Sebaceous-gland deposition of isotretinoin after topical application: An in vitro study using human facial skin

Skin Pharmacology and Physiology

Volumn 10, Issue 3, 1997, Pages 126-134

  Tschan, T ^a   Steffen, H ^a   Supersaxo, A ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Acne; Drug carriers; Human facial ski; Isotretinoin; Sebaceous glands; Topical application; Transepidermal absorption; Transfollicular penetration

Indexed keywords

ALCOHOL; ISOTRETINOIN; LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ACNE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG PENETRATION; DRUG TISSUE LEVEL; FEMALE; FLUORESCENCE MICROSCOPY; GEL; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; MICELLE; PRIORITY JOURNAL; SEBACEOUS GLAND; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AUTORADIOGRAPHY; DRUG CARRIERS; FACE; FEMALE; GELS; HAIR FOLLICLE; HUMANS; ISOTRETINOIN; KERATOLYTIC AGENTS; LIPOSOMES; MICELLES; MICROSCOPY, FLUORESCENCE; SEBACEOUS GLANDS; SKIN ABSORPTION;

EID: 0030868831     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000211477     Document Type: Article

References (12)

1. Licb LM, Ramachandran C, Egba-ria K, Weiner N: Topical delivery enhancement with multilamellar liposomes into pilosebaceous units, 1. In vitro evaluation using fluorescent techniques with the hamster car model, J Invest Dermatol 1992:99: 108-113.
2. Matias JR, Malloy V, Orentreich N: A comparative study of the effects of percutaneously administered 5-a-re-ductase and androgen receptor inhibitors on hamster sebaceous glands, Ann NY Acad Sci 1984:435: 454-456.
3. Corroller M: Sebaceous accumulation of linolcic acid following topical application in the hairless rat and its mathematical treatment, Pharmacol Skin 1987;1:111-120.
4. Kellum RE: Human sebaceous gland lipids, Arch Dermatol 1967; 95:218-220.
5. Schaefer H, Stuttgcn G, Zesch A, Schalla W, Gazith J: Quantitative Determination of Percutaneous Absorption of Radiolabeled Drugs in vitro and in vivo by Human Skin, Curr Probl Dermatol, Basel, Karger, 1978. vol 7. pp 80-94.
6. Pagnoni A, Kligman AM, Gammal SEL, Stoudemayer T: Determination of density of follicles on various regions of the face by cyanoacrylate biopsy: Correlation with sebum output, Br J Dermatol 1994; 131:862-865.
7. Szabo G: The regional anatomy of the human integument with special reference to the distribution of hair follicles, sweat glands and melanocytes, Philos Trans R Soc Lond B 1967;252:447-485.
8. Lauer AC, Lieb LM, Ramachandran C, Flynn GL, Weiner ND: Transfol-licular drug delivery, Pharm Res 1995;12:179-186.
9. Jamoulle JC, Lamaud E, Grandjean L, Shroot B, Schaefer H: Follicular penetration, distribution and migration of CD271. a new naphthoic acid derivative for topical acne treatment: in Reichert U, Shroot B (eds): Pharmacology of Retinoids in the Skin, Pharmacol Skin, Basel, Karger, 1989. vol 3. p 198.
10. Hueber F, Schaefer H, Wepierre J: Effect of vehicle on transepidermal and transfoilicular absorption of four steroids of different lipophilici-ty; in Brain KR, James VJ, Walters KA (eds): Prediction of Percutaneous Penetration, Cardiff, STS Publishing, 1993. vol 3B, pp 264-271.
11. Vahlquist A, Rollman O, Holland DB, Cunliffe WJ: Isotretinoin treatment of severe acne affects the endogenous concentrations of vitamin A in sebaceous glands, J Invest Dermatol 1990;94:496-498.
12. Ryan TJ: Cutaneous circulation; in Goldsmith LA (ed): Physiology, Biochemistry, and Molecular Biology of the Skin, Oxford, Oxford University Press, 1991. PP 1019-1084.