메뉴 건너뛰기




Volumn 11, Issue 5, 1997, Pages 416-426

In vitro calcium antagonistic and antioxidant effects of Org 13061 and its enantiomers, new potential antiatherosclerotic compounds

Author keywords

Antioxidants; Calcium antagonists; Enantiomers; Human LDL; Org 13061

Indexed keywords

ANTIOXIDANT; CALCIUM ANTAGONIST; DILTIAZEM; NIFEDIPINE; ORG 13061; ORG 13471; ORG 13581; OXIDIZED LOW DENSITY LIPOPROTEIN; PROBUCOL; UNCLASSIFIED DRUG; VERAPAMIL;

EID: 0030867386     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1997.tb00204.x     Document Type: Article
Times cited : (1)

References (42)
  • 1
    • 0024839881 scopus 로고
    • Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: Probucol degradation precedes lipoprotein oxidation
    • Barnhart RL, Busch SJ, Jackson RL. Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation. J Lipid Res 1989;30:1703-10
    • (1989) J Lipid Res , vol.30 , pp. 1703-1710
    • Barnhart, R.L.1    Busch, S.J.2    Jackson, R.L.3
  • 2
    • 0018749729 scopus 로고
    • Mechanisms of action of transmitters and other substances on smooth muscle
    • Bolton TB. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 1979;59:606-718
    • (1979) Physiol Rev , vol.59 , pp. 606-718
    • Bolton, T.B.1
  • 3
    • 0025999832 scopus 로고
    • Calcium antagonists prevent monocyte and endothelial cell-induced modification of low density lipoproteins
    • Breugnot C, Mazière C, Auclair M, Mora L, Ronveaux MF, Salmon S et al. Calcium antagonists prevent monocyte and endothelial cell-induced modification of low density lipoproteins. Free Rad Res Commun 1991;15:91-100
    • (1991) Free Rad Res Commun , vol.15 , pp. 91-100
    • Breugnot, C.1    Mazière, C.2    Auclair, M.3    Mora, L.4    Ronveaux, M.F.5    Salmon, S.6
  • 5
    • 0029885126 scopus 로고    scopus 로고
    • Endothelial dysfunction in atherosclerosis
    • Busse R, Fleming I. Endothelial dysfunction in atherosclerosis. J Vasc Res 1996;33:181-94
    • (1996) J Vasc Res , vol.33 , pp. 181-194
    • Busse, R.1    Fleming, I.2
  • 6
    • 0007712375 scopus 로고
    • The antiatherogenic potential of calcium antagonists: Experimental evidence
    • Catapano AL. The antiatherogenic potential of calcium antagonists: experimental evidence. J Cardiovasc Pharmacol 1992;20:44-50
    • (1992) J Cardiovasc Pharmacol , vol.20 , pp. 44-50
    • Catapano, A.L.1
  • 7
    • 9844255565 scopus 로고
    • Antiproliferative and intracellular lipid lowering effect of some antioxidants in vitro
    • Chevalier A, Shrivastava R, Beaughard M. Antiproliferative and intracellular lipid lowering effect of some antioxidants in vitro. Fundam Clin Pharmacol 1993;7:7
    • (1993) Fundam Clin Pharmacol , vol.7 , pp. 7
    • Chevalier, A.1    Shrivastava, R.2    Beaughard, M.3
  • 8
    • 0026553493 scopus 로고
    • The pathogenesis of atheroma and the rationale for its treatment
    • Collins P, Fox K. The pathogenesis of atheroma and the rationale for its treatment. Eur Heart J 1992;13:560-5
    • (1992) Eur Heart J , vol.13 , pp. 560-565
    • Collins, P.1    Fox, K.2
  • 9
    • 0028923856 scopus 로고
    • Lipoprotein oxidation as a mediator of atherogenesis: Insights from pharmacological studies
    • Daugherty A, Roselaar SE. Lipoprotein oxidation as a mediator of atherogenesis: insights from pharmacological studies. Cardiovasc Res 1995;29:297-311
