Hypoxemia and hypoxic pulmonary vasoconstriction: Autonomic nervous system versus mixed venous P(O2)

Respiration Physiology

Volumn 109, Issue 3, 1997, Pages 249-260

  Pellett, Andrew A ^a   Cairo, Jimmy M ^a   Levitzky, Michael G ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

Autonomic nervous system; Hypoxia; Hypoxic pulmonary vasoconstriction; Mammals dog; Oxygen mixed venous; Pulmonary circulation; Pulmonary vasoconstriction

Indexed keywords

ATROPINE; PROPRANOLOL;

ARTICLE; AUTONOMIC NERVOUS SYSTEM; CHEMORECEPTOR; CONTROLLED STUDY; DOG; HYPOXEMIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG BLOOD FLOW; LUNG VENTILATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANOXEMIA; ANOXIA; ATROPINE; AUTONOMIC NERVOUS SYSTEM; DOGS; FEMALE; LUNG; MALE; MUSCARINIC ANTAGONISTS; NITROGEN; OXYGEN; PROPRANOLOL; PULMONARY CIRCULATION; RESPIRATION, ARTIFICIAL; VASOCONSTRICTION;

EID: 0030868059     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(97)00055-8     Document Type: Article

References (25)

1. O2 on hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 51, 871-874.
2. Chapleau, M.W., Wilson, L.B., Gregory, T.J., Levitzky, M.G., 1988. Chemoreceptor stimulation interferes with regional hypoxic pulmonary vasoconstriction. Respir. Physiol. 71, 185-200.
3. Eyzaguirre, C., Fitzgerald, R.S., Lahiri, S., Zapata, S., 1983. Arterial chemoreceptors. In: Shepherd, J.T., Abboud, F.M. (Eds.), Handbook of Physiology, sect. 2: The Cardiovascular System, vol. III: Peripheral Circulation and Organ Blood Flow, part 2, Williams and Wilkins, Bethesda, MD, pp. 557-621.
4. Fishman, A.P., 1985. Pulmonary circulation. In: Fishman, A.P., Fisher, A.B. (Eds.), Handbook of Physiology, sect. 3: The Respiratory System, vol. I: Circulation and Nonrespiratory Functions, Williams and Wilkins, Bethesda, MD, pp. 93-166.
5. Fitzgerald, R.S., Shirahata, M., 1994. Acetylcholine and carotid body excitation during hypoxia in the cat. J. Appl. Physiol. 76, 1566-1574.
6. Fitzgerald, R.S., Dehghani, G.A., Sham, J.S.K., Shirahata, M., Mitzner, W.A., 1992. Peripheral chemoreceptor modulation of the pulmonary vasculature in the cat. J. App. Physiol. 73, 20-29.
7. O2. Am. J. Physiol. 250, H434-H442.
8. Hughes, J.D., Rubin, L.J., 1984. Relation between mixed venous oxygen tension and pulmonary vascular tone during normoxic, hyperoxic and hypoxic ventilation in dogs. Am. J. Cardiol. 54, 1118-1123.
9. Lejeune, P., Vachiery, J.-L., Leeman, M., Brimioulle, S., Hallemans, R., Melot, C., Naeije, R., 1989. Absence of parasympathetic control of pulmonary vascular pressure-flow plots in hyperoxic and hypoxic dogs. Respir. Physiol. 78, 123-134.
10. Levitzky, M.G., 1979. Chemoreceptor stimulation and hypoxic pulmonary vasoconstriction in conscious dogs. Respir. Physiol. 37, 151-160.
11. Levitzky, M.G., Newell, J.C., Krasney, J.A., Dutton, R.E., 1977. Chemoreceptor influence on pulmonary blood flow during unilateral hypoxia in dogs. Respir. Physiol. 31, 345-356.
12. Lodato, R.F., Michael, J.R., Murray, P.A., 1988. Absence of neural modulation of hypoxic pulmonary vasoconstriction in conscious dogs. J. Appl. Physiol. 65, 1481-1487.
13. 2 concentrations on hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 34, 318-323.
14. Marshall, B.E., Marshall, C., Benumof, J., Saidman, L.J., 1981. Hypoxic pulmonary vasoconstriction in dogs: effects of lung segment size and oxygen tension. J. Appl. Physiol. 51, 1543-1551.
15. O2 on pulmonary vascular resistance. J. Appl. Physiol. 70, 405-415.
16. Marshall, B.E., Clarke, W.R., Costarino, A.T., Chen, L., Miller, F., Marshall, C., 1994. The dose-response relationship for hypoxic pulmonary vasoconstriction. Respir. Physiol. 96, 231-247.
17. Nadel, J.A., Widdicombe, J.G., 1962. Effect of changes in blood gas tensions and carotid sinus pressure on tracheal volume and total lung resistance to airflow. J. Physiol. (Lond.) 163, 13-33.
18. Naeije, R., Lejeune, P., Leeman, M., Melot, C., Closset, J., 1989. Pulmonary vascular responses to surgical chemodenervation and chemical sympathectomy in dogs. J. Appl. Physiol. 66, 42-50.
19. O2. J. Appl. Physiol. 40, 883-888.
20. O2 interaction on hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 53, 134-139.
21. Schumacker, P.T., Newell, J.C., Saba, T.M., Powers, S.R., 1981. Ventilation-perfusion relationships with high cardiac output in lobar atelectasis. J. Appl. Physiol. 50, 341-347.
22. Shirai, M., Shindo, T., Ninomiya, I., 1994. β-Adrenergic mechanisms attenuate hypoxic pulmonary vasoconstriction during systemic hypoxia in cats. Am. J. Physiol. 266, H1777-H1785.
23. Sylvester, J.T., Harabin, A.L., Peake, M.D., Frank, R.S., 1980. Vasodilator and constrictor responses to hypoxia in isolated pig lungs. J. Appl. Physiol. 49, 820-825.
24. Weiner, N., 1980. Atropine, scopolamine, and related antimuscarinic drugs. In: Gilman, A.G., Goodman, L.S., Gilman, A. (Eds.) Goodman and Oilman's The Pharmacological Basis of Therapeutics, MacMillan, New York, pp. 120-137.
25. Wilson, L.B., Levitzky, M.G., 1989. Chemoreflex blunting of hypoxic pulmonary vasoconstriction is vagally mediated. J. Appl. Physiol. 66, 782-791.