Intracerebroventricular administration of NPY increases sympathetic tone selectively in vascular beds

Brain Research Bulletin

Volumn 44, Issue 1, 1997, Pages 97-103

  Hu, Yuange ^a   Dunbar, Joseph C ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atenolol; Iliac blood flow; MAP; NPY; Prazosin; Renal blood flow; Superior mesenteric blood flow; Sympathetic tone

Indexed keywords

ATENOLOL; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CHLORALOSE; NEUROPEPTIDE Y; PRAZOSIN; URETHAN;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR AUTOREGULATION; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DOPPLER FLOWMETRY; HEART RATE; HEMODYNAMICS; HYPOTHALAMUS; ILIAC ARTERY; KIDNEY BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY; SYMPATHETIC TONE;

ANIMALS; BLOOD PRESSURE; HEART RATE; INJECTIONS, INTRAVENTRICULAR; MALE; NEUROPEPTIDE Y; RATS; RATS, WISTAR; RENAL CIRCULATION; SYMPATHETIC NERVOUS SYSTEM;

EID: 0030869586     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00101-9     Document Type: Article

References (23)

1. Aguirre J. A., Fuxe K., Agnoti L. F. Increased vasopressure potency of centrally injected neuropeptide Y fragment 13-36 in the adult spontaneous hypertensive awake male rat of the Wistar-Kyoto strain. Acta Physiol. Scand. 139:1990;609-610.
2. Barraco R. A., Ergene E., Dunbar J. C., Ganduri Y. L., Anderson G. F. Y2 receptors for neuropeptide Y in the nucleus of the solitary tract mediate depressor responses. Peptides. 12:1991;691-698.
3. Busch-Sorensen M., Sheikh S. P., O'Hare M., Tortora O., Swartz T. W., Gammeltoft S. Regional distribution of neuropeptide Y and its receptor in the porcine central nervous system. J. Neurochem. 52:1989;1545-1552.
4. Diz D. J., Wolf C. B., Barnes K. L., Ferrario C. M. Neuropeptide Y microinjection into the ventromedial nucleus of the hypothalamus produces increases in blood pressure. Soc. Neurosci. Abstr. 12:1986;1318.
5. Dòda M. Role of different subtypes of adrenoceptors in pressor responses to catecholamines released from sympathetic nerve endings. Brain Res. Bull. 42:1997;51-57.
6. Dunbar J. C., Ergene E., Anderson G. F., Barraco R. A. Decreased cardiorespiratory effects of neuropeptide Y in the nucleus tractus solitarius in diabetes. Am. J. Physiol. 262:1992;R865-R871.
7. Ekblad E., Edvinsson L., Wohlestedt C., Uddman R., Hakanson R. Neuropeptide Y co-exist and cooperates with noradrenaline in perivascular fibers. Regul. Pept. 8:1984;225-235.
8. Evertt B. J., Hokfelt T., Terenius L., Tatemoto K., Mutt V., Goldstein M. Differential co-existence of neuropeptide-Y like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience. 11:1984;443-462.
9. Fuxe K., Agnati L. F., Harfstrand A., Zini I., Tatemoto K., Pich E. M., Hokfelt T., Mutt V., Terenius L. Central administration of neuropeptide Y induces hypotension bradypnea and EEG synchronization in the rat. Acta Physiol. Scand. 118:1983;189-192.
10. Harfstrand A. Intraventricular administration of neuropeptide Y induces hypotension, bradycardia and bradypnoea in the awake unrestrained male rat Counteraction by NPY-induced feeding behaviour. Acta Physiol. Scand. 128:1986;121-123.
11. Hokfelt T., Lundberg J. M., Lagercrantz H., Tatemoto K., Mutt V., Lindberg J., Terenius L., Everitt B. J., Fuxe K., Agniti L., Goldstein M. Occurrence of neuropeptide-Y like immunoreactivity in catecholamine neurons in the human medulla oblongata. Neurosci. Lett. 36:1983;217-222.
12. Leibowitz S. F., Alexander J. T. Analysis of neuropeptide Y-induced feeding: Dissociation of Y1 and Y2 receptor effects on natural meal patterns. Peptides. 12:1991;1251-1260.
13. Lundberg J. M., Franco-Cereceda A., Lacroix J. S., Pernow J. Neuropeptide Y and sympathetic neurotransmission. Ann. NY Acad. Sci. 611:1990;166-174.
14. Martin J. R., Beinfeld M. C., Westfall T. C. Blood pressure increases after injection of neuropeptide Y into posterior hypothalamic nucleus. Am. J. Physiol. 254:1988;H879-H888.
15. Martin J. R., Knuepfer M. M., Beinfeld M. C., Westfall T. C. Mechanism of pressor response to posterior, hypothalamic injection of neuropeptide Y. Am. J. Physiol. 257:1989;H791-H798.
16. Martin J. R., Knuepfer M. M., Westfall T. C. Hemodynamic effects of posterior hypothalamic injection of neuropeptide Y in awake rats. Am. J. Physiol. 261:1991;H814-H824.
17. Petrie J. P., Jones D. L. Lack of norepinephrine-neuropeptide Y interactions in the hypothalamic control of cardiovascular regulation in urethane-anesthetized rats. Can. J. Physiol. Pharmacol. 71:1992;326-334.
18. Petty M. A., Dietrich R., Lang R. E. The cardiovascular effects of neuropeptide Y (NPY). Clin. Exp. Hypertens. 6:1984;1889-1892.
19. Sawchenko P. E., Swanson L. W., Grzanna R., Howe P. R. C., Bload S. R., Polak J. M. Co-localization of neuropeptide Y immunoreactivity in brain stem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J. Comp. Neuro. 241:1985;138-153.
20. Scott N. A., Webb V., Boublik J. H., Rivier J., Brown M. R. The cardiovascular actions of centrally administered NPY. Regul. Pept. 25:1989;247-258.
21. Stanley B. G., Chin A. S., Leibowitz S. F. Feeding and drinking elicited by central injections of neuropeptide Y: Evidence for a hypothalamic site of action. Brain Res. Bull. 14:1985;521-524.
22. Vallejo M., Lightman S. L. Pressor effect of centrally administered neuropeptide Y in rats: Role of sympathetic nervous system and vasopressin. Life Sci. 38:1986;1859-1866.
23. Westfall T. C., Han S. P., Knuepfer M. M. J., Chen Y. L., del Valle K., Ciarleglio A., Naes L. Neuropeptides in hypertension: Role of neuropeptide Y and calcitonin gene related peptide. Br. J. Clin. Pharmacol. 30:((Suppl. 1)):1990;75s-82s.