Transient tyrosine phosphorylation of p34(cdc2) is an early event in radiation-induced apoptosis of prostate cancer cells

Prostate

Volumn 32, Issue 4, 1997, Pages 266-271

  Kyprianou, Natasha ^a   Bains, Arvinder ^a   Rhee, Juong G ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Prostate cancer; Radiation induced apoptosis; Suramin; Tyrosine phosphorylation

Indexed keywords

DNA FRAGMENT; FLUORESCEIN; PROTEIN SERINE THREONINE KINASE; SURAMIN; TYROSINE;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS INHIBITION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

APOPTOSIS; CDC2 PROTEIN KINASE; CELL SURVIVAL; DNA FRAGMENTATION; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; KINETICS; MALE; PHOSPHOPROTEINS; PHOSPHOTYROSINE; PROSTATIC NEOPLASMS; RADIATION, IONIZING; SURAMIN; TUMOR CELLS, CULTURED;

EID: 0030868688     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19970901)32:4<266::AID-PROS6>3.0.CO;2-H     Document Type: Article

References (21)

1. Ward JF: DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation and repairability. Prog Nucleic Acid Res Mol Biol 1988;35:95-125.
2. Painter RB: The role of DNA damage and repair in cell killing induced by ionizing radiation. In Meyn RE, Withers HR (eds): "Radiation Biology in Cancer Research," New York: Raven Press, 1980:59-68.
3. Weinert TA, Hartwell LH: The RAD 9 gene controls the cell cycle response to DNA damage in Sacharomyces cerevisniae. Science 1988;241:317-322.
4. Nurse P: Universal control mechanism regulating onset of M-phase. Nature 1990;344:503-508.
5. Draetta G, Beach D: Activation of cdc2 protein kinase during mitosis in human cells: Cell dependent phosphorylation and subunit rearrangement. Cell 1988;54:17-26.
6. Morla AO, Draetta G, Beach D, Wang J: Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis. Cell 1989;58:193-203.
7. Schieven G, Kirihara L, Uckum F, Ledbetter J: Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes. Mol Biol Cell 1993;4:523-530.
8. cdc2 kinase. Cancer Res 1994;54:1412-1414.
9. cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Res 1990;50:3761-3766.
10. Raff M: Social control on cell survival and cell death. Nature 1992;356:397-399.
11. Wyllie AH, Kerr JFR, Currie AR: Cell death: The significance of apoptosis. Int Rev Cytol 1980;68:251-306.
12. Kyprianou N, Martikainen P, Davis L, English HF, Isaacs JT: Programmed cell death as a new target for prostatic cancer therapy. Cancer Surv 1991;11:265-277.
13. Sklar JN, Eddy HA, Jacobs SC, Kyprianou N: Combined antitumor effect of suramin plus irradiation in human prostate cancer cells: The role of apoptosis. J Urol 1993;150:1526-1532.
14. Uckun FM, Tuel-Ahlgren L, Song SW, Waddick K, Myers DE, Kiriahara J, Ledbetter JA, Schieven GL: Ionizing irradiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors triggering apoptosis and clonogenic cell death. Proc Natl Acad Sci USA 1992;89:9005-9009.
15. Fuks Z, Perand RS, Alfieri A, McLoughlin M, Ehleiter D, Schwartz JL, Seddon AP, Cordon-Carlo C, Haimovitz-Freindman A: Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res 1994;54:2582-2590.
16. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
17. Kim JH, Sherwood ER, Sutkoski DM, Lee C, Kozlowski JM: Inhibition of prostatic tumor cell proliferation by suramin: Alterations in TGF alpha mediated autocrine growth regulation and cell cycle distribution. J Urol 1991;146:171-176.
18. O'Connor PM, Kohn KW: A fundamental role for cell cycle regulation in the chemosensitivity of cancer cells. Semin Cancer Biol 1992;3:409-416.
19. cdc2 tyrosine phosphorylation and mitotic progression in Chinese hamster ovary cells exposed to etoposide. Cancer Res 1992;52:1817-1822.
20. cdc2 activation required for apoptosis. Science 1994;263:1143-1145.
21. Chae H, Jarvis L, Uckum F: Role of tyrosine phosphorylation in radiation-induced activation of c-jun proto-oncogene in human lymphohematopoietic precursor cells. Cancer Res 1993;53:447-4561.