Novel cost-effective methanephosphonoanilidothioate approach to the stereoselective synthesis of dinucleoside (3',5')-methanephosphonates

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 4, 1997, Pages 381-395

  Steg, Wojciech J ^a   Woźniak, Lucyna A ^a   Pyzowski, Jarostaw ^a   Niewiarowski, Wojciech ^a  

^a CENTRE OF MOLECULAR AND MACROMOLECULAR STUDIES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYRIBOSE; BISPHOSPHONIC ACID DERIVATIVE; DINUCLEOSIDE PHOSPHATE; NUCLEOTIDE DERIVATIVE; RIBONUCLEOSIDE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; PRIORITY JOURNAL; STEREOSPECIFICITY; SYNTHESIS;

EID: 0030867552     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.381     Document Type: Article

References (6)

1. AGARWAL, K.L., and RIFTINA, F. (1979). Synthesis and enzymatic properties of deoxyribonucleotides containing methyl and phenylphosphonate linkages. Nucleic Acids Res. 6, 3009-3024.
2. AGRAWAL, S., TEMSAMANI, J., GALBRAITH, W., and TANG, J. (1995). Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28, 7-16.
3. AMATO, I. (1992). Looking glass chemistry. Science 256,964.
4. 18O]-phosphates. J. Chem. Soc., Perkin Trans. I, 1645-1656.
5. BEARY, J.F., and EATON, C.R. (1992). Chirality and drug development. Science 257, 145.
6. WOZNIAK, L.A., WIECZOREK, M, PYZOWSKI, J., MAJZNER, W., and STEC, W.J. (1997). Stereochemistry of the DBU/LiCl assisted nucleophilic substitution at phosphorus in nucleoside-3′-O-(Semethyl methanephosphonoselenolate)s-submitted for publication.