    • (1995) Cardiovasc Res , vol.29 , pp. 297-311
    • Daugherty, A.1    Roselaar, S.E.2
  • 10
    • 0016384242 scopus 로고
    • 2+ release during drug induced activation of the rabbit aorta
    • 2+ release during drug induced activation of the rabbit aorta. Pflugers Arch 1974;348:13-22
    • (1974) Pflugers Arch , vol.348 , pp. 13-22
    • Deth, R.1    Van Breemen, C.2
  • 12
    • 0026576932 scopus 로고
    • Vitamin C intake and mortality among a sample of the United States population
    • Engstrom JE, Kanin LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992;3:194-202
    • (1992) Epidemiology , vol.3 , pp. 194-202
    • Engstrom, J.E.1    Kanin, L.E.2    Klein, M.A.3
  • 13
    • 0026657363 scopus 로고
    • The role of lipid peroxidation and antioxidants in oxidative modification of LDL
    • Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad Biol Med 1992;13:341-90
    • (1992) Free Rad Biol Med , vol.13 , pp. 341-390
    • Esterbauer, H.1    Gebicki, J.2    Puhl, H.3    Jurgens, G.4
  • 15
    • 0021811434 scopus 로고
    • Nifedipine increases cholesteryl ester hydrolytic activity in lipid-laden rabbit arterial smooth muscle cells a possible mechanism for its antiatherogenic effect
    • Etingin OR, Hajjar DP. Nifedipine increases cholesteryl ester hydrolytic activity in lipid-laden rabbit arterial smooth muscle cells a possible mechanism for its antiatherogenic effect. J Clin Invest 1985;75:1554-8
    • (1985) J Clin Invest , vol.75 , pp. 1554-1558
    • Etingin, O.R.1    Hajjar, D.P.2
  • 16
    • 0025124613 scopus 로고
    • Calcium channel blockers enhance cholesteryl ester hydrolysis and decrease total cholesterol accumulation in human aortic tissue
    • Etingin OR, Hajjar DP. Calcium channel blockers enhance cholesteryl ester hydrolysis and decrease total cholesterol accumulation in human aortic tissue. Circ Res 1990;66:185-90
    • (1990) Circ Res , vol.66 , pp. 185-190
    • Etingin, O.R.1    Hajjar, D.P.2
  • 17
    • 33745026603 scopus 로고
    • The distribution and chemical composition of ultracentifugally separated lipoproteins in human serum
    • Havel RJ, Eder EH, Bragdon JM. The distribution and chemical composition of ultracentifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-63
    • (1955) J Clin Invest , vol.34 , pp. 1345-1363
    • Havel, R.J.1    Eder, E.H.2    Bragdon, J.M.3
  • 18
    • 0023706741 scopus 로고
    • Calcium antagonists as antiatherogenic agents
    • Henry PD. Calcium antagonists as antiatherogenic agents. Ann NY Acad Sci 1988;522:411-9
    • (1988) Ann NY Acad Sci , vol.522 , pp. 411-419
    • Henry, P.D.1
  • 19
    • 0019837893 scopus 로고
    • Suppression of atherosclerosis in cholesterol-fed rabbit treated with nifedipine
    • Henry PD, Bentley KI. Suppression of atherosclerosis in cholesterol-fed rabbit treated with nifedipine. J Clin Invest 1981;68:1366-9
    • (1981) J Clin Invest , vol.68 , pp. 1366-1369
    • Henry, P.D.1    Bentley, K.I.2
  • 20
    • 0029056560 scopus 로고
    • Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and Superoxide generation
    • Keaney JF, Xu AM, Cunningham D, Jackson T, Frei B, Vita JA. Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and Superoxide generation. J Clin Invest 1995;95:2520-9
    • (1995) J Clin Invest , vol.95 , pp. 2520-2529
