adrenoceptors, β1-adrenoceptors and vasopressin V(1A) receptors on the cardiovascular effects of γ2-melanocyte-stimulating hormone (γ2-MSH)

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 355, Issue 6, 1997, Pages 720-726

  Van Bergen, Patricia ^a   De Winter, Tessa Y C E ^a   De Wildt, Dick J ^a,b   Versteeg, Dirk H G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

2 MSH ( 2 melanocyte stimulating hormone); Blood pressure; Heart rate; Metoprolol; Prazosin; Rat; SR 49059

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; GAMMA INTERMEDIN; ISOPRENALINE; METOPROLOL; PHENYLEPHRINE; PRAZOSIN; RELCOVAPTAN; VASOPRESSIN RECEPTOR; VASOPRESSIN V1 RECEPTOR;

ADRENERGIC ACTIVITY; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOSE RESPONSE; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT;

ANIMALS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; INDOLES; MALE; MELANOCYTE-STIMULATING HORMONES; METOPROLOL; PRAZOSIN; PYRROLIDINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, VASOPRESSIN;

EID: 0030870741     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005005     Document Type: Article

References (27)

1. Brakkee JH, Wiegant VM, Gispen WH (1979) A simple technique for rapid implantation of a permanent cannula into the rat ventricular system. Lab Animal Sci 29:78-81
2. Brody MJ, Faber JE, Mangiapane ML, Porter JP (1984) The central nervous system and the prevention of hypertension. In: De Jong (ed) Handbook of hypertension. Vol. 4: Experimental and genetic models of hypertension Elsevier Science Publishers, Amsterdam, pp 474-494
3. 2-MSH. Clin Exp Hypertens A6:1727-1730
4. 2-melanocyte-stimulating hormone. Hypertension 7 [Suppl I] I-145-I-150
5. 2-MSH. J Auton Nerv Syst 24:179-182
6. 2-MSH). Brain Res 444:177-180
7. Ciriello J, Calaresu FR (1980) Role of paraventricular and supraoptic nuclei in central cardiovascular regulation in the cat Am J Physiol 239:R137-R142
8. 2-melanocyte-stimulating hormone and related melanotropins depend on the arousal potential of the rat. Eur J Pharmacol 233:157-164
9. 2-Melanocyte-Stimulating Hormone on cerebral blood flow in rats. J Cardiovasc Pharmacol 25:898-905
10. Eberle AN (1988) The melanotropins. Chemistry, physiology and mechanisms of action. S Karger Publishers. New York
11. Ferguson AV, Renaud LP (1984) Hypothalamic paraventricular lesions decrease pressor response to subfornical organ stimulation. Brain Res 305:361-364
12. Ferguson AV, Day TA, Renaud LP (1984) Subfornical organ stimulation excites paraventricular neurons projecting to the dorsal medulla. Am J Physiol 247:R1088-R1092
13. Gruber KA, Eskridge SL (1986) Central vasopressin system mediation of acute pressor effect of γ-MSH. Am J Physiol 251: E134-E137
14. Gruher KA, Callahan MF (1989) ACTH-(4-10) through γ-MSH: evidence for a new class of central autonomic nervous systemregulating peptides. Am J Physiol 257:R681-R694
15. Gruher KA, Klein MC, Hutchins PM, Buckalew VM Jr., Lymangrover JR (1984) Natriuretic and hypertensive activities reside in a fragment of ACTH. Hypertension 6:468-474
16. Jard S (1987) Vasopressin antagonists. Adv Nephrol 16:1-15
17. Klein MC, Hutehins PM, Lymangrover JR, Gruher KA (1985) Pressor and cardioaccelerator effects of gamma MSH and related peptides. Life Sci 36:769-775
18. Knupfer MM, Johnson AK, Brody MJ (1984) Identification of brainstem projections mediating hemodynamic responses to stimulation of the anteroventral third ventricle (AV3V) region. Brain Res 294:305-314
19. Manning M, Sawyer WH (1983) Design of potent in vivo antagonists of the neurohypophyseal peptides. In: Cross BA, Leng G (eds) The Neurohypophysis: Structure, Function and Control, Progr in Brain Res, vol 60 Elsevier, Amsterdam, pp 367-382
20. 2-MSH). Brain Res 480:388-392
21. 1A receptors. J Clin Invest 92:224-231
22. 2MSH in spontaneously hypertensive and normotensive rats. Am J Physiol 262:R77-R84
23. 2-MSH directly or indirectly mediated by actions on peripheral cardiovascular structures or on sympathetic neurotransmission? Can J Physiol Pharmacol 72 [Suppl 1] 412 (abstr)
24. Van Bergen P, Janssen PML, Hoogerhout P, De Wildt DJ, Versteeg DHG (1995) Cardiovascular effects of γ-MSH/ACTH-like peptides: structure-activity relationship. Eur J Pharmacol 294:795-803
25. Van Bergen P, Van der Vaart JGM, Kasbergen CM, Versteeg DHG, De Wildt DJ (1996) Structure-activity analysis for the effects of γ-MSH/ACTH-like peptides on cerebral hemodynamics in rats. Eur J Pharmacol 318:357-368
26. 2-MSH on blood pressure following intracerebrovascular and intracisternal administration. J Cardiovase Pharmacol 21:907-911
27. Weindl A (1973) Neuroendocrine aspects of circumventricular organs. In: Ganong WF, Scapagnini U, (eds) Frontiers in Neuroendocrinology Oxford University Press. Oxford, pp 3-32