Conformation of the C-terminal pentapeptide - The 'message sequence'- of tachykinins as determined by consensus dynamics

Journal of Biosciences

Volumn 22, Issue 3, 1997, Pages 315-324

  Kamath, Shantaram ^a   Coutinho, Evans ^a  

^a BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

Binding modes; Conformation; Consensus dynamics; Message sequence; Tachykinins

Indexed keywords

ELEDOISIN; KASSININ; NEUROKININ A; NEUROKININ B; PENTAPEPTIDE; PHYSALAEMIN; SUBSTANCE P; TACHYKININ;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 0030869255     PISSN: 02505991     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02703234     Document Type: Article

References (10)

1. Berendsen H J C, Postma J P M, van Gunsteren W F, DiNola A and Haak J R 1984 Molecular dynamics with coupling to an external bath; J. Chem. Phys. 81 3684-3690
2. Chassaing G, Convert O and Lavielle S 1986 Preferential conformation of substance P in solution; Biochemistry 154 77-85
3. Dutta A S 1990 Tachykinin receptors in Comprehensive medicinal chemistry (eds) C Hansch, P G Sammes and J B Taylor (London: Pergamon Press) Vol. 3, pp 1001-1022
4. Maple J, Dinur U and Hagler A T 1988 Derivation of force fields for molecular mechanics and dynamics from ab initio energy surfaces; Proc. Natl. Acad. Sci. U S A 85 5350-5354
5. Maple J R, Thacher T S, Dinur U and Hagler A T 1990 Biosym force field research results in new techniques for the extraction of inter-and intramolecular forces; Chem. Design Automat. News 5 5-10
6. McDowell R S, Gadek T R, Barker P L, Burdick D L, Chan K S, Quan C L, Skelton N, Struble M, Thorsett E D, Tischler M, Tom J Y K, Webb T R and Burnier J P 1994 Peptide to non-peptide: 1. The elucidation of a bioactive conformation of the arginine-glycine-aspartic acid recognition sequence; J. Am. Chem. Soc. 116 5069-5076
7. Mehlis B, Rueger M, Becker M, Bienert M, Niedrich H and Oehme P 1980 CD studies of substance P in aqueous solutions and effects of hydrogen ion concentration; Int. J. Pept. Protein Res. 15 20-28
8. Sumner S C J, Gallagher K S, Davis D G, Covell D G, Jernigan R L and Ferretti J A 1990 Conformational analysis of the tachykinins in solutions: Substance P and Physalaemin; J. Biomol. Struct. Dyn. 8 687-707
9. Verlet L 1967 Computer experiments on classical fluids I. Thermodynamical properties of Lennard-Jones molecules; Phys. Rev. 159 98-103
10. Williams R W and Weaver J L 1990 Secondary structure of substance P bound liposomes in organic solvents and in solution from Raman and CD spectroscopy; J. Biol Chem. 265 2505-2513