    • Keaney, J.F.1    Xu, A.M.2    Cunningham, D.3    Jackson, T.4    Frei, B.5    Vita, J.A.6
  • 21
    • 0024554416 scopus 로고
    • Calcium antagonists and experimental atherosclerosis
    • Kjeldsen K, Stender S. Calcium antagonists and experimental atherosclerosis. Proc Soc Exp Biol Med 1989;190:219-28
    • (1989) Proc Soc Exp Biol Med , vol.190 , pp. 219-228
    • Kjeldsen, K.1    Stender, S.2
  • 23
    • 0028114273 scopus 로고
    • In vitro antioxidant activity of calcium antagonists against LDL oxidation compared with α-tocopherol
    • Lupo E, Locher R, Weisser B, Vetter W. In vitro antioxidant activity of calcium antagonists against LDL oxidation compared with α-tocopherol. Biochem Biophys Res Commun 1994;203:1803-8
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 1803-1808
    • Lupo, E.1    Locher, R.2    Weisser, B.3    Vetter, W.4
  • 24
    • 0027381095 scopus 로고
    • The antioxidant vitamins: Impact on atherosclerosis
    • Meyers DJ, Maloley PA. The antioxidant vitamins: impact on atherosclerosis. Pharmacotherapy 1993;13:574-82
    • (1993) Pharmacotherapy , vol.13 , pp. 574-582
    • Meyers, D.J.1    Maloley, P.A.2
  • 25
    • 0026615755 scopus 로고
    • 2+ channel blockers (nifedipine, diltiazem and verapamil) against the toxicity of oxidized low density lipoprotein to cultured lymphoid cells
    • 2+ channel blockers (nifedipine, diltiazem and verapamil) against the toxicity of oxidized low density lipoprotein to cultured lymphoid cells. Br J Pharmacol 1992;107:738-44
    • (1992) Br J Pharmacol , vol.107 , pp. 738-744
    • Nègre-Salvayre, A.1    Salvayre, R.2
  • 26
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 27
    • 0025572219 scopus 로고
    • In vitro models of antiatherosclerotic effects of cardiovascular drugs
    • Orekhov AN. In vitro models of antiatherosclerotic effects of cardiovascular drugs. Am J Cardiol 1990;66:23-8
    • (1990) Am J Cardiol , vol.66 , pp. 23-28
    • Orekhov, A.N.1
  • 28
    • 0025973978 scopus 로고
    • Use of human atherosclerotic cells for optimization of antiatherosclerotic therapy
    • Orekhov AN. Use of human atherosclerotic cells for optimization of antiatherosclerotic therapy. Agents Actions 1991; 32:130-1
    • (1991) Agents Actions , vol.32 , pp. 130-131
    • Orekhov, A.N.1
  • 29
    • 0022591979 scopus 로고
    • The pathogenesis of atherosclerosis - An update
    • Ross R. The pathogenesis of atherosclerosis - an update. N Engl J Med 1986;314:488-500
    • (1986) N Engl J Med , vol.314 , pp. 488-500
    • Ross, R.1
  • 30
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-9
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 31
    • 0028117840 scopus 로고
    • Dipyridamole inhibits the oxidative modification of low density lipoprotein
    • Selley ML, Czeti AL, McGuiness JA, Ardlie NG. Dipyridamole inhibits the oxidative modification of low density lipoprotein. Atherosclerosis 1994;111:91-7
    • (1994) Atherosclerosis , vol.111 , pp. 91-97
    • Selley, M.L.1    Czeti, A.L.2    McGuiness, J.A.3    Ardlie, N.G.4
  • 32
    • 0027379970 scopus 로고
    • An in vitro method using vascular smooth muscle cells to study the effect of compounds on cell proliferation and intracellular lipid accumulation
    • Shrivastava R, Chevalier A, Slaoui M, John G. An in vitro method using vascular smooth muscle cells to study the effect of compounds on cell proliferation and intracellular lipid accumulation. Methods Find Exp Clin Pharmacol 1993;15:345-50
