Dopamine and intestinal mucosal tissue oxygenation in a porcine model of haemorrhage

British Journal of Anaesthesia

Volumn 79, Issue 3, 1997, Pages 357-362

  Germann, R ^a   Haisjackl, M ^a   Schwarz, B ^a   Salak, N ^a   Deusch, E ^a   Pajk, W ^a   Wolf, H J ^a   Riedmann, B ^a   Hasibeder, W ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Complications, haemorrhage; Gastrointestinal tract, mucosal oxygenation; Pig; Sympathetic nervous system, dopamine

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; DOPAMINE; HEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD VOLUME; CONTINUOUS INFUSION; CONTROLLED STUDY; HYPOXIA; INTESTINE MUCOSA; INTRAVENOUS DRUG ADMINISTRATION; JEJUNUM; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN SATURATION; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RESUSCITATION; SWINE; TISSUE OXYGENATION;

EID: 0030868455     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/79.3.357     Document Type: Article

References (29)

1. Redfors S, Hallbäck DA, Sjövall H, Jodal M, Lundgren O. Effects of haemorrhage on intramural blood flow distribution, villous tissue osmolaliry and fluid and electrolyte transport in the small intestine. Acta Physiologica Scandinavica 1984; 121: 211-222.
2. Zabel DD, Hopf HW, Hunt TK. Transmural gut oxygen gradients in shocked rats resuscitated with heparan. Archives of Surgery 1995; 130: 59-63.
3. Deitch EA, Morrison J, Berg R, Specian RD. Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. Critical Care Medicine 1990; 18: 529-536.
4. Haglund U. Gut ischaemia. Gut 1994; (Suppl. 1): S73-76.
5. Robie NW, Goldberg LI. Comparative systemic and regional hemodynamic effects of dopamine and dobutamine. American Heart Journal 1975; 90: 340-345.
6. Kullmann R, Breull WR, Wassermann K, Konopatzki A. Blood flow redistribution by dopamine in the feline gastrointestinal tract. Naunyn-Schmiedebergs Archives of Pharmacology 1983; 323: 145-148.
7. Germann R, Haisjackl M, Hasibeder W, Sparr H, Luz G, Plattner R, Pernthaler H, Friesenecker B, Falk M. Dopamine and mucosal oxygenation in the porcine jejunum. Journal of Applied Physiology 1994; 77: 2845-2852.
8. Schmidt H, Secchi A, Wellmann R, Bohrer H, Bach A, Martin E. Effect of low-dose dopamine on intestinal villus microcirculation during normotensive endotoxaemia in rats. British Journal of Anaesthesia 1996; 76: 707-712.
9. Hasibeder W, Germann R, Wolf HJ, Haisjackl M, Hausdorfer H, Riedmann B, Bonatti J, Pfaller K, Gruber E, Schwarz B, Waldenberger P, Furtner B. The effects of shortterm endotoxemia and dopamine on mucosal oxygenation in the porcine jejunum. American Journal of Physiology 1996; 270: G667-675.
10. Dodds WJ. The pig model for biomedical research. Federation Proceedings 1982; 41: 247-256.
11. Hasibeder W, Germann R, Sparr H, Haisjackl M, Friesenecker B, Luz G, Pernthaler H, Pfaller K, Maurer H, Ennemoser O. Vasomotion induces regular major oscillations in jejunal mucosal tissue oxygenation. American Journal of Physiology 1994; 266: G978-986.
12. Sato N, Kamada T, Shichiri M, Kawano S, Abe H, Hagihara B. Measurements of hemoperfusion and oxygen sufficiency in gastric mucosa in vivo. Gastroenterology 1979; 76: 814-819.
13. Leung FW, Morishita T, Livingston EH, Reedy T, Guth PH. Reflectance spectrophotometry for the assessment of gastroduodenal mucosal perfusion. American Journal of Physiology 1987; 252: G797-804.
14. Yasue N, Chan ETY, Kaplowitz N, Guth PH. Effect of phorone and allopurinol on ischaemia-reperfusion injury in gastrointestinal mucosa of the rat. Pharmacology 1992; 44: 334-343.
15. Bond JH, Levitt MD. Distribution of blood flow to the small intestinal mucosa. Gastroenterology 1976; 70: A866.
16. Kessler M, Harrison DK, Höper J. Tissue oxygen measurement techniques. In: Baker CH, Nastuk WL, eds. Microcirculatory Technology. Orlando: Academic Press, 1986; 391-425.
17. 2 and microvascular responses during glucose exposure. American Journal of Physiology 1980; 238: H164-171.
18. Shepherd AP, Kiel JW. A model of countercurrent shunting of oxygen in the intestinal villus. American Journal of Physiology 1992; 262: H1136-1142.
19. Giraud GD, MacCannell KL. Decreased nutrient blood flow during dopamine-and epinephrine-induced intestinal vasodilation. Journal of Pharmacology and Experimental Therapeutics 1984; 230: 214-220.
20. Kullmann R, Breull WR, Reinsberg J, Wassermann K, Konopatzki A. Dopamine produces vasodilation in specific regions and layers of the rabbit gastrointestinal tract. Life Sciences 1983; 32: 2115-2122.
21. Germann R, Hasibeder W, Haisjackl M, Sparr H, Luz G, Pernthaler H, Friesenecker B, Bonatti J, Gruber E, Schwarz B. Dopamine-1-receptor stimulation and mucosal tissue oxygenation in the porcine jejunum. Critical Care Medicine 1995; 23: 1560-1566.
22. Hall RC, Hodge RL. Changes in catecholamine and angiotensin levels in the cat and dog during hemorrhage. American Journal of Physiology 1971; 221: 1305-1309.
23. Rush BF, Sori AJ, Murphy TF, Smith S, Flanagan JJ, Machiedo GW. Endotoxemia and bacteremia during hemorrhagic shock. The link between trauma and sepsis? Annuals of Surgery 1988; 207: 549-554.
24. Kullmann R, Wassermann K, Rissing R, Huss R. Species differences of dopaminergic vasodilation in the intestine. In: Imbs Jl, Schwarz J, eds. Peripheral Dopaminergic Receptors. Oxford, UK: Pergamon, 1979; 199-210.
25. Shepperson NB, Duval N, Langer SZ. Dopamine decreases mesenteric blood flow in the anaesthetised dog through the stimulation of postsynaptic 2-adrenoceptors. European Journal of Pharmacology 1982; 81: 627-635.
26. Van Woerkens LJ, Duncker DJ, Den Boer MO, McFalls EO, Sassen LMA, Saxena PR, Verdouw PD. Evidence against a role for dopamine D1 receptors in the myocardium of the pig. British Journal of Pharmacology 1991; 104: 246-250.
27. Fiddian-Green RG. Gastric intramucosal pH, tissue oxygenation and acid-base balance. British Journal of Anaesthesia 1995; 74: 591-606.
28. Marik PE, Mohedin M. The contrasting effects of dopamine and norephinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. Journal of the American Medical Association 1994; 272: 1354-1357.
29. Toda N, Okunishi H, Okamura T. Responses to dopamine of isolated human gastroepiploic arteries. Archives Internationales de Pharmacodynamie et de Therapie 1989; 297: 86-97.