Palladium(II) complexes of 2-acetylpyridine N(4)-methyl, N(4)-ethyl and N(4)-phenyl-thiosemicarbazones. Crystal structure of chloro(2-acetylpyridine N(4)-methylthiosemicarbazonato) palladium(II). Synthesis, spectral studies, in vitro and in vivo antitumour activity

Journal of Inorganic Biochemistry

Volumn 68, Issue 2, 1997, Pages 147-155

  Kovala Demertzi, Dimitra ^a   Domopoulou, Asimina ^a   Demertzis, Mavroudis A ^a   Valle, Giovanne ^b   Papageorgiou, Athanassios ^c  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY OF PADOVA   (Italy)

^c THEAGENIO CANCER HOSPITAL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETYLPYRIDINE N4 METHYL PALLADIUM(II); ANTINEOPLASTIC AGENT; CHLORO(2 ACETYLPYRIDINE N4 METHYLTHIOSEMICARBAZONATO) PALLADIUM(II); N4 METHYL PALLADIUM(II); N4 PHENYL THIOSEMICARBAZONE PALLADIUM(II); PALLADIUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG CONFORMATION; DRUG SYNTHESIS; LD 50; LEUKEMIA CELL; MURINE LEUKEMIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CRYSTALLIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; LEUKEMIA, EXPERIMENTAL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED STRAINS; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; PALLADIUM; SPECTROPHOTOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES;

EID: 0030870222     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(97)00087-1     Document Type: Article

References (25)

1. A. E. Liberta and D. X. West, Biometals 5, 121 (1992);
2. (b) W. E. Levinson, Antib. Chemother. 27, 288 (1980);
3. (c) F. A. French and E. Blanz, Jr., J. Med. Chem. 13, 1117 (1970);
4. (d) M. Karon and W. F. Benedict, Science 178, 62 (1972).
5. (a) L. A. Saryan, K. Mailer, C. Kishnamurti, W. Antholine, and D. H. Petering, Biochem. Pharmac. 30, 1595 (1981);
6. (b) A. C. Sartorelli, K. C. Agrawal, A. S. Tsiftsoglou, and A. C. Moore, Adv. Enz. Regul. 15, 117 (1977);
7. (c) J. P. Scovill, D. L. Klayman, C. Lambrose, G. E. Childs, W. Antholine, and D. H. Petering, J. Med. Chem. 27, 87 (1984).
8. (a) D. Kovala-Demertzi, A. Domopoulou, M. A. Demertzis, C. P. Raptopoulou, and A. Terzis, Polyhedron 13, 1917 (1994) and references therein;
9. (b) D. Kovala-Demertzi, A. Domopoulou, M. A. Demetrzis, J. Valdez-Martinez, J. S. Hernandez-Ortega, G. Espinosa-Perez, D. X. West, M. M. Salberg, G. A. Bain, and P. D. Bloom, Polyhedron 15, 2587 (1996) and references therein;
10. (c) D. Kovala-Demertzi, V. Varagi, M. A. Demertzis, C. P. Raptopoulou, and A. Terzis, Acta Cryst. C52, 2027 (1996);
11. (d) D. Kovala-Demertzi, A. Domopoulou, and M. A. Demetrzis, Presented in part at Nato Advanced Study Institute "Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment," Lucznik, Przesieka, Poland, June, 1996;
12. (e) A. Papageorgiou, Z. Iakovidou, D. Mourelatos, E. Mioglou, L. Boutis, A. Kotsis, D. Kovala-Demertzi, A. Domopoulou, D. X. West, and M. A. Demertzis, Anticancer Res. 17, 247 (1997).
13. D. L. Klayman, J. F. Bartosevich, T. S. Griffin, C. J. Mason, and J. P. Scovill, J. Med. Chem. 22, 855 (1979).
14. G. M. Sheldrick, SHELXT76, System of Computing Programs, University of Cambridge, 1976.
15. (a) R. G. Gugova, A. Papageorgiou, S. I. Taksirov, V. V. Topakbashian, E. Margariri, L. Boutis, D. Mouralatos, J. Dozi-Bassiliadis, E. V. Golovinsky, and G. D. Demirov, Eur. J. Med. Chem. 27, 745 (1992);
16. (b) A. Goldin, Z. Sofina, and A. Syrkin, National Cancer Inst. Monograph (USA) No. 55, 1980.
17. (a) N. K. Geary, Coord. Chem. Rev. 7, 81 (1971);
18. (b) F. Coletta, R. Ettorre, and A. Gambaro, J. Inorg. Nucl. Chem. 37, 315 (1975);
19. (c) A. R. Nicholson and G. J. Sutton, Aust. J. Chem. 22, 1543 (1969).
20. (a)L. J. Bellamy, The Infrared Spectra of Complex Molecules, Chapman and Hall, London, 1978;
21. (b) R. J. Butcher and D. X. West, Trans. Met. Chem. 18, 449 (1993);
22. (c) D. X. West, C. S. Carlson, K. J. Bouck, and A. E. Liberta, Trans. Met. Chem. 16, 271 (1991).
23. A. B. P. Lever, Inorganic Electronic Spectroscopy, Elsevier, New York, 1974.
24. (a) D. Kovala-Demertzi, A. Domopoulou, A. Michaelidis, and A. Aubry, J. Coord. Chem. (A) 30, 265 (1993);
25. (b) D. Kovala-Demertzi, A. Michaelidis, and A. Aubry, J. Inorg. Chim. Acta 194, 189 (1992).