    • (1993) Methods Find Exp Clin Pharmacol , vol.15 , pp. 345-350
    • Shrivastava, R.1    Chevalier, A.2    Slaoui, M.3    John, G.4
  • 33
    • 0026708232 scopus 로고
    • Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N′-diphenylphenylenediamine
    • Sparrow CP, Doebber TW, Olszewski J, Wu MS, Ventre J, Stevens KA et al. Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N′-diphenylphenylenediamine. J Clin Invest 1992;89:1885-91
    • (1992) J Clin Invest , vol.89 , pp. 1885-1891
    • Sparrow, C.P.1    Doebber, T.W.2    Olszewski, J.3    Wu, M.S.4    Ventre, J.5    Stevens, K.A.6
  • 35
    • 0023500819 scopus 로고
    • Long-term effects of verapamil on aortic smooth muscle cells cultured in the presence of hypercholesterolemic serum
    • Stein O, Halperin G, Stein Y. Long-term effects of verapamil on aortic smooth muscle cells cultured in the presence of hypercholesterolemic serum. Arteriosclerosis 1987;7:585-92
    • (1987) Arteriosclerosis , vol.7 , pp. 585-592
    • Stein, O.1    Halperin, G.2    Stein, Y.3
  • 36
    • 0024603895 scopus 로고
    • Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
    • Steinberg D, Parthasarathy S, Casew TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-24
    • (1989) N Engl J Med , vol.320 , pp. 915-924
    • Steinberg, D.1    Parthasarathy, S.2    Casew, T.E.3    Khoo, J.C.4    Witztum, J.L.5
  • 37
  • 38
    • 0028289762 scopus 로고
    • Increase in intracellular calcium ion in smooth muscle cells induced by low-density lipoprotein
    • Tasaki H, Yamashita K, Nakashima Y, Kuroiwa A, Tulenko TN. Increase in intracellular calcium ion in smooth muscle cells induced by low-density lipoprotein. Gerontology 1994;40:23-8
    • (1994) Gerontology , vol.40 , pp. 23-28
    • Tasaki, H.1    Yamashita, K.2    Nakashima, Y.3    Kuroiwa, A.4    Tulenko, T.N.5
  • 39
    • 0025615223 scopus 로고
    • A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis
    • Waters D, Lesperance J, Franchetich M, Causey D, Theroux P, Chiang YK et al. A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis. Circulation 1990;82:1940-53
    • (1990) Circulation , vol.82 , pp. 1940-1953
    • Waters, D.1    Lesperance, J.2    Franchetich, M.3    Causey, D.4    Theroux, P.5    Chiang, Y.K.6
  • 40
    • 0010237397 scopus 로고
    • Calcium and contractility in smooth muscle
    • Weiss GB. Calcium and contractility in smooth muscle. Adv Gen Cell Pharmacol 1977;2:71-154
    • (1977) Adv Gen Cell Pharmacol , vol.2 , pp. 71-154
    • Weiss, G.B.1
  • 41
    • 0023005863 scopus 로고
    • The effects of bepridil compared with calcium antagonists on rat and rabbit aorta
    • Winslow E, Farmer S, Martorana M, Marshall RJ. The effects of bepridil compared with calcium antagonists on rat and rabbit aorta. Eur J Pharmacol 1986;131:219-28
    • (1986) Eur J Pharmacol , vol.131 , pp. 219-228
    • Winslow, E.1    Farmer, S.2    Martorana, M.3    Marshall, R.J.4
  • 42
    • 0027507082 scopus 로고
    • Role of oxidised low density lipoprotein in atherogenesis
    • Witztum JL. Role of oxidised low density lipoprotein in atherogenesis. Br Heart J 1993;69:12-8
    • (1993) Br Heart J , vol.69 , pp. 12-18
    • Witztum, J.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.