Information processing and intracellular 'neural' (protein) networks: Considerations regarding the diffusion-based hypothesis of Bray

Biology of the Cell

Volumn 89, Issue 1, 1997, Pages 13-18

  Agutter, Paul S ^a   Wheatley, Denys N ^b  

^a EDINBURGH NAPIER UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Circuits; Information; Memory; Network; Proteins; Signalling

Indexed keywords

CELL PROTEIN;

COGNITION; DIFFUSION; HYPOTHESIS; INFORMATION; INFORMATION PROCESSING; MEMORY; MODEL; NERVE CELL NETWORK; NERVOUS SYSTEM FUNCTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030867471     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0248-4900(99)80077-X     Document Type: Article

References (24)

1. Agutter PS, Malone PC and Wheatley DN (1995) Intracellular transport mechanisms: a critique of diffusion theory. J Theor Biol 176, 261-272
2. Aitken A (1996) 14-3-3 and its possible role in co-ordinating multiple signalling pathways. Trends Cell Biol 6, 341-347
3. Amit D (1989) Modelling Brain Function. Cambridge University Press, Cambridge
4. Amit D, Gutfreund H and Sompolinsky H (1985) Storing infinite numbers of patterns in a spin-glass model of neural networks. Phys Rev Lett 55, 1530-1533
5. Amit D, Gutfreund H and Sompolinsky H (1987) Information storage in neural networks with low levels of activity. Phys Rev A 35, 2293-2303
6. Arkin A and Ross J (1994) Computational functions in biochemical reaction networks. Biophys J 67, 560-578
7. Bray D (1990) Intracellular signalling as a parallel distributed process. J Theor Biol 143, 215-231
8. Bray D (1995) Protein molecules as computational elements in living cells. Nature 376, 307-312
9. Darnell JE (1982) Variety in the level of gene control in eukaryotic cells. Nature 297, 365-371
10. Grisolia S and Wheatley DN (1984) Intracellular degradation of endogenous proteins and its regulation. Life Chem 2, 257-297
11. Grisolia S, O'Connor E, Burgal M and Wheatley DN (1983) Molecular aspects of neuronal plasticity. In: Ramón y Cajal's Contribution to Neurosciences (Grisolía S, Samson F, Norton S, Reinoso-Suárez F, eds) Elsevier Biomedical Press, Amsterdam 35-47
12. Hailing PJ (1989) Do the laws of chemistry apply to living cells? Trends Biochem Sci 14, 317-318
13. Hellingwerf KJ, Postma PW, Tommassen J and Westerhoff HV (1995) Signal transduction in bacteria; phospho-neural network(s) in Escherichia coli. FEMS Microbiol Rev 16, 309-321
14. Hepler JR and Gilman AG (1992) G proteins. Trends Biochem Sci 17, 383-387
15. Luby-Phelps K (1994). Physical properties of cytoplasm. Curr Opin Cell Biol 6, 3-9
16. Kandel ER (1981). Calcium and the control of synaptic strength by learning. Nature 293, 697-700
17. Neer EJ (1995) Heteromeric G proteins: organizers if transmembrane signals. Cell 80, 249-257
18. Paine PL (1984). Diffusive and non-diffusive proteins in vivo. J Cell Biol 99, 188S-194S
19. Penrose R (1994). Shadows of the Mind. Oxford University Press, Oxford
20. Shacter E, Chock PB and Stadtman ER (1984) Regulation through phosphorylation/dephosphorylation. J Biol Chem 259, 12252-12259
21. Simon MI, Strathmann MP and Gautam N (1991) Diversity of G proteins in transmembrane signalling. Science 252, 802-808
22. Wheatley DN (1987). Predictability of the 'selection' of proteins for degradation. Microbios Lett 36, 77-84
23. Wheatley DN and Malone PC (1993) Heat conductance, diffusion theory and intracellular metabolic regulation. Biol Cell 79, 1-5
24. Wojcieszyn JW, Schlegel RA, Wu E-S and Jacobson KA (1981) Diffusion of injected macromolecules within the cytoplasm of living cells. Proc Natl Acad Sci USA 78, 4407-4410